The effects of pioglitazone in cirrhotic rats with hepatopulmonary syndrome

Cheng, Tsung Yi; Lee, Wen-shin; Lee, Fa Yauh; Chang, Ching Chih; Lin, Han Chieh; Lee, Shou Dong

doi:10.1016/j.jcma.2017.08.010

Cited by 9 publications

(5 citation statements)

References 37 publications

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“…Previous studies have demonstrated that dietary PGZ or CrMet supplementation increases ADG and the feed conversion rate (FCR). , Although there was no significant influence on the growth performance in the PGZ- or CrMet-supplemented group compared to the control in the present study, the combination of PGZ and CrMet improved growth performance by reducing the F/G and ADFI. These results may be attributed to the ability of PGZ to enhance insulin sensitization . Moreover, a diet supplemented with CrMet also increases insulin sensitization in growing calves .…”

Section: Discussionmentioning

confidence: 94%

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Dietary Supplementation with Pioglitazone Hydrochloride and Chromium Methionine Improves Growth Performance, Meat Quality, and Antioxidant Ability in Finishing Pigs

Jin

Wang

Zhang

et al. 2018

J. Agric. Food Chem.

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This work was designed to investigate the synergistic effects of pioglitazone hydrochloride (PGZ) and chromium methionine (CrMet) on meat quality, muscle fatty acid profile, and antioxidant ability of pigs. Pigs in four groups were fed a basic diet or basic diet supplemented with 15 mg/kg of PGZ, 200 μg/kg of CrMet, or 15 mg/kg of PGZ + 200 μg/kg of CrMet. In comparison to the control group, the average daily feed intake, feed/gain ratio, and serum high-density lipoprotein level decreased in the PGZ + CrMet group. Dietary PGZ + CrMet supplementation increased carcass dressing percentage, intramuscular fat, and marbling score. The percentages of C18:1ω-9c, C18:2ω-6c, C18:3ω-3, and polyunsaturated fatty acid (PUFA) in the longissimus thoracis muscle were increased in the PGZ + CrMet group. Greater superoxide dismutase and glutathione peroxidase activities were observed in the PGZ + CrMet group compared to the control group. Collectively, these findings suggested that feed with PGZ and CrMet improved the growth performance and meat quality, especially for PUFA proportions and antioxidant ability.

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Section: Discussionmentioning

confidence: 94%

“…These results may be attributed to the ability of PGZ to enhance insulin sensitization. 35 Moreover, a diet supplemented with CrMet also increases insulin sensitization in growing calves. 36 Thus, the satiety center may be stimulated by enhanced insulin, which, in turn, may decrease ingestion.…”

Section: ■ Discussionmentioning

confidence: 99%

Dietary Supplementation with Pioglitazone Hydrochloride and Chromium Methionine Improves Growth Performance, Meat Quality, and Antioxidant Ability in Finishing Pigs

Jin

Wang

Zhang

et al. 2018

J. Agric. Food Chem.

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“…Four weeks after BDL, cirrhotic rats were randomized to receive two weeks of pioglitazone before the acute LPS challenge. Without modifying blood sugar levels, this dose of chronic pioglitazone treatment can ameliorate splanchnic inflammation, decrease portosystemic shunting, and prevent hepatopulmonary syndrome in cirrhotic animals [ 24 , 25 , 26 ]. Then, to induce an acute renal dysfunction, rats were randomly allocated 6 weeks after BDL to receive an intraperitoneal injection of LPS ( Escherichia coli 0111:B4; Sigma, 0.1 mg/kg b.w, i.p.…”

Section: Methodsmentioning

confidence: 99%

“…Downregulated hepatic PPARγ expression is associated with increased systemic circulating inflammatory cytokines in BDL rats [ 23 ]. In BDL-cirrhotic rats, chronic pioglitazone treatment attenuates motor and cognition impairments and suppresses TNFα/NFκB-mediated inflammation-related portosystemic shunting and hepatopulmonary syndrome [ 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Pioglitazone Ameliorates Acute Endotoxemia-Induced Acute on Chronic Renal Dysfunction in Cirrhotic Ascitic Rats

