The Effects of Octylcyanoacrylate on Scarring after Burns

Abstract

Abstract. Objective: To compare the effects of octylcyanoacrylate (OCA), silver sulfadiazine (SSD), polyurethane film (PU), and dry gauze (G) on scarring three months after partial-thickness burns. Methods: This was a prospective, blinded, controlled experimental trial using isoflurane-anesthetized swine. Standardized partial-thickness burns were inflicted by applying an aluminum bar preheated to 80ЊC to the backs and flanks of a young pig for 20 seconds. Four equal sets of ten burns each were randomly treated with OCA spray, SSD, PU, or G. Dressing changes were performed on days 1, 2, 3, and 4 after injury. Digital images of the burns were obtained immediately and three months later for masked computerized determination of scar surface area. Full-thickness biopsies were taken at three months for masked histopathological evaluation. The primary outcome was the percent reduction in residual wound area (RWA) calculated by subtracting the area of each individual burn from the area of the largest burn and dividing this value by the area of the largest burn (intraobserver correlation, r = 0.99). Secondary outcomes were the proportion of burns with the presence of scar tissue (abnormal collagen under polarized light; intraobserver agreement, = 0.93) and the cosmetic appearance on a 100-mm visual analog scale marked ''best scar'' at the high end (interobserver correlation, r = 0.82). Analysis of variance (ANOVA) and 2 tests were used for group comparisons as appropriate. This study had 80% power to detect a 33-percentage-point difference in RWA among groups (␣ = 0.05). Results: A total of 40 burns were inflicted on the pig. There was no difference in percent RWA across the groups (OCA = 25%, SSD = 40%, PU = 25%, G = 32%; p = 0.13). There was no difference in the proportion of wounds with scarring among the groups (OCA = 10%, SSD = 22%, PU = 2%, G = 30%; p = 0.89). There was also no difference in the cosmetic scores among the groups (OCA = 78 mm, SSD = 75 mm, PU = 74 mm, G = 74 mm; p = 0.96). Conclusions:The effects of OCA spray, SSD, PU, and dry gauze on scarring three months after burns in pigs are similar. Key words: partial-thickness burns; scarring; wound contracture; tissue adhesives; silver sulfadiazine; polyurethane film. ACADEMIC EMER- GENCY MEDICINE 2001; 8:107-111 A LTHOUGH the incidence of burns has declined steadily over the past several decades, 1,2 there are still more than 500,000 burns treated in emergency departments (EDs) throughout the United States each year.3 Most such burns are considered minor since they are superficial and cover less than 5% of the total body surface area.

Crocodile Oil Enhances Cutaneous Burn Wound Healing and Reduces Scar Formation in Rats

“…The primary outcome was the percentage of wound contraction. The sizes of the wound areas on the 7th, 10th, 17th, 21st, and 28th days were determined by a balance, and the percentage of wound contraction was calculated by subtracting the surface area of individual burns from the surface area of the largest burn and dividing this value by the surface area of the largest burn multiplied by 100 28 . This outcome had an interobserver correlation of 0.99 on a subset of burns.…”

Development of a Histomorphologic Scale to Quantify Cutaneous Scars after Burns

“…The detailed results of this study are reported elsewhere. 4 Briefly, this study demonstrated similar rates of scarring and wound contracture among the various treatment groups three months after injury.…”

Uso de 2-octil cianoacrilato em anastomose colônica: estudo experimental em ratos wistar

“…A etiologia da toxicidade tecidual destas substâncias é atribuída aos seus produtos de degradação (cianoacetato, formaldeído e hidroperóxidos), que ativam a síntese de prostaglandinas e tromboxanos, participantes da oxidação e lise da membrana celular [15][16][17] . Os cianoacrilatos apresentam propriedades antibacterianas podendo reduzir a incidência de infecções por organismos gram-positivos e alguns gram-negativos quando comparados à sutura com fio monofilamentar 8,14,[18][19][20] . O 2-octil cianoacrilato apresenta ultra-estrutura três vezes mais resistente que seu antecessor, o butil-2 cianoacrilato, com degradação lenta que permite a formação de composto mais forte, com menor desenvolvimento de metabólitos, menor concentração local destas substân-cias, e menor reação tecidual 8,[16][17][18]21 .…”