The effects of omega‐3 fatty acid diet enrichment on wound healing

Scardino,; Swaim,; Sartin,; Hoffman,; Oglivie,; Hanson, Mark D.; Coolman,; Davenport,

doi:10.1046/j.1365-3164.1999.00148.x

Cited by 32 publications

(30 citation statements)

References 30 publications

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“…The results of our study confirmed other findings (Scardino et al, 1999;Cardose et al, 2004;Vure and Avinash, 2006) that showed the application of unsaturated fatty acids like linolenic acid (n-3) can increase inflammatory parameters in the first days after surgery and thus, promote the wound healing. On the other hand, several studies have shown that sheep milk contents of unsaturated fatty acids, essential amino acids and important elements like magnesium, calcium, iron, zinc and Bcomplex vitamins, are two or three times more than those of cow milk and indicated the higher therapeutic effects of sheep milk compared to cow milk (Hardy, 2000).…”

Section: Discussionsupporting

confidence: 92%

Histological evaluation of Curcuma longa–ghee formulation and hyaluronic acid on gingival healing in dog

Habiboallah

Saghravanian

Mahdi

et al. 2008

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 92%

Histological evaluation of Curcuma longa–ghee formulation and hyaluronic acid on gingival healing in dog

Habiboallah

Saghravanian

Mahdi

et al. 2008

Journal of Ethnopharmacology

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“…We used the Abramov's histological scoring system and M. Stacie Scardino study (Abramov et al, 2007;Scardino et al, 2002). Abramov's system assessed each parameter independently and gave it a score of 0-3 (absent=0, Slight=1, moderate=2, extensive=3).…”

Section: Histological Gradingmentioning

confidence: 99%

Albusite: A Novel Synthetic Gel for Promotion of Skin Wound Healing in Rats

Jahanabadi¹,

Karami²,

Paydar³

et al. 2015

OnLine Journal of Biological Sciences

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The current study was performed to evaluate the effect of Albusite gel on the healing process of excisional wounds in diabetic and control rats. Fifty-two Sprague Dawley male rats were used to evaluate the effects of Albusite Gel (synthetic gel) on the healing of full-thickness skin wounds. The control group (n = 2 6) and study group (n = 26) were divided into two groups (n = 13). Wounds were assessed by wound measurements and collection of samples at 9 (A, C) and 21 days (B, D) post-wounding to evaluate the healing process. Variables of interest were gross and microscopic histopathological characteristics were reflective of wound healing. Topical Albusite gel was applied for wound A and B, once a day. Each rat was anesthetized and a round full thickness excisional wound with 150 cm 2 area was performed on the right dorsolateral side of each rat. There was little difference between the case and control groups. Wound healing processes and wound closure in the intervention group began sooner and completed more quickly respectively, but both of them did not show a statistically significant difference (p>0.05). The healing of Albusite treated wound was better than the control wounds grossly. The study wounds were biopsied at days 9 and 21, so this might not show different effects of the Albusite gel group in appropriate time. Therefore, further studies are recommended with more sample size and less biopsy interval.

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“…A limited number of studies have examined the effects of dietary or topical applications of PUFA on wound healing. A cutaneous wound healing study found that rats fed a diet enriched in n -3 fatty acids produced wounds that were weaker in tensile strength compared to those from rats fed a diet containing n -6 fatty acids [19]. Cutaneous wounds in dogs fed an n -3 enriched diet had reduced epithelialization and contraction of open wounds and less edema in sutured wounds after 5 days than dogs fed a diet enriched in n -6 fatty acids.…”

Section: Discussionmentioning

confidence: 99%

Inducible nitric oxide synthase links NF-κB to PGE2 in polyunsaturated fatty acid altered fibroblast in-vitro wound healing

Jia

Turek

2005

Lipids Health Dis

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BackgroundThis study investigated mechanisms of altered fibroblast collagen production induced by polyunsaturated fatty acids. 3T3-Swiss fibroblasts were grown in medium containing either eicosapentaenoic or arachidonic acid. The effects of nuclear factor-kappaB activation by lipopolysaccharide on inducible nitric oxide synthase, nitric oxide, prostaglandin E2, collagen production, and in-vitro wound healing were studied.ResultsEicosapentaenoic acid treated cells produced less prostaglandin E2 but had increased inducible nitric oxide synthase expression, nitric oxide production, collagen formation, and recoverage area during in-vitro wound healing than cells treated with arachidonic acid. Activation of nuclear factor-kappaB with lipopolysaccharide increased inducible nitric oxide synthase expression, the production of nitric oxide, prostaglandin E2, collagen, and the in-vitro wound recoverage area. The nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester, decreased lipopolysaccharide-induced nitric oxide, but the amount of nitric oxide was greater in eicosapentaenoic acid treated cells. NG-nitro-L-arginine methyl ester plus lipopolysaccharide treatment increased collagen production and cellular recoverage area while treatment with NG-nitro-L-arginine methyl ester alone decreased it in wounded fibroblasts.ConclusionThe activation of the NF-κB pathway and PGE2 can be linked by the cross-talk of iNOS and NO in the PUFA altered fibroblast collagen production and wound healing. Additional studies are needed to determine how polyunsaturated fatty acids can be used as adjuvants in combination with other treatments (i.e, drugs) to design therapies to either enhance healthy collagen production or inhibit production and reduce fibrosis.

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The effects of omega‐3 fatty acid diet enrichment on wound healing

Cited by 32 publications

References 30 publications

Histological evaluation of Curcuma longa–ghee formulation and hyaluronic acid on gingival healing in dog

Histological evaluation of Curcuma longa–ghee formulation and hyaluronic acid on gingival healing in dog

Albusite: A Novel Synthetic Gel for Promotion of Skin Wound Healing in Rats

Inducible nitric oxide synthase links NF-κB to PGE2 in polyunsaturated fatty acid altered fibroblast in-vitro wound healing

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