The effects of organic and inorganic lead and mercury on neurotransmitter high-affinity transport and release mechanisms

Bondy, Stephen C.; Anderson, C. L.; Harrington, Marilyn E.; Prasad, Kedar N.

doi:10.1016/0013-9351(79)90038-0

Cited by 86 publications

(18 citation statements)

References 22 publications

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“…Previous studies found that MeHg induced stimulation on the spontaneous release of monoamines from different experimental CNS tissue preparations (Bondy et al, 1979;Komulainen and Tuomisto, 1981;Minnema et al, 1989). Under some experimental conditions, MeHg also proved to be an inhibitor of the uptake of monoamines from rat brain synaptosomes (Komulainen and Tuomisto, 1981).…”

Section: Discussionmentioning

confidence: 95%

Effects of Methyl Mercury on thein VivoRelease of Dopamine and Its Acidic Metabolites DOPAC and HVA from Striatum of Rats

Faro

Durán

Nascimento

et al. 1997

Ecotoxicology and Environmental Safety

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Section: Discussionmentioning

confidence: 95%

Effects of Methyl Mercury on thein VivoRelease of Dopamine and Its Acidic Metabolites DOPAC and HVA from Striatum of Rats

Faro

Durán

Nascimento

et al. 1997

Ecotoxicology and Environmental Safety

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“…Bondy et al (11) reported that tributyl lead inhibited HACU more effectively than did lead acetate. They speculated that the heavy metal in organometalic compounds is able to dissolve in and diffuse through lipid-rich membranes more easily than the lead supplies as lead acetate.…”

Section: Resultsmentioning

confidence: 99%

“…Bondy and his colleagues (11)(12)(13) reported that tri-n-butyl lead inhibited the high-affinity uptake of choline (HACU) and the binding of…”

mentioning

confidence: 99%

Effects of triethyl lead on various cholinergic parameters in the rat brain in vitro.

Hoshi¹,

Kobayashi

Yuyama

et al. 1991

Jpn.J.Pharmacol

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ABSTRACT-The effects of triethyl lead acetate (triethyl Pb) on the cholinergic system in the brain of the rats were investigated in vitro. Triethyl Pb, at concentrations below 10-4 M, inhibited the depolarized release of acetylcholine (ACh) from slices of cortex and they synthesis of ACh in such slices, while it potentiated in a dose-dependent manner the non-depolarized release of ACh. In contrast, lead inhibited noncompetitively the high-affinity uptake of choline into synaptosomes with a Ki of 4.03 X 10-6 M and the activity of choline acetyltransferase with a Ki of 4.07 X 105 M. Triethyl Pb has an inhibitory effect (IC50 = 5 X 10-5 M) on the binding of [3H]quinuclidinyl benzilate to muscarinic ACh receptors. Triethyl Pb inhibited acetylcholinesterase activity slightly at 5 X 105 and 10-4 M. It is suggested that ACh transmission, in particular the synthesis of ACh and the release of ACh, is susceptible to organolead neurotoxicity.

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“…It has been suggested that tributyltin and trimethyltin affect the HACU via some component(s) other than sulfhydryl groups, but methylmercury acts via sulfhydryl groups in or around the transporter (19,23,26). Tributyltin was, however, found previously to be about 14-fold more potent than trimethyltin, which has a lower solubility in lipids than tributyltin, in inhibiting the HACU (19).…”

Section: Effects On the Activity Of Choline Acetyltransferasementioning

confidence: 99%

Effects of Tri-, Di and Monobutyltin on Synaptic Parameters of the Cholinergic System in the Cerebral Cortex of Mice

Kobayashi¹,

Suzuki²,

Kasashima³

et al. 1996

Japanese Journal of Pharmacology

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ABSTRACT-Triorganotin compounds like tributyltin have been reported to be biodegraded to diorganotin, monoorganotin and then inorganic tin in animals after they have been ingested. Effects of tributyltin, dibutyltin and monobutyltin on various cholinergic parameters that are involved in synaptic transmission in the mouse cerebral cortex were investigated in vitro. Tributyltin and dibutyltin, but not monobutyltin, inhibited the activity of choline acetyltransferase, both the high-affinity and low-affinity uptakes of choline into synaptosomes, and the binding of [3H]quinuclidinyl benzilate to muscarinic acetylcholine receptors. Tributyltin and dibutyltin, but not monobutyltin, had a slightly suppressive effect on the K+-induced release and synthesis of acetylcholine in slices of the cortex. All three butyltins at concentrations from 10-6 to 10-4 M had no effect on the activity of acetylcholinesterase. The extent of the inhibitory effects on the cholinergic parameters, apart from the activity of acetylcholinesterase, was slightly greater in the case of tributyltin than dibutyltin, in particularly at the highest concentration (10-4 M) tested. Therefore, it is concluded that tributyltin metabolites inhibit various parameters of cholinergic activity with a potency ranking of tributyltin > dibutyltin > monobutyltin.

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The effects of organic and inorganic lead and mercury on neurotransmitter high-affinity transport and release mechanisms

Cited by 86 publications

References 22 publications

Effects of Methyl Mercury on thein VivoRelease of Dopamine and Its Acidic Metabolites DOPAC and HVA from Striatum of Rats

Effects of Methyl Mercury on thein VivoRelease of Dopamine and Its Acidic Metabolites DOPAC and HVA from Striatum of Rats

Effects of triethyl lead on various cholinergic parameters in the rat brain in vitro.

Effects of Tri-, Di and Monobutyltin on Synaptic Parameters of the Cholinergic System in the Cerebral Cortex of Mice

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