The effects of noradrenergic re-uptake inhibition on memory encoding in man

Papps, Benjamin; Shajahan, Polash; Ebmeier, Klaus P.; O’Carroll, Ronan E.

doi:10.1007/s00213-001-0924-y

Cited by 24 publications

(19 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Data with healthy subjects, however, are not consistent, with some studies failing to observe enhanced memory consolidation for emotional material after selectively manipulating the noradrenergic system (Papps et al, 2002). Of particular interest with respect to the opposing effects on memory performance with different noradrenergic substances (yohimbine vs reboxetine) is the fact that both substances increased heart rate compared to placebo (cf Papps et al, 2002). This supports our conclusion that AMPH's effects on memory consolidation are independent of its arousal effects.…”

Section: D-amphetamine Boosts Language Learning C Breitenstein Et Almentioning

confidence: 72%

“…Studies with healthy subjects generally suggest that noradrenergic actions mediate the influence of emotional arousal on memory consolidation (eg Southwick et al, 2002), presumably through its action on the amygdala (McIntyre et al, 2003). Data with healthy subjects, however, are not consistent, with some studies failing to observe enhanced memory consolidation for emotional material after selectively manipulating the noradrenergic system (Papps et al, 2002). Of particular interest with respect to the opposing effects on memory performance with different noradrenergic substances (yohimbine vs reboxetine) is the fact that both substances increased heart rate compared to placebo (cf Papps et al, 2002).…”

Section: D-amphetamine Boosts Language Learning C Breitenstein Et Almentioning

confidence: 99%

See 1 more Smart Citation

D-Amphetamine Boosts Language Learning Independent of its Cardiovascular and Motor Arousing Effects

Breitenstein

Wailke

Bushuven

et al. 2004

Neuropsychopharmacol

View full text Add to dashboard Cite

D-Amphetamine (AMPH) was effective in a number of studies on motor and language recovery after stroke, but given safety concerns, its general use after stroke is still debated. Most stroke patients are excluded from treatment because of a significant risk of cardiovascular dysregulation. AMPH acts on multiple transmitter systems, and mainly the noradrenergic actions are related to the cardiovascular effects. If AMPH's cardiovascular and arousal effects were correlated with its plasticity-enhancing effects in humans, this would imply that desired and undesired effects are inevitably tied. If not, improved cerebral reorganization may not be mediated by AMPH's arousing effects and could be achieved with substances lacking the undesired cardiovascular effects. As a model for language recovery after stroke, we used a prospective, randomized, double-blind, placebo-controlled design and taught 40 healthy male subjects an artificial vocabulary of 50 concrete nouns over the course of five consecutive training days (high-frequency training). The associative learning principle involved higher co-occurrences of 'correct' picturepseudoword pairings as compared to 'incorrect' pairings. Subjects received either AMPH (0.25 mg/kg) or placebo 90 min prior to training on each day. Novel word learning was significantly faster and better in the AMPH as compared to the placebo group. Increased learning success was maintained 1 month post-training. No correlation was found between training success and drug-induced increases in blood pressure, heart rate, or a facilitation of simple motor reaction time. Our data show that AMPH's plasticity-enhancing effect in humans is not related to its cardiovascular arousal. This suggests that the beneficial effects in stroke patients could also be obtained by less cardiovascular active drugs.

show abstract

Section: D-amphetamine Boosts Language Learning C Breitenstein Et Almentioning

confidence: 72%

Section: D-amphetamine Boosts Language Learning C Breitenstein Et Almentioning

confidence: 99%

D-Amphetamine Boosts Language Learning Independent of its Cardiovascular and Motor Arousing Effects

Breitenstein

Wailke

Bushuven

et al. 2004

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Whereas yohimbine-elicited NE potentiation amplified consolidation and free recall of emotional events (O'Carroll et al, 1999a;Southwick et al, 2002), no effect of prelearning single-dose administrations of 4 and 8 mg reboxetine on emotional recall tested after a 7 d retention interval has also been reported (Papps et al, 2002). In contrast, Harmer et al (2003) found that a 4 mg single dose of reboxetine administered 2 h before testing enhanced free recall of positive rather than negative stimuli in the absence of changes in nonemotional performance or mood.…”

