The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: an in Vitro Study

Abstract

Amaç: Bronkospazm postoperastif ve intraoperatif dönem boyunca karşılaşılabilen çok önemli bir komplikasyondur. Bu komplikasyon cerrahi, anestezi ve hastaya ait nedenlerle oluşabilmektedir. Postoperatif analjezi oluşturmak için intraoperatif dönemde rutinde pek çok analjezik tercih edilmektedir. Bizde bu çalışmada invitro şartlarda bir bronkospazm modeli olarak supramaksimal tonuslü rat trakeasında intravenöz analjeziklerden ibuprofen ve parasetamolün etkilerini görmeyi amaçladık. Objective: Bronchospasm is a very important complication that can be encountered during the postoperative and intraoperative periods. This complication may be caused by surgery, anesthesia, or patient-related issues. Many analgesics are preferred during the intraoperative period for postoperative analgesia. In this study, we aimed to investigate the effects of ibuprofen and paracetamol on rat bronchus with supramaximal tonus as a model of bronchospasm under in vitro conditions. Materials and Methods: Totally, 20 male rats were used in our study. After the ketamine anesthesia, the left main bronchus of each rat was removed and suspended in the organ bath in Krebs solution. Four rat bronchi were excluded because of not demonstrating viability with atropine and acetylcholine. After demonstrating the viability of the rats' bronchi (n=16), acetylcholine was applied to produce supramaximal contraction. The rats' bronchi with supramaximal contraction were randomly divided into two groups. Paracetamol was applied to Group 1, and ibuprofen to Group 2. The contraction responses of each group were recorded and compared statistically. Results: While a statistical significance was not detected regarding the supramaximal contraction in Group 1 with a mean of 0.18±0.07% (p>0.05), tonus was reduced to 6.79±0.28% (p<0.05) in Group 2, and the relaxation response reached the baseline tonus in this group. Conclusion: Intraoperative analgesia is very important in preventing postoperative complications and ensuring patient comfort. In general, opioids and concomitant NSAI or paracetamol group drugs are preferred intraoperatively for postoperative analgesia. In our study, although there was no effect of paracetamol on rat bronchi with supramaximal tonus, ibuprofen showed an unexpected significant relaxation response. In conclusion, ibuprofen may be preferred much more the than paracetamol in patients with high risk of clinical bronchospasm.