The effects of platelet-rich fibrin on post-surgical complications following removal of impacted wisdom teeth: A pilot study

Abstract

Objectives Platelet-rich fibrin (PRF) is a fibrin matrix composed of cells, cytokines, and growth factors, which may be liberated from blood at specific times and act as a resorbable membrane. Many studies have demonstrated the benefits of PRF for bone healing in oral and maxillofacial implant surgery. Our study assesses the impact of PRF on postoperative complications following the extraction of impacted wisdom teeth. Methods Twenty patients were recruited in this blind controlled randomised clinical trial, i.e. ten patients in the study group and ten patients in the control group. The patients were aged between 18 and 40 years. Surgical removal of impacted teeth #38 and #48 was performed in all the patients. The study group underwent dentoalveolar surgery with the use of PRF, while the control group underwent surgery without PRF. Results All patients in the study group reported significantly less postoperative pain ( p = 0.02) and excellent soft tissue healing during the follow-up period ( p = 0.021). In contrast, only 80% of patients in the control group exhibited sufficient soft tissue healing. The difference in postoperative swelling between the two groups was not statistically significant. Additionally, 69% of patients in the study group reported comfortable night sleep during the first 24 h after the operation compared to 31% in the control group. This difference was statistically significant (p = 0.02). Conclusion Based on the outcomes of our study, implanting PRF into surgical extraction sites can be helpful in reducing postoperative pain and improving soft tissue healing. The use of PRF in extraction sockets is simple and biologically safe. The beneficial effects of PRF support its possible application in the field of dental surgery.

Platelet-rich fibrin combined with new bone graft material for mandibular defect repair: A <i>in vivo</i> study on rabbits

“…The research group co-cultured MC with human bone marrow mesenchymal stem cells in the early stage to confirm the osteogenic properties of MC. PRF developed by Choukroun 32) is a secondgeneration biomaterial obtained by centrifugation of autologous blood, rich in platelets and leukocytes, and acts as a fibrin scaffold and a modulator of various cytokines, producing fibrin and cell migration, promoting tissue healing 33) . Numerous studies have shown that PRF can gradually release its cytokines and cells 34,35) .…”

Clinical and Radiographic Evaluation of Autologous Platelet-Rich Fibrin With or Without Demineralized Bone Matrix in the Treatment of Grade II Furcation Defects

“…Multiple studies have revealed that while it promotes the formation of osteoblasts, gingival fibroblasts, and periodontal ligament cells, it suppresses the growth of oral epithelial cells [ 69 - 71 ]. PRF may help heal periodontal osseous abnormalities [ 72 ] because it can regulate the expression of phosphorylated extracellular signal-regulated protein kinase [ 73 , 74 ] and prevent osteoclastogenesis by inducing the formation of osteoprotegerin in the bone [ 73 , 75 , 76 ].…”

Influence of inflammation on bleeding and wound healing following surgical extraction of impacted lower third molars

“…Post-extraction bleeding was assessed on a five-point scale, with grade 0 indicating no bleeding; grade I indicating very mild bleeding; grade II indicating mild bleeding; grade III indicating moderate bleeding, and grade IV indicating severe bleeding [ 12 ].…”