The effects of orally administered linoleic acid and its autoxidation products on intestinal mucosa in rat.

Kanazawa, Kazuki; Ashida, Hitoshi; Minamoto, Shinsuke; Danno, Gen-ichi; Natake, Masato

doi:10.3177/jnsv.34.363

Cited by 15 publications

(8 citation statements)

References 27 publications

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“…The observed 9 % reduction in BW gain (when comparing 0 and 12 d of peroxidation) was largely the result of reduced feed intake (7 % reduction when comparing 0 and 12 d), but it could also be related to enterocyte dysfunction, oxidative stress and so on. Kanazawa et al (7) concluded that lipid peroxidation impaired the functionality of the intestine as indicated by decreased enzyme activity (sucrase, maltase and alkaline phosphatase) in the jejunum and ileum after oral administration of products of peroxidation of linoleic acid to rats. In the current study, the improvement in daily BW gain because of the addition of unexposed soyabean oil when compared with the control diet was progressively diminished as the degree of peroxidation increased.…”

Section: Discussionmentioning

confidence: 99%

“…Understanding the effects of lipid peroxidation in the small intestine is particularly important because intestinal epithelial cells experience greater exposure to lipid peroxidation products. Early research provided evidence of the toxicity of peroxidised lipid products ( 6 , 7 ) and cautioned their use in livestock feeds because this could result in a reduction of productivity ( 8 , 9 ) . Recent studies investigated the deleterious effects of hydroperoxides, aldehydes and other lipid peroxidation subproducts on intestinal cell lines ( 2 , 10 ) and animals ( 7 , 11 , 12 ) .…”

mentioning

confidence: 99%

“…Early research provided evidence of the toxicity of peroxidised lipid products ( 6 , 7 ) and cautioned their use in livestock feeds because this could result in a reduction of productivity ( 8 , 9 ) . Recent studies investigated the deleterious effects of hydroperoxides, aldehydes and other lipid peroxidation subproducts on intestinal cell lines ( 2 , 10 ) and animals ( 7 , 11 , 12 ) . Dietary peroxidised lipids can induce oxidative stress and impair the antioxidant defence system ( 11 , 13 ) .…”

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Peroxidised dietary lipids impair intestinal function and morphology of the small intestine villi of nursery pigs in a dose-dependent manner

et al. 2015

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The objective of this study was to investigate the effect of increasing degrees of lipid peroxidation on structure and function of the small intestine of nursery pigs. A total of 216 pigs (mean body weight was 6·5 kg) were randomly allotted within weight blocks and sex and fed one of five experimental diets for 35 d (eleven pens per treatment with three to four pigs per pen). Treatments included a control diet without added lipid, and diets supplemented with 6 % soyabean oil that was exposed to heat (80°C) and constant oxygen flow (1 litre/min) for 0, 6, 9 and 12 d. Increasing lipid peroxidation linearly reduced feed intake (P < 0·001) and weight gain (P = 0·024). Apparent faecal digestibility of gross energy (P = 0·001) and fat (P < 0·001) decreased linearly as the degree of peroxidation increased. Absorption of mannitol (linear, P = 0·097) and D-xylose (linear, P = 0·089), measured in serum 2 h post gavage with a solution containing 0·2 g/ml of D-xylose and 0·3 g/ml of mannitol, tended to decrease progressively as the peroxidation level increased. Increasing peroxidation also resulted in increased villi height (linear, P < 0·001) and crypt depth (quadratic, P = 0·005) in the jejunum. Increasing peroxidation increased malondialdehyde concentrations (quadratic, P = 0·035) and reduced the total antioxidant capacity (linear, P = 0·044) in the jejunal mucosa. In conclusion, lipid peroxidation progressively diminished animal performance and modified the function and morphology of the small intestine of nursery pigs. Detrimental effects were related with the disruption of redox environment of the intestinal mucosa.

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Peroxidised dietary lipids impair intestinal function and morphology of the small intestine villi of nursery pigs in a dose-dependent manner

et al. 2015

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“…As to effects of hydroperoxides on intestinal mucosa, Kanazawa and coworkers (Kanazawa et al 1988) examined their potential toxicity by measuring activities of sucrase, maltase, and alkaline phosphatase, which refl ect the integrity and function of the brush border membrane. They found that hydroperoxides decreased enzyme activities in jejunum and ileum.…”

Section: Enzymatic Hydrolysis and Absorption Of Oxidized Dietary Lipidsmentioning

confidence: 99%

Changes and Effects of Dietary Oxidized Lipids in the Gastrointestinal Tract

Márquez‐Ruiz¹,

Garcı́a-Martı́nez²,

Holgado³

2008

Lipid�Insights

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This paper is focused on the present state-of-the art of modifi cations and effects of dietary oxidized lipids during their transit along the gastrointestinal tract. A survey of the literature reporting changes and effects of oxidized lipids before absorption, fi rst in the stomach and then during enzymatic lipolysis in the small intestine, are addressed. Also, the fate of non-absorbed compounds and their potential implications at the colorectal level are discussed. Among the results found, it is shown that acidic gastric conditions and the infl uence of other dietary components may lead to either further oxidation or antioxidative effects in the stomach. Also, changes in oxidized functions, especially of hydroperoxy and epoxy groups, seem likely to occur. Enzymatic hydrolysis by pancreatic lipase is not effective for triacylglycerol polymers, and hence they can be found as non-absorbed oxidized lipids in the large intestine. Interactions of oxidized lipids with cholesterol absorption in the small intestine and with microfl ora metabolism have been also observed.

