The effects of Persian shallot extract on the levels of some blood biochemical parameters in streptozotocin-induced diabetic rats

Hosseini-Zijoud, Seyed-Mostafa; Javad, Hosseini; Mahmoodi, Mehdi; Hassanshahi, Gholamhossein; Hashemi, Behrooz; Seyed-Mohammad, Hosseini-Zijoud

doi:10.5897/ajar11.2498

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Persian shallot (Allium hirtifolium Boiss) is a nutritive plant with special taste that belongs to liliacea family. Biochemical analysis of Persian shallot extracts has confirmed its hypoglycemic and hepatoprotective effects [17,18]. The Persian shallot extract is a stronger hypoglycemic agent compared to garlic extract and it could be a useful supplemental remedy in diabetes [19].…”

Section: Introductionmentioning

confidence: 99%

Persian Shallot (<i>Allium hirtifolium</i> Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Mahmoodi¹,

Zarei²,

Rezaeian³

et al. 2013

AJPS

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Hepatic GCK is a key enzyme in glucose homeostasis and, as such, is a potential target for treatment strategies of diabetes. We investigated the effect of Persian shallot (Allium hirtifolium Boiss) hydroalchoholic extract on blood glucose level, plasma insulin level, GCK activity and its gene expression. Thirty two male rats were divided into 4 groups of 8, diabetic groups received 100 and 200 mg/kg Persian shallot extract, diabetic control and normal control received 0.9% saline for 30 days. Investigations of gene expression by Real-Time PCR showed that Persian shallot had led to gently increased GCK gene expression in diabetic rats. GCK activity increased significantly in Persian shallot treated group in dose dependent manner (P < 0.05). These results indicated that Persian shallot exhibited a significant potential as a hypoglycemic agent perhaps via its ability to enhance insulin secretion, GCK gene expression and its activity.

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Section: Introductionmentioning

confidence: 99%

Persian Shallot (<i>Allium hirtifolium</i> Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Mahmoodi¹,

Zarei²,

Rezaeian³

et al. 2013

AJPS

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Effects of Fullerene C60 and Fruit Extract of Balanites aegyptiaca Plant on the Nephrotoxicity and Hematotoxicity Induced by Doxorubicin in Diabetic Male Albino Rats.

EL-Shater

Salman

Kasem

et al. 2018

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Effect of Persian shallot (Allium hirtifolium Boiss.) extract on glucokinase (GCK), glycogen phosphorylase and phosphoenolpyruvate carboxykinase (PEPCK) genes expression in diabetic rats

Mahmoodi¹

2013

Afr. J. Pharm. Pharmacol.

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There has been a growing interest in hypoglycaemic agents from natural products, especially those derived from plants. In the current survey, hypoglycaemic properties of Persian shallot (Allium hirtifolium Boiss) was evaluated by studying mRNA expression levels of the key enzymes involved in carbohydrate metabolism in liver, Glucokinase (GCK), phosphoenolpyruvate carboxykinase (PEPCK), and glycogen phosphorylase. Thirty two male rats were divided into 4 groups of 8, diabetic groups received 100 and 200 mg/kg Persian shallot extract, diabetic control and normal control received 0.9% saline for 30 days. At the end of the experimental period blood and liver samples were collected. FBS and insulin levels were measured and followed by analysis of the gene expression by Real-Time PCR based methods. Findings indicated that the Persian shallot significantly reduces the FBS level in parallel with slight enhancement of insulin in diabetic rats' serum. Investigations of gene expression showed that Persian shallot gently increased GCK and glycogen phosphorylase but decreased PEPCK gene activity, in diabetic rats. In conclusion, the data suggest that Persian shallot is an effective hypoglycaemic agent, the observed effect may be via its ability to enhance insulin secretion and GCK gene expression and to decrease hepatic glucose output by reducing PEPCK.

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The effects of Persian shallot extract on the levels of some blood biochemical parameters in streptozotocin-induced diabetic rats

Cited by 3 publications

References 23 publications

Persian Shallot (<i>Allium hirtifolium</i> Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Persian Shallot (<i>Allium hirtifolium</i> Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Effects of Fullerene C60 and Fruit Extract of Balanites aegyptiaca Plant on the Nephrotoxicity and Hematotoxicity Induced by Doxorubicin in Diabetic Male Albino Rats.

Effect of Persian shallot (Allium hirtifolium Boiss.) extract on glucokinase (GCK), glycogen phosphorylase and phosphoenolpyruvate carboxykinase (PEPCK) genes expression in diabetic rats

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The effects of Persian shallot extract on the levels of some blood biochemical parameters in streptozotocin-induced diabetic rats

Cited by 3 publications

References 23 publications

Persian Shallot (&lt;i&gt;Allium hirtifolium&lt;/i&gt; Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Persian Shallot (&lt;i&gt;Allium hirtifolium&lt;/i&gt; Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Effects of Fullerene C60 and Fruit Extract of Balanites aegyptiaca Plant on the Nephrotoxicity and Hematotoxicity Induced by Doxorubicin in Diabetic Male Albino Rats.

Effect of Persian shallot (Allium hirtifolium Boiss.) extract on glucokinase (GCK), glycogen phosphorylase and phosphoenolpyruvate carboxykinase (PEPCK) genes expression in diabetic rats

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Persian Shallot (<i>Allium hirtifolium</i> Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

Persian Shallot (<i>Allium hirtifolium</i> Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats