2009
DOI: 10.4046/trd.2009.67.2.95
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The Effects of Nuclear Factor-κB Decoy Oligodeoxynucleotide on Lipopolysaccharide-Induced Direct Acute Lung Injury

Abstract: Background: The pathophysiologic mechanisms of early acute lung injury (ALI) differ according to the type of primary insult. It is important to differentiate between direct and indirect pathophysiologic pathways, and this may influence the approach to treatment strategies. NF-κB decoy oligodeoxynucleotide (ODN) is a useful tool for the blockade of the expression of NF-κB-dependent proinflammatory mediators and has been reported to be effective in indirect ALI. The purpose of this study was to investigate the e… Show more

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Cited by 2 publications
(1 citation statement)
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“…It is also thought to be the primary link between ongoing infections, persistent inflammation, and a higher probability of acquiring cancer [51]. Kim et al [52] conducted an in vivo study using mice as their test subjects. The study aimed at looking how early acute lung injuries (ALI) that have been caused by lipopolysaccharide (LPS) would be affected by the intratracheal administration of NFκB Decoy ODN.…”
Section: Nfκb Inhibiting Decoy Odns Used For the Treatment Of Respira...mentioning
confidence: 99%
“…It is also thought to be the primary link between ongoing infections, persistent inflammation, and a higher probability of acquiring cancer [51]. Kim et al [52] conducted an in vivo study using mice as their test subjects. The study aimed at looking how early acute lung injuries (ALI) that have been caused by lipopolysaccharide (LPS) would be affected by the intratracheal administration of NFκB Decoy ODN.…”
Section: Nfκb Inhibiting Decoy Odns Used For the Treatment Of Respira...mentioning
confidence: 99%