The Effects of Normobaric Hyperoxia Pre- and Post-treatment on the Development of Noise-Induced Hearing Loss in Rats

Faridan, Mohammad; Khavanin, Ali; Mirzaei, Ramazan; Salehnia, M

doi:10.5812/jhealthscope.63169

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…Chambers for simultaneous exposure to noise and toluene were designed according to the suggestions of previous studies [19][20][21]. The dimensions and the material used in the construction of chambers was according to the rats' needs.…”

Section: Exposure Chamber Speci Cationsmentioning

confidence: 99%

An investigation of oxidative stress parameters and histopathological changes due to simultaneous exposure to toluene and loud noise in brain tissue of adult male rats

Beyrami

niri

Panahi

et al. 2023

Preprint

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Background: Occupational and environmental exposures to organic solvents and noises in the workplace are major health issues. One of these solvents is toluene, and on top of that noise is an impartible part of any industry. the present study aims to determine the alteration of oxidative stress parameters and the histopathological changes caused by simultaneous exposure to toluene and noise in the brain tissue. Methods: For this purpose, 32 male Wistar rats were divided into four experimental groups and then were exposed to varying factors for 8 hours a day (8 h/day) for 28 days. These four groups were: 1) The control group, 2) The group exposed to noise (100dB), 3) The group exposed to toluene by inhalation (500 ppm), and 4) The group simultaneously exposed to both of them. In this study, the levels of lipid peroxidation (MDA) and glutathione (GSH) and the histopathological changes of the brain tissue were determined. Results:The findings suggest that, in the various parts of the temporal brain tissue simultaneously exposed to toluene and noise, the cohesion was more decreased compared to the tissues in other groups. Furthermore, in the group simultaneously exposed to both factors the MDA level increased and the GSH level decreased significantly. Conclusions: The results indicated the impact of synergistic interaction between noise and toluene on the accumulation of oxidation products, the progressive morphological damages as well as the weakening of the antioxidant defense system in brain tissues of rats and being simultaneously exposed to both factors has a cumulative effect

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Section: Exposure Chamber Speci Cationsmentioning

confidence: 99%

An investigation of oxidative stress parameters and histopathological changes due to simultaneous exposure to toluene and loud noise in brain tissue of adult male rats

Beyrami

niri

Panahi

et al. 2023

Preprint

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“…In this study, we investigated the effect of noise (80 -120 dB) (15,22) and styrene (50 to 1000 ppm) (23, 24) on the working memory and locomotor activity. In another part of the study, we examined the effect of simultaneous exposure to noise (100 dB) and styrene (750 ppm concentration) on working memory and locomotor activity in male rats.…”

Section: Experimental Protocolmentioning

confidence: 99%

The Effects of Simultaneous Exposure to Styrene and Noise on Working Memory, Anxiety and Locomotor Activity in Rats

et al. 2019

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Background: In addition to a variety of organic solvents, workers in many industries are also exposed to excessive noise levels. Objectives: The purpose of this study was to evaluate the co-exposure effects of bandpass noise and styrene on working memory, anxiety, and locomotor activity in rats. Methods: Thirty male Wistar albino rats were used. Animals were divided into 4 groups, including the noise exposure group (1), styrene exposure group (750 ppm), simultaneous subacute exposure to noise and styrene group (100 dB, 750 ppm), and the control group. The exposure duration was 6 hours/day, 6 days/week in 3 consecutive weeks. At the end of the exposure, the locomotor activity and working memory were evaluated using open field test and Y-maze test, respectively. Results: The results showed that simultaneous exposure to noise and styrene significantly decreased locomotor activity compared to the control group (P < 0.0001), whereas noise and styrene alone had no significant effect on locomotor activity. Spontaneous alternation in the simultaneous exposure group showed no significant difference compared with the noise and styrene groups. Also, simultaneous exposure to styrene and noise significantly decreased working memory compared to the control group (P < 0.0001). Conclusions: Co-exposure to noise and styrene have significant destructive effects on the brain and behaviors and these harmful effects should be considered in the workplace. However, further human and molecular studies should be conducted to clarify its accurate effects and mechanisms.

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“… 5 6 Meanwhile, pre-treatment of the rats with normobaric hyperoxia have contributed to a significant reduction in ABR threshold shifts, and improving the distortion-product otoacoustic emissions amplitudes. 7 …”

Section: Introductionmentioning

confidence: 99%

The impact of carbon monoxide inhalation on developing noise-induced hearing loss in guinea pigs

et al. 2020

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Carbon monoxide (CO) poisoning is one of the most common types of fatal poisonings worldwide. Acute exposure to high levels of CO as well as chronic exposure to low levels of CO and excessive noise can lead to high frequency hearing loss. In this study, twelve guinea pigs were randomly divided into two groups: (1) exposed to noise and (2) exposed to noise plus CO. Auditory brainstem responses (ABRs) were measured prior to the experiment and immediately, 5, 10 and 15 days post exposures. There was a significant difference between the ABR thresholds before and immediately after exposure to noise at frequencies of 4, 8, and 16 kHz and the most threshold shift was observed at 8 kHz. There was also a significant difference between the ABR thresholds before and immediately after exposure to noise and CO at frequencies of 2, 4, 8, and 16 kHz which demonstrated a temporary hearing loss after exposure to noise and CO and the major impact of CO on developing noise induced hearing loss occurred at 8 kHz. No significant difference was observed between the ABR thresholds recorded before conducting the experiments and the ones obtained 5, 10 and 15 days after simultaneous exposure to noise and CO at none of frequencies. Simultaneous exposure to noise and CO contributes to transient hearing loss in guinea pigs with the most evident temporary shift at 8 kHz. The methods were accepted in the Ethics Committee of Iran University of Medical Science (registration No. CTRI/2016/01/017170) on January 18, 2016.

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The Effects of Normobaric Hyperoxia Pre- and Post-treatment on the Development of Noise-Induced Hearing Loss in Rats

Cited by 9 publications

References 24 publications

An investigation of oxidative stress parameters and histopathological changes due to simultaneous exposure to toluene and loud noise in brain tissue of adult male rats

An investigation of oxidative stress parameters and histopathological changes due to simultaneous exposure to toluene and loud noise in brain tissue of adult male rats

The Effects of Simultaneous Exposure to Styrene and Noise on Working Memory, Anxiety and Locomotor Activity in Rats

The impact of carbon monoxide inhalation on developing noise-induced hearing loss in guinea pigs

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