The Effects of Oral Antibiotics on Infection Prophylaxis in Traumatic Wounds

Abstract

BACKGROUND:The objective of this study is to examine the effectiveness of oral antibiotics in the prevention of infection development in traumatic wounds.

Prophylactic antibiotics prescription in ear, nose, throat and ophthalmologic procedures; an Iranian university hospital situational analysis

“…Different prophylactic methods have been described to prevent postoperative Surgical Site Infection (SSI) (1)(2)(3)(4)(5), all aimed to reinforce host agents against enormous endogenous and exogenous bacterial colonization and following infection at sites of surgery (2,5). Although SSI prophylaxis has been accepted and very commonly considered since 20 years ago, but it is a fact that prevalence of SSI is even high.…”

“…Although SSI prophylaxis has been accepted and very commonly considered since 20 years ago, but it is a fact that prevalence of SSI is even high. For example, in terms of extra-abdominal procedures, SSI reaches to 5% and more while it is over than 20% in intra-abdominal surgeries, additionally, reports showed the prevalence even up to 38% (1)(2)(3). This may increase risk of needing intensive care by 60%, recurrent admissions and mortality rate of five and two-fold, respectively (6).…”

“…Conclusively, study reports showed that the lower the incidence of SSI, the lower the medical cost imposed, both for patients and country health system (2,3,6,7). Prescription of prophylactic antibiotics (PA) is one of common preventive methods for SSI (1,2,(8)(9)(10)(11)(12). Although based on American Society of Health Protection (ASHP) instructions, protocols of using antibiotics have been recommended for SSI prophylaxis in different procedures, but there is no comprehensive consensus on how and which antibiotics should be whether use or not that prevent SSI incidence in borderline clean-contaminated procedures (8).…”

“…Although based on American Society of Health Protection (ASHP) instructions, protocols of using antibiotics have been recommended for SSI prophylaxis in different procedures, but there is no comprehensive consensus on how and which antibiotics should be whether use or not that prevent SSI incidence in borderline clean-contaminated procedures (8). This issue may be more controversial when some studies reported that the lower adequacy of using prophylactic antibiotics whether in type selection or first dose injection, could generate resistant species (1)(2)(3) and also increase risk of SSI by 2-fold in specific age groups (7) beside of making patients to stay more time in hospital, suffer from drug adverse effects and give more money (2,3). It is while based on ASHP guidelines prescription of therapeutic antibiotics in combination with prophylactic dosage is absolutely indicated for contaminated and dirty wounds (8).…”

Early prevention of trauma-related infection/sepsis

“…The administration of oral antibiotics is often applied to prevent wound infection for simple traumatic wounds [32, 33]. In addition, antibiotic ointments containing bacitracin, polymyxin, neomycin or cetrimide are often used in minor uncomplicated soft tissue wounds and have lower skin infection rates [34].…”