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“…Esto explicaría la mejora observada por Thacker (23) cuando micronizó la canola integral. Finalmente, otra posible causa es la presencia de grasa peroxidada, porque afecta la capacidad de absorción del intestino delgado y modifica la morfología intestinal al alterar el potencial redox a nivel luminal (30) , afectando in vivo la membrana del enterocito, e in vitro la actividad de las enzimas sacarasa, maltasa y fosfatasa alcalina (31) . La molienda de la semilla de canola pudo favorecer este efecto porque no se utilizaron antioxidantes durante ese proceso.…”

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Determination of the digestibility of the protein, amino acids and energy of full fat canola in growing pigs

Landín

Rodríguez

2017

Rev. Mex. Cienc. Pecu.

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Determinación de la digestibilidad de la proteína, aminoácidos y energía de canola integral en cerdos en crecimiento Determination of the digestibility of the protein, amino acids and energy of full fat canola in growing pigsGerardo Mariscal-Landín a *, Erika Ramírez Rodríguez a RESUMENPara evaluar el uso de canola integral en la alimentación de cerdos se realizaron dos experimentos. En el primero se evaluó la digestibilidad aparente y estandarizada a nivel ileal (DAI y DEI) de la materia seca (MS), proteína (PC), aminoácidos (AA) y energía (E); en el segundo se evaluó la digestibilidad aparente fecal (DAF) de la PC y E. En ambos experimentos se evaluaron dos dietas de canola integral, una con canola integral molida más almidón de maíz (CIM-AM) y otra con canola integral y sorgo molidos juntos (CISM). Los resultados muestran que la DAI de la MS (71.4), PC (54.9) y E (67.6) fue similar (P>0.10) en ambas dietas. La DAI y DEI difirieron en los aminoácidos alanina y leucina (P<0.001), fenilalanina, ácido glutámico, histidina y valina (P<0.01), y la DEI de serina (P<0.05). La mayor digestibilidad se observó en la dieta CISM. La DAF de la MS y PC (P<0.001) y de E (P<0.01) fueron menores en la dieta CISM. Se concluye que la DAI de la proteína y aminoácidos, así como la DAF de la energía, son bajas en la canola integral molida, lo que reduce la posibilidad de incluirla en dietas para cerdos. Sin embargo, la molienda de canola integral junto con el sorgo mejoró la digestibilidad aparente de los aminoácidos de la mezcla, lo que permitiría utilizar esa mezcla como un ingrediente en la formulación de raciones. PALABRAS CLAVE: Canola integral, Energía, Aminoácidos, Digestibilidad, Cerdos. ABSTRACTTwo experiments were carried out to evaluate in pigs the use of full-fat canola. In the first one apparent and standardized ileal digestibility (AID and SID) of dry matter (DM), crude protein (CP), amino acids (AA) and energy (E) were evaluated in twelve pigs. In the second one apparent fecal digestibility (AFD) of CP and E were evaluated in eight pigs. In both experiments, full-fat canola (FFC) was used to prepare two diets, a full-fat canola milled and corn starch diet (FFCM-CS), and another with full-fat canola and sorghum milled together (FFCSM). The results show that AID of DM (71.4), CP (54.9) and E (67.6) was similar (P>0.10) between the two diets. SID and AID differ in alanine and leucine (P<0.001), phenylalanine, glutamic acid, histidine and valine (P<0.01); and The SID of serine (P<0.05). In all cases, the higher digestibility was observed in the FFCSM diet. The AFD of DM and CP (P<0.001), and E were lower (P<0.01) in FFCSM diet than in FFCM-CS diet. It is concluded that AID and SID of protein and amino acids, as well as AFD of energy, are low in full-fat canola, reducing the possibility of its inclusion in diets for pigs. However, the mix of full-fat canola and sorghum milled together improved apparent ileal digestibility of amino acids allowing its use as an ingredient in the formulation of rations.

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The effects of orally administered linoleic acid and its autoxidation products on intestinal mucosa in rat.

Cited by 15 publications

References 27 publications

Peroxidised dietary lipids impair intestinal function and morphology of the small intestine villi of nursery pigs in a dose-dependent manner

Peroxidised dietary lipids impair intestinal function and morphology of the small intestine villi of nursery pigs in a dose-dependent manner

Changes and Effects of Dietary Oxidized Lipids in the Gastrointestinal Tract

Determination of the digestibility of the protein, amino acids and energy of full fat canola in growing pigs

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