Section: Discussionmentioning

confidence: 98%

“…The source of central NE is the locus ceruleus (LC), which responds to novelty (Sara et al, 1994) and emotional arousal (Berridge and Waterhouse, 2003). Pharmacological manipulations that enhance a central NE response to emotional arousal (e.g., by application of reboxetine) (Harmer et al, 2003(Harmer et al, , 2004 (but see Papps et al, 2002) or the ␣2 adrenergic antagonist yohimbine (O'Carroll et al, 1999a;Southwick et al, 2002), have been shown to facilitate episodic memory formation (but see Murchison et al, 2004). In contrast, propranolol selectively compromises the memory benefit for emotionally arousing events (Cahill et al, 1994;Strange et al, 2003;van Stegeren et al, 2005) (but see O'Carroll et al, 1999b) in a manner similar to amygdala damage (Cahill et al, 1995;Strange et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Noradrenergic Modulation of Emotion-Induced Forgetting and Remembering

Hurlemann¹,

Hawellek²,

Matusch³

et al. 2005

J. Neurosci.

147

207

View full text Add to dashboard Cite

We used a free-recall paradigm to establish a behavioral index of the retrograde and anterograde interference of emotion with episodic memory encoding. In two experiments involving 78 subjects, we show that negatively valenced items elicit retrograde amnesia, whereas positively valenced items elicit retrograde hypermnesia. These data indicate item valence is critical in determining retrograde amnesia and retrograde hypermnesia. In contrast, we show that item arousal induces an anterograde amnesic effect, consistent with the idea that a valence-evoked arousal mechanism compromises anterograde episodic encoding. Randomized double-blind administration of the ␤-adrenoceptor antagonist propranolol compared with the selective norepinephrine (NE) reuptake-inhibitor reboxetine, and placebo, demonstrated that the magnitude of this emotional amnesia and hypermnesia can be upregulated and downregulated as a function of emotional arousal and central NE signaling. We conclude that a differential processing of emotional arousal and valence influences how the brain remembers and forgets.

show abstract

“…Contrary to expectations, reboxetine (8 mg single dose) did not improve attention, memory or learning in healthy adults [79][80][81]. It has been suggested that a single dose is not sufficient for significant effectiveness on cognitive performances.…”

Section: Selective Norepinephrin Reuptake Inhibitorsmentioning

confidence: 87%

Neuroenhancement in Healthy Adults, Part I: Pharmaceutical Cognitive Enhancement: A Systematic Review

Micoulaud¹

2015

J Clinic Res Bioeth

View full text Add to dashboard Cite

The term neuroenhancement refers to improvement in the cognitive, emotional and motivational functions of healthy individuals through inter alia, the use of drugs. This popular topic attracts attention both from the general public and the scientific community. Our objective is to summarize in a synthetic review the data of randomized placebo-controlled trials that assessed cognitive effects of administration of neuroenhancers in non-sleep-deprived healthy adults compared to placebo. The major outcomes were attention, memory, learning, executive functions, and vigilance/wakefulness. Details on the pharmacological profile, effectiveness and safety for each drug are provided. We classify them according to their recognized major primary mode of action, namely catecholaminergics (methylphenidate,

show abstract

The effects of noradrenergic re-uptake inhibition on memory encoding in man

Abstract: Selective stimulation of the central noradrenergic system at encoding did not result in enhanced long-term memory for emotional material in man.

Cited by 24 publications

References 24 publications

D-Amphetamine Boosts Language Learning Independent of its Cardiovascular and Motor Arousing Effects

D-Amphetamine Boosts Language Learning Independent of its Cardiovascular and Motor Arousing Effects

Noradrenergic Modulation of Emotion-Induced Forgetting and Remembering

Neuroenhancement in Healthy Adults, Part I: Pharmaceutical Cognitive Enhancement: A Systematic Review

Contact Info

Product

Resources

About