The effects of phytochemicals on serum triglycerides in subjects with hypertriglyceridemia: A systematic review of randomized controlled trials

Abstract

This systematic review aimed to evaluate the efficacy of phytochemicals on lipid parameters in patients with hypertriglyceridemia (HTG). A comprehensive search was performed in PubMed/Medline, Scopus, ISI Web of Science, and Google Scholar from inception up to October 2021 to recognize randomized controlled trials (RCTs) assessing the effects of phytochemicals on lipid profiles in patients with HTG. Forty-eight RCTs including 53 arms and comprising 3,478 HTG patients met the eligibility criteria. Phytochemicals significantly reduced the serum levels of triglycerides in 32 out 53 arms, total cholesterol in 22 out of 51, low-density lipoprotein cholesterol in 21 out of 48, very low-density lipoprotein cholesterol in 1 out of 5, apolipoprotein B in 2 out of 4, and lipoprotein(a) levels in 2 out of 4 arms. Furthermore, phytochemicals supplementation increased the levels of high-density lipoprotein cholesterol in 15 out of 48 arms. In brief, phytochemicals supplementation might have beneficial effects on HTG. In most of the studies, phytochemicals had a favorable effect on at least one of the lipid parameters.

Curcumin-Based Fixed Dose Combination Products for Cholesterol Management: A Narrative Review

“…Many other systematic reviews of the use of curcumin to manage cholesterol and treat metabolic disorders can be found in refs − . Results are overall positive.…”

“…From the previous section, there are many reasons why curcumin-based FDC products are attractive for cholesterol management. − Curcumin has been shown to inhibit key enzymes involved in the synthesis of cholesterol, such as HMG-CoA reductase. By reducing the activity of this enzyme, the production of cholesterol in the liver can be diminished.…”

Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

“…Nevertheless, statin drugs may lead to adverse effects in patients using multiple medications, including muscle damage, renal failure, and myopathy; in addition, scholars have suggested some risk factors associated with statin toxicity, such as alcohol abuse, frailty, multisystem diseases, gender, and age . Many preclinical and clinical studies have reported that nutraceuticals and phytochemicals from plant-based products exhibit cholesterol-lowering properties and can be potentially used as alternative medication for lowering the risks of atherosclerosis-related diseases. , Therefore, researchers have encouraged the development of plant-based health products, including health food, functional food, and dietary supplements, containing nutraceuticals with hypocholesterolemic activity (as proven by their pharmacological effects) as a sustainable intervention to retard cholesterol increase . This review focuses on recent strategies and approaches to manage hypercholesterolemia using phytochemicals within 2019–2023.…”

The effect of medicinal plants on cirrhosis: A systematic review of clinical trials

“…In addition, the anti‐diabetic and anti‐lipidemic effects of this polyphenol have previously been confirmed (Ganji et al, 2021; Mahdavi et al, 2020; Mahdavi, Bagherniya, et al, 2021; Mahdavi, Moradi, et al, 2021; Parsamanesh et al, 2018; Rafiee et al, 2021; Talebi et al, 2020). This phytochemical also has healing effects in many liver‐related diseases, including non‐alcoholic fatty liver disease (NAFLD), hepatic steatosis, and liver fibrosis (Bagherniya et al, 2018; Dadkhah Tehrani et al, 2023; Farzaei et al, 2018; Feng et al, 2019; Hassanizadeh et al, 2023; Heidari et al, 2023; Jalali et al, 2020; Lee et al, 2019; Sharifi et al, 2023; Wu et al, 2019).…”