The effects of pH on fluoxetine in Japanese medaka (Oryzias latipes): Acute toxicity in fish larvae and bioaccumulation in juvenile fish

Nakamura, Yuki; Yamamoto, Hiroshi; Sekizawa, Jun; Kondo, Takuya; Hirai, Nishio; Tatarazako, Norihisa

doi:10.1016/j.chemosphere.2007.06.089

Cited by 226 publications

(158 citation statements)

References 23 publications

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“…For example, uptake and elimination of ionizable pharmaceuticals (over 70% of drugs are ionizable) by fish [12,13] and invertebrates [14] are modified by surface water pH [13,[15][16][17]. Unfortunately, environmental modelling approaches for predicting fate, transport, exposure and bioaccumulation, which were designed to address historical contaminants (e.g.…”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream

Haddad

Luek

et al. 2014

Phil. Trans. R. Soc. B

133

118

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Though pharmaceuticals are increasingly observed in a variety of organisms from coastal and inland aquatic systems, trophic transfer of pharmaceuticals in aquatic food webs have not been reported. In this study, bioaccumulation of select pharmaceuticals was investigated in a lower order effluent-dependent stream in central Texas, USA, using isotope dilution liquid chromatography–tandem mass spectrometry (MS). A fish plasma model, initially developed from laboratory studies, was tested to examine observed versus predicted internal dose of select pharmaceuticals. Pharmaceuticals accumulated to higher concentrations in invertebrates relative to fish; elevated concentrations of the antidepressant sertraline and its primary metabolite desmethylsertraline were observed in the Asian clam, Corbicula fluminea , and two unionid mussel species. Trophic positions were determined from stable isotopes (δ 15 N and δ 13 C) collected by isotope ratio-MS; a Bayesian mixing model was then used to estimate diet contributions towards top fish predators. Because diphenhydramine and carbamazepine were the only target compounds detected in all species examined, trophic magnification factors (TMFs) were derived to evaluate potential trophic transfer of both compounds. TMFs for diphenhydramine (0.38) and carbamazepine (1.17) indicated neither compound experienced trophic magnification, which suggests that inhalational and not dietary exposure represented the primary route of uptake by fish in this effluent-dependent stream.

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Section: Introductionmentioning

confidence: 99%

Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream

Haddad

Luek

et al. 2014

Phil. Trans. R. Soc. B

133

118

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“…8 On the basis of these results which showed quick accumulation for fish and snail, we assumed that steady state could also be reached in V. piscinalis after 7 days of exposure and we compared fluoxetine body burden in the two species on day 7. Concentrations of fluoxetine and estimate BCF tot in P. antipodarum were significantly higher (P<0.05) than in V. piscinalis (Tables 1 and 2), 3,8,9,14 implying a higher bioaccumulation of the parent compound in P. antipodarumafter 7 days of exposure. Exposure systems were rigorously similar for both species.…”

Section: Resultsmentioning

confidence: 89%

“…On days 7 and 14, 3 P. antipodarum were collected per condition for fluoxetine and norfluoxetine analysis and 3 V. piscinalis on day 7. Due to the lipophilic nature of fluoxetine, 8,9 triacylglycerol (TG) content of snails was measured, 10 as proxy of total lipid content, TG being the principal lipid class in mollusks. 11 Fluoxetine was measured in water on days 7 and 14 as published elsewhere, 10 as well as fluoxetine and norfluoxetine in snails.…”

Section: Methodsmentioning

confidence: 99%

“…In these conditions, the limit of quantification for fluoxetine and norfluoxetine in snail samples was respectively 7.7 and 3.8 ng/g. Fluoxetine accumulation on days 7 and 14, was assessed by calculating bioaccumulation factor (BCF) estimates according to Nakamura et al 9 The estimate (BCF tot BCF tot = C snail / C water ) was calculated, using the fluoxetine concentrations measured in snails after 7 and 14 days (C snail ) for P. antipodarum and 7 days for V. piscinalis.…”

Section: Methodsmentioning

confidence: 99%

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Fluoxetine accumulation and metabolism as exposure biomarker to better understand biological effects in gastropods

Gust¹,

Cren-Olivé²,

Buleté³

et al. 2013

J Xenobiotics

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“…Chapman et al 1998), but pH may also be important for the same processes concerning organic substances. Nakamura et al (2008) recently showed that acute toxicity and bioconcentration of the pharmaceutical fluoxetine was affected by pH in the Japanese medaka (Oryzias latipes). Toxicity increased with increasing pH and bioconcentration was lower at pH 7 and higher at pH 9, likely because of increase in nonionized forms with significantly higher hydrophobicity than the ionized forms at pH values closer to pKa.…”

Section: Environmental Factors Of Importance For Uptake and Effectsmentioning

confidence: 99%

Improving the Value of Standard Toxicity Test Data in REACH

Breitholtz

Lundström

Dahl

et al. 2010

Regulating Chemical Risks

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Worldwide, environmental risk assessment strategies are based on the assumption that measuring direct effects of single substances, using a few single species tests, in combination with safety factors correcting for extrapolation inconsistencies, can be used to protect higher levels of biological organization, such as populations and even ecosystems. At the same time, we are currently facing a range of pollution problems (Millennium Ecosystem Assessment Series 2005), of which some could at least indirectly be linked to the fact that this assumption may not be fully valid. Consequently, there is an ongoing scientific debate on whether current chemical control protocols are sufficient for protection of ecosystems, and numerous suggestions for improvements have been presented by the scientific community, e.g. alternative tests and testing strategies. On the other hand, few of these suggestions actually reach the regulatory world (or become implemented), and risk assessment today basically follows the same paradigm as 30 years ago. While the new REACH regime is exceptionally ambitious, this chapter observes several problems and gaps in this regulatory framework. We suggest measures and approaches which imply increased ecological realism and understanding in future regulatory work.

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The effects of pH on fluoxetine in Japanese medaka (Oryzias latipes): Acute toxicity in fish larvae and bioaccumulation in juvenile fish

Cited by 226 publications

References 23 publications

Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream

Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream

Fluoxetine accumulation and metabolism as exposure biomarker to better understand biological effects in gastropods

Improving the Value of Standard Toxicity Test Data in REACH

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