The Effects of Plasmodium Falciparum Parasitaemia on Liver Synthetic Fidelity and Oxidative Stress Markers

Abstract

Malaria has for century’s defiled eradication due to pathophysiological and environmental complexities. The study was aimed at revealing the effect of malaria parasitaemia on hepatic synthetic fidelity and oxidative stress markers individually and synergistically. A total of five hundred subjects constituted the sample size, out of which two hundred comprised the control and three hundred the test group with grades of parasitaemia. Serum aspartate aminotransferases (AST), alanine aminotransferase (ALT), iron, malonaldehyde and glutathione were analysed using WHO approved methods. The results obtained indicated a significant increase (p<0.05) in AST, ALT, malonaldehyde, and glutathione levels in malaria infected subjects when compared to the control group respectively. The result further showed a significant decrease (p<0.01) in serum iron concentration in malaria infected groups when compared to the control. In conclusion, malaria infection has a significant impact on the hepatic synthetic capacity and oxidative indicators. It is suggested that these observed biochemical change should be considered when malaria infected individuals are treated and managed.

Increased Blood Concentrations of Malondialdehyde in Plasmodium Infection: A Systematic Review and Meta-Analysis

“…It is generated by free radicals that cause membrane lipid peroxidation and has been shown to deplete antioxidant levels, increase proinflammatory cytokines, and increase oxidative stress [ 56 ]. The present study confirmed previous reports of increased MDA levels in participants with malaria compared with uninfected controls [ 7 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 47 , 48 , 49 , 50 , 53 , 54 , 55 ]. It is possible that lipid peroxidation on erythrocyte membranes—which are vulnerable to oxidative damage—is the cause of the elevated MDA levels found in malaria patients.…”

“…The remaining 72 full-text articles were examined against the eligibility criteria, and those that failed to meet them were excluded with a clear explanation, leaving 19 articles [ 7 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ] for inclusion in our review. Additionally, four articles [ 52 , 53 , 54 , 55 ] were identified from Google Scholar that also met the inclusion criteria. Thus, a total of 23 studies [ 7 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] were included for review ( Figure 1 ).…”

“…Additionally, four articles [ 52 , 53 , 54 , 55 ] were identified from Google Scholar that also met the inclusion criteria. Thus, a total of 23 studies [ 7 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] were included for review ( Figure 1 ).…”

“…The remaining 72 full-text articles were examined against the eligibility criteria, and those that failed to meet them were excluded with a clear explanation, leaving 19 articles [7,[34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] for inclusion in our review. Additionally, four articles [52][53][54][55] were identified from Google Scholar that also met the inclusion criteria. Thus, a total of 23 studies [7, were included for review (Figure 1).…”

“…A qualitative synthesis showed increased MDA concentrations in participants with malaria compared with uninfected controls in 19 studies [7,34,[36][37][38][39][40][41][42][43][44][45][47][48][49][50][53][54][55]. Two studies [35,46] showed no difference in MDA concentrations between malaria patients and uninfected controls.…”