The Effects of Nitric Oxide Production and Lymphedema Treatment on A Pregnant Female with A History of Recurrent Abortion: A Case Report

Abstract

Article informationBackground: The association between lymphedema and recurrent abortion is not fully clarified. In the present case, I report the occurrence of acute dermatolymphangio-adenitis [previously: cellulitis] about three days before each abortion and the effect of non-surgical treatment of lymphedema on pregnancy.Case presentation: A 30-years old nulliparous pregnant female complains of right lower limb lymphedema with a history of recurrent abortion. Measurement of Lymphedema circumference and serum nitric oxide assay were done before, during, and after treatment. She was treated by intermittent pneumatic compression to produce wall shear stress on blood and lymphatic vessels, chemical compression by a zinc oxide paste bandage, and, a special elastic stocking. There was a statistically significant increase in serum nitric oxide concentration [F-test=75.814, p<0.001] together with a statistically significant decrease in lymphedema circumference [F-test=24.564, p=0.005]. After treatment there were no acute dermatolymphangioadenitis attacks, the lymphedema subsided and she delivered a fullterm healthy infant.Conclusions: This study aimed to report the safety and efficacy of conservative treatment of lymphedema in a pregnant female with a history of recurrent abortion.