2013
DOI: 10.1016/j.joca.2013.06.026
|View full text |Cite
|
Sign up to set email alerts
|

The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial

Abstract: Short-term NSAID treatment improves the patient disease-specific quality of life with a parallel decrease in pro-inflammatory synovial fluid cytokine levels in knee OA. Signal transduction pathways may be involved in regulating the anti-inflammatory effects of NSAIDs. ClinicalTrial.gov: NCT01860833.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

4
101
0
2

Year Published

2014
2014
2024
2024

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 120 publications
(107 citation statements)
references
References 50 publications
4
101
0
2
Order By: Relevance
“…Inhibition of mitogen-activated protein kinases (MAPKs) was noted after non-steroidal anti-inflammatory drug treatment. 70 Thus, such promising drugs can be used in forms of nanotherapy. These nanosystems have the capability to release the drug slowly in the environment; therefore, lower and reduced drug dosages are required hence avoiding the non-specific side effects of the drugs.…”
Section: Np Therapy In Arthritismentioning
confidence: 99%
“…Inhibition of mitogen-activated protein kinases (MAPKs) was noted after non-steroidal anti-inflammatory drug treatment. 70 Thus, such promising drugs can be used in forms of nanotherapy. These nanosystems have the capability to release the drug slowly in the environment; therefore, lower and reduced drug dosages are required hence avoiding the non-specific side effects of the drugs.…”
Section: Np Therapy In Arthritismentioning
confidence: 99%
“…Similarly, musculo-skeletal trauma, as during surgery, causes an inflammatory response that leads, at first, to an elevation of the pro-inflammatory cytokines in the plasma and later, the anti-inflammatory cytokines step in so that a balanced inflammatory response is seen perioperatively. Osteoarthritis of the hip joint results in an increase in pro-inflammatory mediators, specifically IL-6, IL-8 and TNF-α in the synovial fluid [8]. NSAIDs commonly used for the treatment of osteoarthritis decrease IL-6, TNF-alpha and VEGF in the synovial fluid with an improvement in joint pain and function [8].…”
Section: Discussionmentioning
confidence: 99%
“…nonselective nonsteroidal anti-inflammatory drugs (NSAIDs). 85 Although these pharmacological agents have been reported to provide analgesia and reduce inflammation following shortterm treatment, 86 long-term use is associated with adverse side effects, including gastrointestinal toxicity and increased risk of cardiovascular events. 87 89 and certain NSAIDs have been found to negatively impact collagen metabolism and GAG synthesis.…”
Section: Infiltrating Cd3mentioning
confidence: 99%