The effects of percutaneous transluminal coronary intervention on biomarkers of oxidative stress in the erythrocytes of elderly male patients

Szewczyk-Golec, Karolina; Grzelakowski, Paweł; Ługowski, Tomasz; Kędziora, J

doi:10.1080/13510002.2016.1257754

Cited by 5 publications

(3 citation statements)

References 54 publications

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“…Curcumin supplementation 45mg/ day for 14 days greatly reduced ischemia-reperfusion injury in children undergoing Tetralogy of Fallot surgery. (30,31) Meanwhile, current study had less significant antioxidant effect due to lower period of treatment.…”

Section: Discussionmentioning

confidence: 74%

Curcumin’s Antioxidant Properties in Stable Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention: A Randomized Controlled Trial

et al. 2022

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BACKGROUND: Percutaneous coronary intervention (PCI) is the most common intervention for coronary artery disease (CAD) with very low complications. High oxidative stress post-PCI is associated with further atherosclerosis progression. Curcumin, extracted from a specific type of herbs, exhibits anti-oxidant properties by acting as hydrogen and electron donor for superoxide radicals. The aim of this study is to determine the effect of curcumin’s antioxidant properties in reducing oxidative stress of post-PCI in stable CAD.METHODS: This study was a double-blind parallel randomized controlled trial among 50 stable CAD patients undergoing PCI in Cipto Mangunkusumo General Hospital and Jakarta Heart Center. The subjects received either 45 mg/day curcumin or placebo 7 days pre-PCI until 48 hours post-PCI. Reduced oxidative stress markers (decreased MDA or increased GSH) were measured in 3 phases (7 days pre-PCI, 24 hours post-PCI, 48 hours post-PCI).RESULTS: Curcumin group showed increased MDA from baseline to 24 hours (Δ1=0.01 vs. 0.03; p=0.3) and decreased MDA from baseline to 48 hours (Δ2=-0.06 vs. 0.03; p=0.9). While, curcumin group showed decreased GSH from baseline to 24 hours (Δ1=-49.7% vs. 12.2%; p=0.4) and from baseline to 48 hours (Δ2=-19.09% vs. 11.4%; p=0.6). However, no significant changes were found in malondialdehide (MDA) and glutathione (GSH) level after the intervention.CONCLUSION: The 45 mg/day curcumin supplementation from 7 days pre-PCI until 48 hours post-PCI had no significant antioxidant effect in stable CAD post-PCI.KEYWORDS: coronary artery disease, curcumin, antioxidant, percutaneous coronary intervention

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Section: Discussionmentioning

confidence: 74%

Curcumin’s Antioxidant Properties in Stable Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention: A Randomized Controlled Trial

et al. 2022

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“…In the setting of CA and PCI, oxidative stress emerges as a dangerous and often underestimated parameter for CIN provocation, while in clinical studies the first attempts of antioxidant supplementation prior or after CA did not present the expected results in CIN amelioration ( 7 , 20 ). Few studies have examined the changing environment regarding oxidative stress following CA and related interventions ( 21 , 22 ), where femoral assess was used. In the era of growing use of radial assess in CA, a changing post-procedural oxidative profile compared to femoral assess was assumed.…”

Section: Discussionmentioning

confidence: 99%

“…In the study of Kochiadakis et al total peroxides significantly increased 1 day post-stent implantation only in patients receiving bare-metal stents compared to patients receiving sirolimus-eluting stents ( 21 ) and the increase in total peroxide correlated with in-stent late lumen loss. In elderly patients with stable angina submitted to CA and PCI via the femoral route, Szewczyk-Golec et al found no differences in antioxidant enzymes and malondialdehyde levels ( 22 ). However, Ciçek et al reported significant increases in TAC immediately after PCI via the femoral route ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and kidney injury in trans-radial catheterization

Tsarouhas

Tsitsimpikou²,

Papantoni

et al. 2018

biom rep

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Oxidative stress is linked to coronary artery disease and is a major mechanism in contrast-induced nephropathy. Trans-radial approach in coronary angiography (CA) with minimized peri-procedural bleeding is expected to reduce acute kidney injury incidence. In the present study, oxidative stress patterns observed in radial CA and their associations with early manifestations of kidney injury are described. A total of 20 stable coronary disease patients submitted to CA and 17 sex-matched patients undergoing computed tomography for myoskeletal reasons were enrolled. Reduced glutathione, catalase, thiobarbituric acid reactive species (TBARS) levels and total anti-oxidant status were measured at various time points postangiography. In ischemic patients baseline TBARS levels were 2-fold lower compared to controls, while carbonyls levels were 35% higher. Glutathione was almost 4-fold lower than the control group. Glutathione and lipid peroxidation in ischemic patients gradually increased after contrast medium administration and reached 180% (P<0.001) and 20% (P=0.021) after 4–6 h, respectively. Four patients presented early evidence of contrast-induced nephropathy postangiography, while no control patient developed acute kidney injury. In the multiple logistic regression analysis, only the creatinine levels at baseline influenced the frequency of early contrast-induced nephropathy development (β =0.36, 95% CI: 0.285–0.438, P=0.01). Glutathione low levels were dominant in the baseline values of ischemic patients who developed contrast-induced nephropathy. Glutathione levels rapidly increased while protein oxidation decreased at the expense of lipid peroxidation. In conclusion, early oxidative stress changes occur in trans-radial CA patients with a mild profile, sufficient to mobilize patient antioxidant defenses.

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Role of Brain-Derived Neurotrophic Factor in Anxiety or Depression After Percutaneous Coronary Intervention

Ning,

Ge,

et al. 2023

Mol Neurobiol

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The effects of percutaneous transluminal coronary intervention on biomarkers of oxidative stress in the erythrocytes of elderly male patients

Abstract: The results confirm that an advanced state of atherosclerosis is related to greater levels of oxidative stress. The study indicates that both procedures may induce antioxidant defenses; however, PTCA exclusively induces a long-term reduction in lipid peroxidation.

Cited by 5 publications

References 54 publications

Curcumin’s Antioxidant Properties in Stable Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention: A Randomized Controlled Trial

Curcumin’s Antioxidant Properties in Stable Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention: A Randomized Controlled Trial

Oxidative stress and kidney injury in trans-radial catheterization

Role of Brain-Derived Neurotrophic Factor in Anxiety or Depression After Percutaneous Coronary Intervention

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