The effects of nitric oxide on the acquisition and expression of nicotine-induced conditioned place preference in mice

Sahraei, Hedayat; Falahi, M J; Zarrindast, M.R.; Sabetkasaei, Masoomeh; Ghoshooni, Hassan; Khalili, Mohsen

doi:10.1016/j.ejphar.2004.08.054

Cited by 28 publications

(28 citation statements)

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“…In recent years, studies using conditioned place preference suggested interactions between the nicotinic and NO systems in mice [11] . However, no studies have shown that the NOergic neuronal system affects the cholinergic system or nAChRs and its effects on learning and memory.…”

Section: Discussionmentioning

confidence: 99%

“…Under pathological conditions, increased α7 nAChRs also contribute to the enhancement of NO formation in astrocytes in the human hippocampus and entorhinal cortex [10] . A recent study using conditioned place preference revealed interactions between the nicotinic and NO systems [11] . For instance, inhibition of NOS by 7-nitroindazole inhibits the development of place preference [12] and behavioral sensitization induced by nicotine in the rat [13] .…”

Section: Introductionmentioning

confidence: 99%

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Effects of L-arginine and Nω-nitro-L-arginine methylester on learning and memory and α7 nAChR expression in the prefrontal cortex and hippocampus of rats

et al. 2013

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Nitric oxide (NO) is a novel type of neurotransmitter that is closely associated with synaptic plasticity, learning and memory. In the present study, we assessed the effects of L-arginine and N ω -nitro-Larginine methylester (L-NAME, a nitric oxide synthase inhibitor) on learning and memory. Rats were assigned to three groups receiving intracerebroventricular injections of L-Arg (the NO precursor), L-NAME, or 0.9% NaCl (control), once daily for seven consecutive days. Twelve hours after the last injection, they underwent an electric shock-paired Y maze test. Twenty-four hours later, the rats' memory of the safe illuminated arm was tested. After that, the levels of NO and α7 nicotinic acetylcholine receptor (α7 nAChR) in the prefrontal cortex and hippocampus were assessed using an NO assay kit, and immunohistochemistry and Western blots, respectively. We found that, compared to controls, L-Arg-treated rats received fewer foot shocks and made fewer errors to reach the learning criterion, and made fewer errors during the memory-testing session. In contrast, L-NAME-treated rats received more foot shocks and made more errors than controls to reach the learning criterion, and made more errors during the memory-testing session. In parallel, NO content in the prefrontal cortex and hippocampus was higher in L-Arg-treated rats and lower in L-NAME rats, compared to controls. Similarly, α7 nAChR immunoreactivity and protein expression in the prefrontal cortex and hippocampus were higher in L-Arg-treated rats and lower in L-NAME rats, compared to controls. These results suggest that the modulation of NO content in the brain correlates with α7 nAChR distribution and expression in the prefrontal cortex and hippocampus, as well as with learning and memory performance in the Y-maze.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of L-arginine and Nω-nitro-L-arginine methylester on learning and memory and α7 nAChR expression in the prefrontal cortex and hippocampus of rats

et al. 2013

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“…Studies examining nicotine-conditioned place preference in mice have been performed almost exclusively in males ( Agatsuma et al, 2006 ;Balerio, Aso, & Maldonado, 2005 ;Grabus, Martin, Brown, & Damaj, 2006 ;McGeehan & Olive, 2003 ;Nolley & Kelley, 2007 ;Rauhut, Hawrylak, & Mardekian, 2008 ;Sahraei et al, 2004 ) or in both males and females Walters, Brown, Changeux, Martin, & Damaj, 2006 ;Walters, Cleck, Kuo, & Blendy, 2005 ). Males and females of the ICR mouse strain have been characterized extensively but in separate studies ( Grabus et al, 2006 ;Kota, Martin, & Damaj, 2008 ;Kota, Martin, Robinson, & Damaj, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

Sex differences in response to nicotine in C57Bl/6:129SvEv mice

Isiegas

Mague²,

Blendy³

2009

Nicotine &Amp; Tobacco Research

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Results:Females responded more to the conditioned rewarding effects of nicotine compared with males. Males, however, seemed more responsive to the pharmacological aspects of nicotine by reducing nicotine drinking at higher concentrations; females maintained consistent levels of intake over several doses of nicotine. Male and female mice demonstrated similar locomotor and antinociceptive responses to nicotine. Discussion: These data suggest that place-conditioning and two-bottle choice paradigms may be more sensitive measures of sexual dimorphism in the C57BL/6:129SvEv hybrid mouse than are locomotor or nociception assays.

