The effects of P2X7 receptor knockout on emotional conditions over the lifespan of mice

Gao, Liangcai; Lin, Zejie; Xie, Guixiang; Zhou, Tian; Hu, Wenhao; Liu, Chi; Liu, Xinnan; Wang, Xinyi; Qian, Min; Ni, Bing

doi:10.1097/wnr.0000000000001136

Cited by 8 publications

(6 citation statements)

References 23 publications

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“…P2X7 receptor is ubiquitous in nearly all tissues and organs including the brain, and numbers of studies suggest P2X7 receptor as a potential therapeutic target for depression 30‐34 . Boucher et.al found that P2X7 knockout mice exhibited an impaired adaptive coping response to repeated stress and thus suggested the P2X7R may be involved in the adaptive mechanisms elicited by exposure to repeated environmental stressors that leads to the development of depression‐like behaviors 32 .…”

Section: Discussionmentioning

confidence: 99%

Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge

Kong

Wang

et al. 2020

Genes Brain and Behavior

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P2X2 and P2X3 receptors are widely expressed in both the peripheral nervous system and the central nervous system and have been proven to participate in different peripheral sensory functions, but there are few studies on the involvement of P2X2 and P2X3 receptors in animal behaviors. Here we used P2X2 and P2X3 knockout mice to address this issue. P2X2 knockout mice showed normal motor function, exploratory behavior, anxiety‐like behaviors, learning and memory behaviors and passive coping response to behavioral challenge. Nevertheless, the effect of ATP infusion in the medial prefrontal cortex (mPFC) on the passive coping response was blocked by P2X2 but not P2X3 receptor deletion. Additionally, no deficits in a wide variety of behavioral tests were observed in P2X3 knockout mice. These findings demonstrate a role of P2X2 receptor in the mPFC in adenosine‐5′‐triphosphate modulation of the passive coping response to behavioral challenge and show that the P2X2/P2X3 receptor is dispensable for behaviors.

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Section: Discussionmentioning

confidence: 99%

Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge

Kong

Wang

et al. 2020

Genes Brain and Behavior

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“…P2 × 7R was the first P2R family member to be discovered, and it is involved in the immune response [ 8 ]. It is expressed in the hematopoietic immune and intrinsic cells of the nervous system, including macrophages, microglia, neurons, astrocytes, and oligodendrocytes [ 23 ].…”

Section: Structure Of P2 × 7rmentioning

confidence: 99%

Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties

Hu,

Luo,

Zhu

et al. 2023

Cell Biosci

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Neurodegenerative diseases seriously affect patients’ physical and mental health, reduce their quality of life, and impose a heavy burden on society. However, their treatment remains challenging. Therefore, exploring factors potentially related to the pathogenesis of neurodegenerative diseases and improving their diagnosis and treatment are urgently needed. Recent studies have shown that P2 × 7R plays a crucial role in regulating neurodegenerative diseases caused by neuroinflammation. P2 × 7R is an adenosine 5′-triphosphate ligand-gated cation channel receptor present in most tissues of the human body. An increase in P2 × 7R levels can affect the progression of neurodegenerative diseases, and the inhibition of P2 × 7R can alleviate neurodegenerative diseases. In this review, we comprehensively describe the biological characteristics (structure, distribution, and function) of this gene, focusing on its potential association with neurodegenerative diseases, and we discuss the pharmacological effects of drugs (P2 × 7R inhibitors) used to treat neurodegenerative diseases.

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“…Besides classical targeting strategies, approaches involving transgenic short hairpin RNA-based knock-down ( Delic et al, 2008 ) and CRISPR/Cas9-mediated gene deletion have also been used to disrupt P2X7R expression and function ( Gao et al, 2018 ).…”

Section: Genetic Mouse Models Targeting P2x7rmentioning

confidence: 99%

P2X7 Receptor-Related Genetic Mouse Models – Tools for Translational Research in Psychiatry

Urbina-Treviño

Mücke-Heim

Deussing

2022

Front. Neural Circuits

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Depression is a common psychiatric disorder and the leading cause of disability worldwide. Although treatments are available, only about 60% of treated patients experience a significant improvement in disease symptoms. Numerous clinical and rodent studies have identified the purinergic P2X7 receptor (P2X7R) as one of the genetic factors potentially contributing to the disease risk. In this respect, genetically engineered mouse models targeting the P2X7R have become increasingly important in studying designated immunological features and subtypes of depression in vivo. This review provides an overview of the P2X7R -related mouse lines currently available for translational psychiatric research and discusses their strengths, weaknesses, and potentials.

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The effects of P2X7 receptor knockout on emotional conditions over the lifespan of mice

Cited by 8 publications

References 23 publications

Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge

Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge

Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties

P2X7 Receptor-Related Genetic Mouse Models – Tools for Translational Research in Psychiatry

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