The Effects of Nitrous Oxide on Vascular Endothelial Growth Factor (Vegf) and Its Soluble Receptor 1 (Vegfr1) in Patient Undergoing Urological Surgery

Abstract

Objective: Anesthesia and surgical intervention, leads to the development of systemic inflammatory response. The severity of the inflammatory response depends on the pharmacological effects of anesthetic agents and duration of anesthesia. Objective of the study was to investigate the effect of nitrous oxide on VEGF and VEGFR1 levels in patients undergoing surgery. Methods: Forty-four patients undergoing elective urological surgery were included in the study. Anesthesia maintenance was provided with 1-2 MAC sevoflurane, O2 50%, N2O 50% in 4L/m transporter gase for group 1 (n=22) and 1-2 MAC sevoflurane, O2 50%, air 50% in 4L/m transporter gase for group 2 (n=22) Venous blood samples for the measurement of VEGF and VEGFR1 were taken before the induction of anaesthesia, 60 minutes of anesthesia induction, at the end of anaesthesia and 24 hours after operation. In statistical analysis Bonferroni test and analysis of variance at the repeated measures were used Results: In the postoperative period serum VEGF levels had decreased significantly in both group whereas VEGFR1 did not show a significant change. Conclusions: Nitrous oxide showed significant effect on angiogenic parameters. Further detailed studies are required to evaluate the effect of nitrous oxide.

Zinc Finger Protein-Activating Transcription Factor stimulates the angiogenesis and maturity of the neovessels in the Mouse With Hindlimb ischemia and Rat mesenteric Assay

“…The main reason lies in the endogenous therapeutic angiogenesis is a complex physiological process [10]. Moreover, VEGF gene expression in vivo began at 4H after the appearance of the severe ischemia, peaked at 3-5 days, but gradually decreased on the 7th day [11,12]. Therefore, the endogenous restricted expression of VEGF can not satisfy with the concentration required for neovascularization in ischemic limb.…”

A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies

“…As for vascular growth factors, one potential target is Vascular Endothelial Growth Factor (VEGF). Clinical studies have shown that VEGF expression levels decrease after exposure to nitrous oxide during urological surgery (Hakimoglu et al, 2014). Therefore, future studies investigating changes in vascular plasticity during early developmental exposure to anesthesia are needed.…”