Liu

Huang

et al. 2021

Cells

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Endotoxemia-activated tumor necrosis factor (TNFα)/nuclear factor kappa B (NFκB) signals result in acute on chronic inflammation-driven renal dysfunction in advanced cirrhosis. Systemic activation of peroxisome proliferator-activated receptor gamma (PPARγ) with pioglitazone can suppress inflammation-related splanchnic and pulmonary dysfunction in cirrhosis. This study explored the mechanism and effects of pioglitazone treatment on the abovementioned renal dysfunction in cirrhotic rats. Cirrhotic ascitic rats were induced with renal dysfunction by bile duct ligation (BDL). Then, 2 weeks of pioglitazone treatment (Pio, PPAR gamma agonist, 12 mg/kg/day, using the azert osmotic pump) was administered from the 6th week after BDL. Additionally, acute lipopolysaccharide (LPS, Escherichia coli 0111:B4; Sigma, 0.1 mg/kg b.w, i.p. dissolved in NaCl 0.9%) was used to induce acute renal dysfunction. Subsequently, various circulating, renal arterial and renal tissue pathogenic markers were measured. Cirrhotic BDL rats are characterized by decreased mean arterial pressure, increased cardiac output and portal venous pressure, reduced renal arterial blood flow (RABF), increased renal vascular resistance (RVR), increased relative renal weight/hydroxyproline, downregulated renal PPARγ expression, upregulated renal inflammatory markers (TNFα, NFκB, IL-6, MCP-1), increased adhesion molecules (VCAM-1 and ICAM-1), increased renal macrophages (M1, CD68), and progressive renal dysfunction (increasing serum and urinary levels of renal injury markers (lipocalin-2 and IL-18)). In particular, acute LPS administration induces acute on chronic renal dysfunction (increasing serum BUN/creatinine, increasing RVR and decreasing RABF) by increased TNFα-NFκB-mediated renal inflammatory markers as well as renal M1 macrophage infiltration. In comparison with the BDL+LPS group, chronic pioglitazone pre-treatment prevented LPS-induced renal pathogenic changes in the BDL-Pio+LPS group. Activation of systemic, renal vessel and renal tissue levels of PPARγ by chronic pioglitazone treatment has beneficial effects on the endotoxemia-related TNFα/NFκB-mediated acute and chronic renal inflammation in cirrhosis. This study revealed that normalization of renal and renal arterial levels of PPARγ effectively prevented LPS-induced acute and chronic renal dysfunction in cirrhotic ascitic rats.

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“…Responsiveness of insulin-dependent tissues increased due to metabolic changes produced by pioglitazone. As pioglitazone increases the response of circulating insulin by reducing insulin resistance, it does not decrease blood sugar level in animal models that are deficient in endogenous insulin [5,6].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Robustness of Spectrophotometric Method and High-Performance Liquid Chromatographic Method for the Determination of Pioglitazone in Solid Dosage Form

Zahid

Ahmed

et al. 2021

JPRI

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Pioglitazone is a drug that reduces the amount of glucose (sugar) in the blood. It is included in the class of anti-diabetic drugs called “thiazolidinedione” that are used in the treatment of type II diabetes. It attaches to the peroxisomes proliferated- activated receptor gamma (PPARϒ) on tissues throughout the body and causes the cells to become more sensitive to insulin. As a result, more glucose is removed from the blood.The aim of the study is more precisely to find out the better analytical method for the quantitative measurement of the content of pioglitazone in commercially available drugs using two analytical methods i-e Spectrophotometric method and HPLC method.The analytical method for the pioglitazone hydrochloride was developed by HPLC, and then validated the method according to compendial requirements. Pioglitazone in various Dowglit and Gliden tablets was determined by this developed methodPrecision, Accuracy and stability of Pioglitazone was checked which came out to be100.40% and 100.19% respectively. The analysis of pioglitazone hydrochloride in solid dosage form using the HPLC method shows the results are more sensitive, accurate, validated and economical and can be easily applied to raw materials and finished goods compared to the Spectrophotometer method.

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The effects of pioglitazone in cirrhotic rats with hepatopulmonary syndrome

Abstract: Pioglitazone down-regulated VEGF, eNOS and decreased intrapulmonary shunts without improving oxygenation. The current finding suggests a multifactorial mechanism of HPS that could not be successfully overcome merely by pioglitazone-induced anti-angiogenesis and shunting reduction.

Cited by 9 publications

References 37 publications

Dietary Supplementation with Pioglitazone Hydrochloride and Chromium Methionine Improves Growth Performance, Meat Quality, and Antioxidant Ability in Finishing Pigs

Dietary Supplementation with Pioglitazone Hydrochloride and Chromium Methionine Improves Growth Performance, Meat Quality, and Antioxidant Ability in Finishing Pigs

Pioglitazone Ameliorates Acute Endotoxemia-Induced Acute on Chronic Renal Dysfunction in Cirrhotic Ascitic Rats

Comparison of the Robustness of Spectrophotometric Method and High-Performance Liquid Chromatographic Method for the Determination of Pioglitazone in Solid Dosage Form

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