The Effects of Oral Doses of Theophylline and Fenoterol on Exercise-Induced Asthma

Eggleston, Peyton A.; Beasley, P.; Kindley, Robert T.

doi:10.1378/chest.79.4.399

Cited by 11 publications

(2 citation statements)

References 18 publications

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“…theophyllines) can reinforce the side effects of both drugs. This phe nomenon is more marked after oral ad ministration than after administration by inhalation [13][14][15]. However, a cautious oral therapy can be useful, for example when an inhalation treatment is not com pletely effective or cannot be used prop erly.…”

Section: Discussionmentioning

confidence: 99%

Broxaterol (Z.1170), a New Oral β2-Agonist Compared with Salbutamol

Perruchoud¹,

Bründler²,

Godly³

et al. 1987

Respiration

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The bronchodilating activity and tolerability of a single 0.5-mg oral dose of broxaterol (Z.1170) were evaluated in 18 patients with reversible bronchial obstruction. Salbutamol 4.0 mg and placebo were used as controls. The study design was double-blind within patients. The forced expiratory volume in 1 s (FEV₁), pulse rate, and blood pressure were measured immediately before and 0.5, 1, 2, 3,4, 5, and 6 h after each treatment. At the same time clinical controls were made to detect the possible presence of side effects. Both broxaterol and salbutamol caused significant increases in FEV₁ until the 5th hour as compared to baseline values and until the 2nd hour as compared to placebo. No significant difference was reported between the effects of broxaterol and those of salbutamol at all the times considered. The tolerability of broxaterol was good, as was that of salbutamol. The pulse rate and blood pressure did not show any significant clinical variations. The side effect reported most frequently was tremor.

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Section: Discussionmentioning

confidence: 99%

Broxaterol (Z.1170), a New Oral β2-Agonist Compared with Salbutamol

Perruchoud¹,

Bründler²,

Godly³

et al. 1987

Respiration

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“…Some authors, using different doses of the two agents, different routes of administration, and in different types of subjects both children and adults, do find valuable interaction (Wolfe et al, 1978;Campbell et al, 1977;Lonnerholm, Foucard and Lindstrom, 1981;Leitch et aL, 1981), whereas others, again using different patients, and different combinations of the two agents, do not (Eggleston, Beasley and Kindley, 1981;Handslip, Dart and Davis, 1981). As with many studies in asthmatics, the variability of airflow limitation, the very hallmark of asthma, renders statistically valid comparisons difficult, and often means that only patients with relatively stable airflow limitation are studied.…”

Section: Oral Theophyllines In Asthmamentioning

confidence: 99%

Recent advances in respiratory medicine

Flenley

1983

Postgraduate Medical Journal

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In the past tuberculosis so dominated both public and professional views of respiratory medicine that it seemed obvious that the speciality must atrophy, at least in developed countries, when effective therapy for tuberculosis became available. The reality has been rather different. New discoveries in understanding of pathogenesis, in diagnostic methods, and above all in treatment, continue to keep respiratory medicine to the fore amongst the major sub-specialities of medicine, a position that the burden of such disease on society clearly merits. The topics chosen for this review are necessarilv personal, but aim to indicate some areas where these discoveries are being applied in clinical practice today.

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Beta₂-agonists for exercise-induced asthma

Bonini

Mambro

Calderón

et al. 2013

Cochrane Database of Systematic Reviews

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The Effects of Oral Doses of Theophylline and Fenoterol on Exercise-Induced Asthma

Cited by 11 publications

References 18 publications

Broxaterol (Z.1170), a New Oral <i>β</i><sub>2</sub>-Agonist Compared with Salbutamol

Broxaterol (Z.1170), a New Oral <i>β</i><sub>2</sub>-Agonist Compared with Salbutamol

Recent advances in respiratory medicine

Beta₂-agonists for exercise-induced asthma

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The Effects of Oral Doses of Theophylline and Fenoterol on Exercise-Induced Asthma

Cited by 11 publications

References 18 publications

Broxaterol (Z.1170), a New Oral <i>β</i><sub>2</sub>-Agonist Compared with Salbutamol

Broxaterol (Z.1170), a New Oral <i>β</i><sub>2</sub>-Agonist Compared with Salbutamol

Recent advances in respiratory medicine

Beta2-agonists for exercise-induced asthma

Contact Info

Product

Resources

About

Beta₂-agonists for exercise-induced asthma