The effects of partial hypophysectomy in the rabbit

Campbell, H. J.

doi:10.1113/jphysiol.1959.sp006346

Cited by 10 publications

(2 citation statements)

References 21 publications

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“…These findings indicate that more than 75% of the adenohypophysis is required to maintain normal testicular weight. When compared with the results of Campbell (1959) in the rabbit, it can be said that this value is much higher than in mammals.…”

Section: Resultsmentioning

confidence: 83%

“…Mitchell (1929) stated that partial hypophysectomy did not cause death in the fowl and reported the effects on gonads, adrenals, and parathyroids. Campbell (1959) observed the effects of graded partial adenohypophysectomy on body weight, ovary, adrenal, and thyroid in the rabbit and stated mat partial hypophysectomy had no significant effect on body weight and much more of the remnant was needed to maintain the organs in normal histological appearance than in terms of weight.…”

Section: Introductionmentioning

confidence: 97%

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Histological Changes in the Testis of the Domestic Fowl After Partial Adenohypophysectomy

Tanaka

Fujioka

1981

Poultry Science

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The effects of partial adenohypophysectomy on comb size, testicular weight, and histology 20 or 30 days after the operation are described and discussed in relating these observed changes with the volume of remaining adenohypophyseal tissue. From the present observation, it is concluded that 1) the response of the domestic fowl to partial deficiency of adenohypophyseal tissue may be more sensitive than that of some mammals, 2) the decrease in testicular weight and tubular diameter precedes the histological change in testis and comb regression, and 3) to maintain fully active testicular function, more than 75% of the adenohypophysis is needed. About 40% of the adenohypophyseal tissue including a remnant of cephalic lobe can stimulate spermatogenesis, but the spermatozoa produced were partially abnormal. The critical amount of adenohypophyseal tissue for normal spermiogenesis may exist between 55 and 75%. All histological change is initially observed in the center of testis and then extended toward the periphery. It is suggested that the cephalic lobe contains at least a trace of ICSH in addition to FSH.

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Section: Resultsmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 97%