The Effects of Perioperative Portal Venous Inoculation With Donor Lymphocytes on Renal Allograft Survival in the Rat

Yoshimura, Norio; Matsui, Shinji; Hamashima, T; Lee, Chol Joo; Ohsaka, Yasuhito; Oka, Takahiro

doi:10.1097/00007890-199001000-00037

Cited by 48 publications

(19 citation statements)

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“…For example, the granulocytes released from the liver graft might influence the circulatory instability observed after liver transplantation which is associated with high levels of neutrophil and macrophage activation [27]. In addition, it is well known that injection of donor lymphocytes [17,32] and the release of donor lymphocytes from the graft [lo] can enhance graft survival in experimental animal models. Further studies should analyze the role of the longer persistence of donor B cells in the host blood compared to donor Tcells, as indicated by the decline of the T/B-cell ratio.…”

Section: Discussionmentioning

confidence: 99%

Rapid exchange of large numbers of donor- and host leukocytes after human liver transplantation

Heerwagen¹,

Schuster²,

Bornscheurer³

et al. 2001

Transplant International

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After liver transplantation, the release of donor leukocytes into the host and the uptake of host leukocytes by the graft is one of the earliest immunologic interactions between donor and host. Using three-color flow cytometry, these interactions were investigated in eight patients from 5 min-24 h after receiving HLA unmatched liver grafts. Five minutes after reperfusion, 5.0 YO * 1.4 YO of all blood leukocytes in the host were of donor origin, decreasing to 1.1 % 0.8% after 24 h. Donor granulocytes preferentially disappeared from the host circulation, whereas no differences were found between NK-cells and various B-and T cell subpopulations. Furthermore, host granulocytes were preferentially retained in the donor liver. Thus, despite extensive pre-operative perfusion, more than lo9 donor leukocytes quickly leave the liver graft while host granulocytes preferentially accumulate there. A better understanding of the molecular mechanisms mediating these early interactions might help to develop new strategies for diagnosis and therapy of liver graft rejection.

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Section: Discussionmentioning

confidence: 99%

Rapid exchange of large numbers of donor- and host leukocytes after human liver transplantation

Heerwagen¹,

Schuster²,

Bornscheurer³

et al. 2001

Transplant International

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“…results in specific and systemic immune tolerance [19,20], preimmunization via the p.v. has been utilized for inducing donor-specific tolerance across MHC barriers and preventing the rejection of allografts such as the heart [3,4], kidney [6] and pancreas [5]. Although, in these studies, the survival rate of the allografts was indeed prolonged, all except for the liver allograft [7], which itself can induce donor-specific tolerance [21], were finally rejected.…”

Section: Discussionmentioning

confidence: 99%

“…Portal venous (p.v.) administration of foreign cells has been reported to induce donor-specific tolerance across major [1][2][3][4][5][6][7], minor [8], and xeno [9] histocompatibility complex barriers. We have previously found that a more significant number of allogeneic bone marrow cells (BMCs) are retained in the livers or spleens of recipients after p.v.…”

Section: Introductionmentioning

confidence: 99%

A New Method for Tolerance Induction: Busulfan Administration Followed by Intravenous Injection of Neuraminidase‐Treated Donor Bone Marrow

et al. 2001

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“…30 It has been reported that portal venous preimmunization of foreign cells has induced alloantigen-specific unresponsiveness. [31][32][33][34] It is also known that microchimerism after allograft transplantation is often associated with tolerance without immunosuppression, especially after liver transplantation. 35 Taken together, we propose a hypothesis that may explain the induction of maternal tolerance against the fetus during pregnancy.…”

Section: Fetal Microchimerism and The Livermentioning

confidence: 99%

Fetal microchimerisms in the mother: Immunologic implications

et al. 2000

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The previously held concept that the fetus is completely separated from the mother, especially by trophoblasts that line the outer layer of the placenta, has recently been questioned. It has recently been shown that fetal cells are detectable not only in the peripheral blood, but also in maternal skin and liver. Although the migration of fetal cells into the maternal circulation has been given a great deal of attention because of its implication in the prenatal diagnosis of genetic diseases, the potential role of such placental transfer of fetal cells in the pathogenesis of autoimmune diseases has only recently been considered. In patients with scleroderma, fetal cell-derived DNA was detected more frequently in the peripheral blood of patients than controls. This finding of a limited number of fetal cells in maternal tissues leading to microchimerism has been proposed to have a role in the induction of scleroderma. Although evidence for microchimerism has also been confirmed in a high frequency of liver tissues from patients with primary biliary cirrhosis (PBC), a similar high frequency was noted in control patients, which suggests that microchimerism by itself is unlikely to fully account for the pathogenesis of PBC. The finding of such a high frequency of fetal microchimerism in the liver suggests that this is a very common event, raising the possibility that the migration of fetal cells may be important in the induction and subsequent maintenance of tolerance against the fetus during pregnancy. In addition, it is clearly possible that such microchimerism could contribute to the pathogenesis of select autoimmune diseases. Copyright 2000 by the American Association for the Study of Liver DiseasesA lthough the fetus in the uterus is sequestered from the mother by the placenta, this is not a mechanically complete barrier. Several examples show that fetal cells migrating into the maternal body can be found in such tissues as blood and skin. Fetal-derived DNA can be detected in maternal peripheral blood at early stages of gestation and persist long after pregnancy. Recently, our laboratory has also shown that fetal cell-derived genes are detectable in maternal liver tissue, in some cases as long as 43 years after pregnancy. Whether this microchimerism, i.e., migration and presence of fetal cells within maternal tissues, has an important role in either physiological or immunologic function is unclear, but the very high detection rate of fetal-derived DNA in the mother provides suggestive evidence that microchimerism may not be an uninvolved bystander. We review recent studies showing microchimerism in the mother and address its putative role in autoimmunity and the maintenance of tolerance against the fetus.

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The Effects of Perioperative Portal Venous Inoculation With Donor Lymphocytes on Renal Allograft Survival in the Rat

Cited by 48 publications

References 0 publications

Rapid exchange of large numbers of donor- and host leukocytes after human liver transplantation

Rapid exchange of large numbers of donor- and host leukocytes after human liver transplantation

A New Method for Tolerance Induction: Busulfan Administration Followed by Intravenous Injection of Neuraminidase‐Treated Donor Bone Marrow

Fetal microchimerisms in the mother: Immunologic implications

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