The effects of pentoxifylline and tocopherol in jaw osteomyelitis

Seo, Mi Hyun; Eo, Mi Young; Myoung, Hoon; Kim, Soung Min; Lee, Jong Ho

doi:10.5125/jkaoms.2020.46.1.19

Cited by 30 publications

(24 citation statements)

References 22 publications

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“…Depending on its location and extent, symptoms may include pain, bad breath, dysgeusia, numbness, trismus, mastication and speech difficulties, fistula, pathologic fractures, and local, spreading, or systemic infection. Osteoradionecrosis is a lifelong risk for those who have received high-dose radiation [16].…”

Section: Osteoradionecrosismentioning

confidence: 99%

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Late side effects of radiation treatment for head and neck cancer

Brook

2020

Radiat Oncol J

169

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Radiation therapy (RT) is often used to treat head and neck cancer (HNC) [1]. RT can damage blood vessels that nourish muscles, nerves, and bones resulting in a progressive "radiation fibrosis syndrome", which causes a variety of complications [2]. The likelihood and severity of complications depends on a number of factors, including the total dose of radiation delivered, over what time it was delivered and what parts of the head and neck received radiation. The side effects of RT for HNC are divided into early (acute) and long-term (chronic) effects [3]. Early side effects occur during the course of therapy and during the immediate post therapy period (approximately 2-3 weeks after the completion of a course of RT). Late effects can manifest any time thereafter, from weeks to years later [4]. Patients are usually most bothered by the early effects of RT, although these will generally resolve over time. Knowledge of the ra-Patients undergoing radiation therapy for head and neck cancer (HNC) experience significant early and long-term side effects. The likelihood and severity of complications depends on a number of factors, including the total dose of radiation delivered, over what time it was delivered and what parts of the head and neck received radiation. Late side effects include: permanent loss of saliva; osteoradionecrosis; radiation recall myositis, pharyngoesophageal stenosis; dental caries; oral cavity necrosis; fibrosis; impaired wound healing; skin changes and skin cancer; lymphedema; hypothyroidism, hyperparathyroidism, lightheadedness, dizziness and headaches; secondary cancer; and eye, ear, neurological and neck structures damage. Patients who undergo radiotherapy for nasopharyngeal carcinoma tend to suffer from chronic sinusitis. These side effects present difficult challenges to the patients and their caregivers and require lifelong strategies to alleviate their deleterious effect on basic life functions and on the quality of life. This review presents these side effects and their management.

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Section: Osteoradionecrosismentioning

confidence: 99%

“…Tooth extraction and dental disease in irradiated areas are major contributors to osteoradionecrosis. It may be necessary to remove decayed teeth before RT if they are in the area receiving RT [16]. Ideally, at least 7 to 14 days should be allowed for healing before initiation of RT; some have suggested allowing up to 21 days.…”

Section: Osteoradionecrosismentioning

confidence: 99%

Late side effects of radiation treatment for head and neck cancer

Brook

2020

Radiat Oncol J

169

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“…Each patient's singular and clinical specifications must be considered in order to optimize the benefits of treatment. Currently, newly updated paradigms for conservative treatment such as medication with pentoxifylline and tocopherol are being clinically accepted 2 .…”

mentioning

confidence: 99%

Essential review points on the retrospective study of osteoradionecrosis in the jaws

Seo

Kim

2020

JKAOMS

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Recently, after reviewing the online journal, Journal of the Korean Association of Oral and Maxillofacial Surgeons, we found a recently published original article by Manzano et al., entitled, "Retrospective study of osteoradionecrosis in the jaws of patients with head and neck cancer". Although this original article was well written and provided a great deal of information regarding osteoradionecrosis in the jaws, we would like to add a few additional recommendations based on our small concerns and recently updated articles.

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“…The use of PENTO seems to be a promising alternative, but all systematic reviews and meta-analysis show the need for further prospective clinical trials using PENTO in the treatment of ORN; therefore, the evidence remains insufficient to determine its treatment protocol for ORN 3 . The study cited by the authors used PENTO as a treatment for diseases with different etiopathogenesis as ORN and osteonecrosis of the jaws related to medications 4 . We do not understand how it is not possible to analyze the results of PENTO treatment of bone necrosis of different diseases included in the same group.…”

mentioning

confidence: 99%

“…Two relevant points after a careful reading of the brief communication are that the article by these authors who used PENTO as a conservative treatment showed a serious error when they included bone necrosis of different etiopathogenesis in the same group 4 . Treatment with PENTO is one of the conservative treatment options as implicit in our study.…”

mentioning

confidence: 99%