The effects of polyacrylamide hydrogel in normal and osteoarthritic animal joints

Christensen, Lise; Camitz, L.; Illigen, K.E.; Hansen, M. Lock; Sarvaa, R.; Conaghan, P.

doi:10.1016/j.joca.2016.01.818

Cited by 4 publications

(3 citation statements)

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“…Several other classes of polymeric lubricants are not mimetic, per se , of native tissue lubricants; however, they are structurally and functionally inspired by biologically occurring hydrophilic macromolecules. Lightly crosslinked polyacrylamide networks demonstrate symptom-improving effects in goats, horses, and humans following intraarticular injection [191–194] such products are not currently approved for human use in the United States. Some evidence suggests the mechanism of polyacrylamide’s reduction of osteoarthritis symptoms involves lubrication of articular surfaces, while other evidence purports cushioning of loads and yet additional findings demonstrate integration of the polymer network into the joint synovial lining to provide proximal soft tissues with increased elasticity.…”

Section: Therapeutic Strategiesmentioning

confidence: 99%

Active agents, biomaterials, and technologies to improve biolubrication and strengthen soft tissues

et al. 2018

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Normal functioning of articulating tissues is required for many physiological processes occurring across length scales from the molecular to whole organism. Lubricating biopolymers are present natively on tissue surfaces at various sites of biological articulation, including eyelid, mouth, and synovial joints. The range of operating conditions at these disparate interfaces yields a variety of tribological mechanisms through which compressive and shear forces are dissipated to protect tissues from material wear and fatigue. This review focuses on recent advances in active agents and biomaterials for therapeutic augmentation of friction, lubrication, and wear in disease and injured states. Various small-molecule, biological, and gene delivery therapies are described, as are tribosupplementation with naturally-occurring and synthetic biolubricants and polymer reinforcements. While reintroduction of a diseased tissue's native lubricant received significant attention in the past, recent discoveries and pre-clinical research are capitalizing on concurrent advances in the molecular sciences and bioengineering fields, with an understanding of the underlying tissue structure and physiology, to afford a desired, and potentially patient-specific, tissue mechanical response for restoration of normal function. Small and large molecule drugs targeting recently elucidated pathways as well as synthetic and hybrid natural/synthetic biomaterials for restoring a desired tissue mechanical response are being investigated for treatment of, for example, keratoconjunctivitis sicca, xeroderma, and osteoarthritis.

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Section: Therapeutic Strategiesmentioning

confidence: 99%

Active agents, biomaterials, and technologies to improve biolubrication and strengthen soft tissues

et al. 2018

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“…Hydrogels may be produced from synthetic polymers such as polyacrylamide (PAM) [7] or natural polymers, such as chitosan, among others [8][9][10][11]. The great advantage in the use of natural polymers is the ability to interact with cells and cellular enzymes and to be remodeled and/or degraded to provide a place for tissue growth [12].…”

Section: Introductionmentioning

confidence: 99%

Chitosan Hydrogels Crosslinked by Genipin and Reinforced with Cellulose Nanocrystals: Production and Characterization

Pomari

Montanheiro²,

Siqueira

et al. 2019

J. Compos. Sci.

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In this work, chitosan hydrogels crosslinked with genipin and reinforced with cellulose nanocrystals (CNC) were developed and characterized with the aim of future biomedical applications. CNC was produced by acid hydrolysis and characterized by atomic force microscopy (AFM). Chitosan/CNC nanocomposite hydrogels were produced with different CNC concentrations (w/w): 0%, 2%, 4%, and 6%. The genipin was used as a crosslinking agent in a genipin/chitosan molar proportion of 1:8. The hydrogels were characterized by porosity measurements, scanning electron microscopy (SEM), swelling test, and mechanical compression test. No significant differences were observed concerning the porosity of the hydrogels; however, a trend of decreasing porosity was observed with increasing CNC content. The SEM images showed a better pore structure as the CNC concentration increased. A decrease in the swelling degree with increasing CNC content in the chitosan/CNC nanocomposite hydrogel was verified in the swelling tests. An increase in the CNC concentration in the chitosan/CNC nanocomposite hydrogel caused a gradual increase in the maximum stress and maximum strain as observed in the compression tests, showing a significant difference between chitosan/CNC 6 wt % and neat chitosan hydrogel.

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“…This is one approach to lower the COF, and other strategies investigated include the use of lubricin,[34-36] lubricin-mimetics,[32, 33, 37-39] liposomes,[40, 41] and other high-molecular-weight lubricious polymers. [42-45] These and other efforts to improve the biotribological properties of articular cartilage have been reviewed recently. [46, 47] The design criteria and rationale for the biolubricant described herein include: lack of glycosidic linkages to prevent degradation; a molecular weight greater than 1 MDa to increase joint resident time; hydrophilic repeat units within the polymer for water solubility inspired by hyaluronic acid; an overall polymer negative charge to maintain the polymer at the cartilage surface; shear thinning properties to allow for delivery using a small gauge needle; low COF to reduce wear, and preparation of the polymer via chemical synthesis giving a well defined polymer.…”

Section: Introductionmentioning

confidence: 99%

A synthetic polymeric biolubricant imparts chondroprotection in a rat meniscal tear model

et al. 2018

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Intra-articular injection of hyaluronic acid (HA) is used to treat osteoarthritis (OA) as a viscosupplement, yet it only provides short-term benefit because HA is cleaved by hyaluronidase and cleared out of the joint after several days. Therefore, we developed a new polymer biolubricant based on poly-oxanorbornane carboxylate to enhance joint lubrication for a prolonged time. Rheological and biotribological studies of the biolubricant reveal viscoelastic properties and coefficient of friction equivalent and superior to that of healthy synovial fluid, respectively. Furthermore, in an ex vivo bovine cartilage plug model, the biolubricant exhibits superior long-term reduction of friction and wear prevention compared to saline and healthy synovial fluid. ISO 10993 biocompatibility tests demonstrate that the biolubricant polymer is non-toxic. In an in vivo rat medial meniscal tear OA model, where the performance of the leading HA viscosupplement (Synvisc-one) is comparable to the saline control, treatment with the biolubricant affords significant chondroprotection compared to the saline control.

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The effects of polyacrylamide hydrogel in normal and osteoarthritic animal joints

Cited by 4 publications

References 0 publications

Active agents, biomaterials, and technologies to improve biolubrication and strengthen soft tissues

Active agents, biomaterials, and technologies to improve biolubrication and strengthen soft tissues

Chitosan Hydrogels Crosslinked by Genipin and Reinforced with Cellulose Nanocrystals: Production and Characterization

A synthetic polymeric biolubricant imparts chondroprotection in a rat meniscal tear model

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