The effects of opiate consumption on serum reproductive hormone levels, sperm parameters, seminal plasma antioxidant capacity and sperm DNA integrity

Safarinejad, Mohammad Reza; Asgari, Seyyed Alaeddin; Farshi, Alireza; Ghaedi, Gholamhossein; Kolahi, Ali‐Asghar; Iravani, Shahrokh; Khoshdel, Alireza

doi:10.1016/j.reprotox.2012.11.010

Cited by 67 publications

(39 citation statements)

References 25 publications

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Section: Alcohol Tobacco and Drugsmentioning

confidence: 98%

“…Opiate addicted men were found to have significantly lower total sperm counts than matched controls (Safarinejad et al ., ), although this finding may be drug specific (Cicero et al ., ). Serum testosterone levels are significantly lower in opiate users (Cicero et al ., ; Safarinejad et al ., ). Additionally, functional δ‐, κ‐, and μ‐opioid receptors have been demonstrated in human spermatozoa (Agirregoitia et al ., ), which may explain decreased motility seen in opiate users and variability in the other semen parameters reported in the literature (Cicero et al ., ; Safarinejad et al ., ).…”

Section: Alcohol Tobacco and Drugsmentioning

confidence: 98%

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Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis

2016

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SUMMARYSeveral recent studies have suggested that sperm concentrations and semen quality have been decreasing over the past several decades in many areas of the world. The etiology of these decreases is currently unknown. Acute events can have significant impacts on spermatogenesis and are often readily identified during the male fertility evaluation. The majority of male factor infertility, however, is idiopathic. Chronic, low-dose exposures to chemicals and nutrients are more difficult to identify, but are extremely prevalent. These exposures have been shown to have dramatic effects on both individual and community health and interest in the cumulative and synergistic impacts of such agents on spermatogenesis has been increasing. While our understanding of these potential hazards is evolving, it is clear that they may significantly influence male reproductive potential. This review explores the literature related to effects of chronic exposures from drug use, dietary intake, and the environment on spermatogenesis in humans and animals.

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Section: Alcohol Tobacco and Drugsmentioning

confidence: 98%

Section: Alcohol Tobacco and Drugsmentioning

confidence: 98%

Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis

2016

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“…It is also demonstrated that MA adversely affects on seminiferous epithelium including degeneration and apoptosis of germ cells (12). It is also suggested that MA affects male reproductive function at multiple levels due to its effects on the endocrine control of spermatogenesis (13, 14). Recently, it has been reported that MA decreases normal sperm morphology and count, as well as increase apoptotic cells in seminiferous tubules (15, 16).…”

Section: Introductionmentioning

confidence: 99%

Administration of high dose of methamphetamine has detrimental effects on sperm parameters and DNA integrity in mice

Sabour

Khoradmehr

Kalantar

et al. 2017

IJRM

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Background:Methamphetamine (MA) was shown to have harmful effects on male reproductive system. Objective:To investigate probable effects of daily administration of MA on sperm parameters and chromatin/DNA integrity in mouse.Material and Methods:Thirty-five NMRI male mice were divided into five groups including low, medium, and high dosage groups which were injected intraperitoneally with 4, 8 and 15 mg/kg/day for 35 days, respectively. Normal saline was injected in sham group and no medications were used in control group. Then, the mice were killed and caudal epididymis of each animal was cut and placed in Ham’s F10 medium for sperm retrieval. To evaluate sperm chromatin abnormalities, the aniline blue, toluidine blue and chromomycine A3 were used. For sperm DNA integrity and apoptosis, the acridine orange, sperm chromatin dispersion, and TUNEL assay were applied. For sperm morphology, Papanicolaou staining was done Results:Normal morphology and progressive motility of spermatozoa decreased in medium and high dosage groups in comparison with the control group (p=0.035). There was a significant increase in rate of aniline blue, toluidine blue, and chromomycine A3 positive spermatozoa in high dosage group. In a similar manner, there was an increase in rates of acridine orange, TUNEL and sperm chromatin dispersion positive sperm cells in high dosage group with respect to others.Conclusion:MA abuse in a dose-dependent manner could have detrimental effects on male reproductive indices including sperm parameters and sperm chromatin/DNA integrity in mice.

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“…However, only a few studies have explored the effect of male drug use on the fertility and reproductive health of their female partners. A study in Iran with opiate users reported a significant association and dose response between opiate consumption and impaired sperm parameters and sperm chromatin damage (Safarinejada et al 2013). Other studies report that abnormal or poor quality sperm can result in infertility or unstable pregnancies resulting in abortions (Cicero et al 1975;Gil-Villa et al 2010).…”

Section: Discussionmentioning

confidence: 99%

‘Women at risk’: the health and social vulnerabilities of the regular female partners of men who inject drugs in Delhi, India

Sharma

Sarna

Luchters

et al. 2014

Culture, Health & Sexuality

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Needle and syringe sharing is common among people who inject drugs and so is unprotected sex, which consequently puts their sex partners at risk of sexually transmitted infections (STIs) including HIV and other blood-borne infections, like hepatitis. We undertook a nested study with the regular female partners of men who inject drugs participating in a longitudinal HIV incidence study in Delhi, India. In-depth interviews were conducted with female partners of 32 men. The interviews aimed to gather focused and contextual knowledge of determinants of safe sex and reproductive health needs of these women. Information obtained through interviews was triangulated and linked to the baseline behavioural data of their partner (index men who injected drugs). The study findings illustrate that women in monogamous relationships have a low perception of STI- and HIV-related risk. Additionally, lack of awareness about hepatitis B and C is a cause of concern. Findings also suggest impact of male drug use on the fertility of the female partner. It is critical to empower regular female partners to build their self-risk assessment skills and self-efficacy to negotiate condom use. Future work must explore the role of drug abuse among men who inject drugs in predicting fertility and reproductive morbidity among their female partners.

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The effects of opiate consumption on serum reproductive hormone levels, sperm parameters, seminal plasma antioxidant capacity and sperm DNA integrity

Cited by 67 publications

References 25 publications

Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis

Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis

Administration of high dose of methamphetamine has detrimental effects on sperm parameters and DNA integrity in mice

‘Women at risk’: the health and social vulnerabilities of the regular female partners of men who inject drugs in Delhi, India

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