The effects of ovariectomy on binge eating proneness in adult female rats

Klump, Kelly L.; Suisman, Jessica L.; Culbert, Kristen M.; Kashy, Deborah A.; Keel, Pamela K.; Sisk, Cheryl L.

doi:10.1016/j.yhbeh.2011.02.015

Cited by 52 publications

(67 citation statements)

References 45 publications

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“…This observation is in line with earlier reports that OVX rats show potentiated binge-like eating compared with gonad-intact female rats (12), while replacement with 17β-estradiol and progesterone suppresses binge-like eating in female OVX rats (13). Here, we further pinpointed that estrogen replacement alone can efficiently suppress bingelike eating behavior in female mice.…”

Section: Discussionsupporting

confidence: 93%

“…Interestingly, circulating 17β-estradiol levels are inversely associated with binge eating in women (7)(8)(9)(10)(11). Consistently, removal of endogenous ovarian hormones by ovariectomy (OVX) potentiates binge eating in female rats (12), whilereplacement with 17β-estradiol and progesterone in OVX rats suppresses binge eating (13). While these data suggest that hormone replacement therapy could be used to suppress binge-like eating, at least in women, the clinical application of ovarian hormones, e.g., estrogens, is limited by their gynecological and tumor-promoting actions.…”

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice

Cao¹,

Xu²,

Oyola³

et al. 2014

J. Clin. Invest.

109

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 90%

Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice

Cao¹,

Xu²,

Oyola³

et al. 2014

J. Clin. Invest.

109

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“…In another study (393), they detected significant heritability for disordered eating in 10 -15-yr-old girls with higher plasma estradiol levels, but not in girls with lower estradiol levels. Pursuing these effects in a rat model, they found that a binge-eating trait emerged in vulnerable rats during puberty (398), but that ovariectomizing these rats increased binge size rather than eliminating binges (397). Taken together, these data suggest that 1) an organizational effect of estrogens at puberty acts on a genetically determined vulnerability to facilitate the development of bingeing in girls and 2) an activational effect of estrogens thereafter may limit binging (please see Ref.…”

Section: R1245 Sex Differences In the Physiology Of Eatingmentioning

confidence: 96%

Sex differences in the physiology of eating

Asarian

Geary²

2013

American Journal of Physiology-Regulatory, Integrative and Comp

414

349

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(HPG) axis function fundamentally affects the physiology of eating. We review sex differences in the physiological and pathophysiological controls of amounts eaten in rats, mice, monkeys, and humans. These controls result from interactions among genetic effects, organizational effects of reproductive hormones (i.e., permanent early developmental effects), and activational effects of these hormones (i.e., effects dependent on hormone levels). Male-female sex differences in the physiology of eating involve both organizational and activational effects of androgens and estrogens. An activational effect of estrogens decreases eating 1) during the periovulatory period of the ovarian cycle in rats, mice, monkeys, and women and 2) tonically between puberty and reproductive senescence or ovariectomy in rats and monkeys, sometimes in mice, and possibly in women. Estrogens acting on estrogen receptor-␣ (ER␣) in the caudal medial nucleus of the solitary tract appear to mediate these effects in rats. Androgens, prolactin, and other reproductive hormones also affect eating in rats. Sex differences in eating are mediated by alterations in orosensory capacity and hedonics, gastric mechanoreception, ghrelin, CCK, glucagon-like peptide-1 (GLP-1), glucagon, insulin, amylin, apolipoprotein A-IV, fatty-acid oxidation, and leptin. The control of eating by central neurochemical signaling via serotonin, MSH, neuropeptide Y, Agouti-related peptide (AgRP), melanin-concentrating hormone, and dopamine is modulated by HPG function. Finally, sex differences in the physiology of eating may contribute to human obesity, anorexia nervosa, and binge eating. The variety and physiological importance of what has been learned so far warrant intensifying basic, translational, and clinical research on sex differences in eating.neuroendocrinology; estrogens; testosterone; eating disorders; obesity SEX DIFFERENCES ARE PERVASIVE in physiology and medicine (51,64,73,109,110,466,797,826). The controls of eating and energy homeostasis are no exceptions. It was observed approximately 100 years ago that removal of the ovaries leads to marked accretion of adipose tissue in rats (697), that daily food intake expressed as kilocalories per gram body weight differs between male and female rats (778), and that food intake varies regularly through the ovarian cycle in intact female rats (674, 779). Sex differences in eating have been the subject of physiological research ever since. The clinical relevance of this work is increasingly evident. In the United States, women are approximately threefold more vulnerable than men to psychiatric eating disorders (346,351) and approximately twofold more vulnerable to severe and morbid obesity (BMI Ն 35 and 40 kg/m 2 , respectively, mass/height 2 ) (226). Women also appear to suffer more from these disorders in terms of physical and psychological functioning and quality of life (24,84,273,292,465,531,762). The increased obesity burden suffered by women is reflected in the fact that Ͼ80% of bariatric surgery patients in the U...

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“…Specifically, removal of the source of ovarian hormones through bilateral ovariectomy in rats causes increased food intake, and adminstration of estradiol reverses this effect. In contrast, progesterone causes increased food intake, in part, by antagonizing the inhibitory effects of estradiol (6–8). …”

mentioning

confidence: 99%

The effects of ovarian hormones and emotional eating on changes in weight preoccupation across the menstrual cycle

Hildebrandt

Racine

Keel

et al. 2014

Intl J Eating Disorders

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Objective Previous research has shown that fluctuations in ovarian hormones (i.e., estradiol and progesterone) predict changes in binge eating and emotional eating across the menstrual cycle. However, the extent to which other eating disorder symptoms fluctuate across the menstrual cycle and are influenced by ovarian hormones remains largely unknown. The current study sought to examine whether levels of weight preoccupation vary across the menstrual cycle and whether changes in ovarian hormones and/or other factors (i.e., emotional eating, negative affect) account for menstrual-cycle fluctuations in this eating disorder phenotype. Method For 45 consecutive days, 352 women ages 15–25 provided daily ratings of weight preoccupation, negative affect, and emotional eating. Daily saliva samples also were collected and assayed for estradiol and progesterone levels using enzyme-immunoassay techniques. Results Weight preoccupation varied significantly across the menstrual cycle, with the highest levels in the pre-menstrual and menstrual phases. However, ovarian hormones did not account for within-person changes in weight preoccupation across the menstrual cycle. Instead, the most significant predictor of menstrual-cycle changes in weight preoccupation was changes in emotional eating. Discussion Fluctuations in weight preoccupation across the menstrual cycle appear to be influenced primarily by emotional eating rather than ovarian hormones. Future research should continue to examine relationships among ovarian hormones, weight preoccupation, emotional eating, and other core eating disorder symptoms (e.g., body dissatisfaction, compensatory behaviors) in an effort to more fully understand the role of these biological and behavioral factors for the full spectrum of eating pathology.

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The effects of ovariectomy on binge eating proneness in adult female rats

Cited by 52 publications

References 45 publications

Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice

Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice

Sex differences in the physiology of eating

The effects of ovarian hormones and emotional eating on changes in weight preoccupation across the menstrual cycle

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