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“…Cumulating evidence has supported the hypothesis that some behavioral effects of nicotine and ethanol are mediated by NO (6,23,25). For instance, the inhibition of NOS has been reported to attenuate various nicotine-induced addictive behaviors including the dependence (26), sensitization (22), withdrawal (27) and reward (28).…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, there exist some welldemonstrated interactions between nicotine and NO (22)(23)(24). Cumulating evidence has supported the hypothesis that some behavioral effects of nicotine and ethanol are mediated by NO (6,23,25).…”

Section: Introductionmentioning

confidence: 99%

Activation of the Nitric-Oxide System in Nucleus Accumbens Inhibits the Nicotine Reversal Effects upon Ethanol-Induced Amnesia

Raoufi¹,

Moshfegh²,

Piri³

et al. 2016

Journal of Advanced Medical Sciences and Applied Technologies

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The present study investigated the possible involvement of the nucleus accumbens' (NAc) nitric oxide system in nicotine's reversal effect upon ethanol-induced amnesia. The hypothesis was tested through ethanol state-dependent memory assessment in adult male Wistar rats. Bilateral chronic cannulae were implanted in the NAc and the animals were trained in a step-through type inhibitory avoidance memory task. The step-through latency was examined 24 h after animals' training. The pre-training or pre-test intraperitoneal (i.p.) injection of ethanol (0.9 g/kg) decreased the step-through latency, indicating an amnesic effect of the drug. Meanwhile, the pre-test administration of ethanol (0.6 and 0.9 g/kg) could reverse the pre-training ethanol (0.9 g/kg)-induced amnesia, suggesting a state-dependent effect. Similar to ethanol, the pre-test intra-NAc microinjection of nicotine (0.25 and 0.5 µg/rat) alone or nicotine (0.1, 0.25 and 0.5 µg/mouse, intra-NAc) in combination with an ineffective dose of ethanol (0.3 g/kg) could significantly reverse the (pre-training) ethanol-induced memory impairment. The ethanol (0.9 g/kg)-induced amnesia was similarly prevented following the pre-test intra-NAc administration of a nitric oxide synthase (NOS) inhibitor, L-NAME (0.4 and 0.8 µg/rat). Of note, the co-administration of L-NAME (0.04 and 0.08 µg/rat, intra-NAc) with an ineffective dose of nicotine (0.1 µg/rat, intra-NAc) could significantly potentiate the memoryimproving effect of nicotine on ethanol-induced amnesia and resembled the effects of pretest administration of a higher dose of nicotine. Furthermore, while the pre-test intra-NAc injection of L-NAME impaired the memory retrieval by itself, the pre-test intra-NAc administration of L-arginine, a nitric oxide precursor (0.3 and 0.6 µg/rat, intra-NAc), did not exert any effect either alone or in combination with an effective dose of nicotine (0.5 µg/rat, intra-NAc) on pre-training ethanol-induced memory impairment. Our findings indicated a possible role of the nucleus accumbens' nitric oxide system in the improving effects of nicotine on ethanol-induced amnesia and the related state-dependent learning.

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The effects of nitric oxide on the acquisition and expression of nicotine-induced conditioned place preference in mice

Cited by 28 publications

References 28 publications

Effects of L-arginine and Nω-nitro-L-arginine methylester on learning and memory and α7 nAChR expression in the prefrontal cortex and hippocampus of rats

Effects of L-arginine and Nω-nitro-L-arginine methylester on learning and memory and α7 nAChR expression in the prefrontal cortex and hippocampus of rats

Sex differences in response to nicotine in C57Bl/6:129SvEv mice

Activation of the Nitric-Oxide System in Nucleus Accumbens Inhibits the Nicotine Reversal Effects upon Ethanol-Induced Amnesia

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