The Effects of Phellodendron Decoction on Wound Healing of Anal Fistula after Anal Fistulotomy

Deng, Heng; Zhang, Jun; Yuan, Xiancang

doi:10.1155/2022/7363006

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…Perianal pain on day 1, 2, and 3 after surgery was evaluated by numerical scoring [ 20 ]. Length of stay (days) was recorded from the first day of hospitalization to discharge.…”

Section: Methodsmentioning

confidence: 99%

Internal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease

Fang,

Deng,

2023

Med Sci Monit

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Background The high recurrence rate of perianal fistula Crohn’s disease (PFCD) increases the need to protect the anal sphincter during each surgical treatment of fistulas. We aimed to evaluate the safety and efficacy of internal orifice alloy closure in patients with PFCD. Material/Methods Fifteen patients with PFCD were enrolled in the study between July 6, 2021, and April 27, 2023. All patients underwent preoperative colonoscopy and anal magnetic resonance examination for diagnosis and evaluation. Internal orifice alloy closure (IOAC) was performed only when Crohn’s disease was in remission. The external sphincter had not been severed. Perianal magnetic resonance imaging examination was used for postoperative evaluation after 6 months. Fistula cure rate, length of stay, perianal pain, and Wexner incontinence score were retrospectively compared between 15 patients treated with IOAC and 40 patients treated with other surgical methods. Results Fifteen patients (male/female: 9/6, age: 23.6±14.3 years) with PFCD were included (follow-up: 24 months). In total, 20.0% (3) had multiple tracts, and 13.3% (2) had a high anal fistula. Among them, 10 patients received biologics for induction for mucosal healing before surgery. The fistula healed completely in 80.0% (12/15) and did not heal in 20.0% (3/15). Three patients who did not heal underwent fistulotomy and eventually recovered. IOAC is not superior in terms of fistula healing rates, length of stay, and anal pain, but its Wexner incontinence scores are significantly lower than with other surgical methods. Conclusions IOAC is a novel sphincter-saving surgery that is effective and safe for the treatment of PFCD.

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“…Perianal pain on day 1, 2, and 3 after surgery was evaluated by numerical scoring [ 20 ]. Length of stay (days) was recorded from the first day of hospitalization to discharge.…”

Section: Methodsmentioning

confidence: 99%

Internal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease

Fang,

Deng,

2023

Med Sci Monit

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“…The anal fistula is the duct between the perianal skin and the rectoanal canal, resulting from chronic infection and epithelialization of the drainage duct ( 6 ). Its pathological elements include the primary internal orifice, fistula, and secondary external orifice ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the mechanical properties and clinical application of nickel–titanium shape memory alloy anal fistula clip

Deng,

Li,

Fang

et al. 2023

Front. Surg.

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ObjectiveThe study investigates the mechanical properties of a nickel–titanium shape memory alloy anal fistula clip (NiTi-AFC), studies the surgical method of treating anal fistula, and evaluates its clinical efficacy.MethodsThe anal fistula clip was formed in nickel–titanium alloy with a titanium content of 50.0%–51.8%. The mechanical properties and chemical properties were tested. A total of 31 patients with anal fistula were enrolled between 1 January 2020 and 1 January 2023. All patients underwent internal orifice closure surgery using NiTi-AFC, and anorectal magnetic resonance or ultrasound was performed before surgery and 6 months after surgery for diagnosis and evaluation. Fistula cure rates, length of stay, perianal pain, and Wexner incontinence scores were retrospectively compared between patients treated with NiTi-AFC and patients treated with other surgical methods.ResultNiTi-AFC has a density of 6.44–6.50 g·cm−3, with a shape-restoring force of 63.8 N. The corrosion rate of NiTi-AFC in 0.05% hydrochloric acid solution at atmospheric pressure and 20°C is approximately 6.8 × 10−5 g·(m·h)−1. A total of 31 patients (male/female: 19/12, age: 43.7 ± 17.8 years) were included. Among them, 22.6% (7) had multiple anal fistula, 16.1% (5) had high anal fistula, and 48.3% (15) had perianal fistula Crohn's disease. In total, 12.9% (4/31) did not achieve primary healing, underwent fistula resection, and eventually recovered. A retrospective analysis showed that the fistula healing rate, length of stay, and anal pain of NiTi-AFC treatment were similar to those of other traditional surgeries, but the Wexner incontinence score was significantly lower.ConclusionNiTi-AFC has shape memory properties, corrosion resistance, superelastic effect, and surface cell adhesion. It is applied to internal orifice closure surgery of anal fistula, with good therapeutic effect, and can protect the anal function.

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“…[1] Delayed healing and other complications may occur in some patients, reducing the quality of life. [2,3] The healing status after anal fistula surgery is related to many factors, and the surgical method is only 1 aspect that affects the healing rate and recurrence rate after anal fistula surgery. [4] The nutritional status of patients and the local microenvironment of wounds are also important factors affecting healing, such as systemic hyperglycemia in diabetes patients and local inflammation of Crohn's anal fistula.…”

Section: Introductionmentioning

confidence: 99%

The efficacy and safety of Chinese herbal medicine for reducing wound complications after anal fistula surgery: A protocol for systematic review and meta-analysis

Qi¹,

Wang²,

Xu³

et al. 2022

Medicine

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Background: Anal fistula is one of the most common diseases in anorectal surgery. The wound healing after surgery can affect the prognosis of patients. We conducted a protocol for systematic review and meta-analysis to assess the efficacy and safety of Chinese herbal medicine for reducing wound complications after anal fistula surgery. Methods: We have prepared this protocol in accordance with the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA-P) statement. We will search the following databases: the China National Knowledge Infrastructure, Wanfang Database, Chinese Science and Technology Periodical Database, Chinese Biomedical Literature Database, Pubmed, Embase, Web of Science, and the Cochrane library. Two authors will independently assess the risk of bias of the included studies based on the bias risk assessment tool recommended in the Cochrane “Risk of bias” assessment tool. All calculations are carried out with STATA13.0 software. Results: A synthesis of current evidence of Chinese herbal medicine for wound management after anal fistula surgery will be shown in this protocol. Conclusion: This study may provide more convincing evidence to help clinicians make decisions when dealing with anal fistula patients after surgery.

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The Effects of Phellodendron Decoction on Wound Healing of Anal Fistula after Anal Fistulotomy

Cited by 6 publications

References 25 publications

Internal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease

Internal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease

Evaluation of the mechanical properties and clinical application of nickel–titanium shape memory alloy anal fistula clip

The efficacy and safety of Chinese herbal medicine for reducing wound complications after anal fistula surgery: A protocol for systematic review and meta-analysis

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