The effects of polybrominated biphenyls and perchlorinated terphenyls on in vitro fertilization in the mouse

Kholkute, S. D.; Rodriguez, J. A.; Dukelow, W. Richard

doi:10.1007/bf00224806

Cited by 13 publications

(8 citation statements)

References 22 publications

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“…Animal studies have demonstrated that PCBs cause reduced oocyte maturation (reviewed by Pocar et al 2006), increased embryo degeneration and decreased embryo cell proliferation, blastocyst formation and blastocyst development, and decreased IVF success rates (Campagna et al 2001, 2002; Kholkute and Dukelow 1997; Kholkute et al 1994a, 1994b; Krogenaes et al 1998; Kuchenhoff et al 1999; Lindenau and Fischer 1996; Pocar et al 2001), along with increased implantation failures (Linder et al 1974), increased resorptions (Arnold et al 1995), and decreased litter production (Jonsson et al 1975; Seiler et al 1994). PCB impacts on uterine receptivity may also contribute to an increased risk of implantation failure.…”

Section: Discussionmentioning

confidence: 99%

Serum Concentrations of Polychlorinated Biphenyls in Relation to in Vitro Fertilization Outcomes

Meeker

Maity

Missmer

et al. 2011

Environ Health Perspect

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Background: Human exposure to polychlorinated biphenyls (PCBs) remains widespread. PCBs have been associated with adverse reproductive health outcomes including reduced fecundability and increased risk of pregnancy loss, although the human data remain largely inconclusive.Objective: Our goal was to explore the relationship between serum PCB concentrations and early pregnancy loss among a large cohort of women undergoing in vitro fertilization (IVF) between 1994 and 2003.Methods: Concentrations of 57 PCB congeners were measured in serum samples collected during 827 IVF/intracytoplasmic sperm injection cycles from 765 women. Joint statistical models that accommodate multiple outcomes and multiple cycles per woman were used to assess the relationship between serum PCB quartiles and implantation failure, chemical pregnancies (human chorionic gonadotropin level > 5.0 mIU/mL) that did not result in clinical pregnancy, or spontaneous abortion, while also adjusting for confounders.Results: PCB-153 was the congener present in the highest concentration (median, 46.2 ng/g lipid). Increasing quartiles of PCB-153 and the sum of all measured PCB congeners (ΣPCBs) were associated with significantly elevated dose-dependent odds of failed implantation. Adjusted odds ratios (95% confidence interval) for highest versus lowest quartile were 2.0 (1.2–3.4) for PCB-153 and 1.7 (1.0–2.9) for ΣPCBs. There were suggestive trends for increased odds of implantation failure for PCB-118 and cytochrome P450–inducing congeners (p-values for trend = 0.06). No statistically significant associations between PCBs and chemical pregnancy or spontaneous abortion were found.Conclusions: Serum PCB concentrations at levels similar to the U.S. general population were associated with failed implantation among women undergoing IVF. These findings may help explain previous reports of reduced fecundability among women exposed to PCBs.

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Section: Discussionmentioning

confidence: 99%

Serum Concentrations of Polychlorinated Biphenyls in Relation to in Vitro Fertilization Outcomes

Meeker

Maity

Missmer

et al. 2011

Environ Health Perspect

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“…Preliminary observations indicated that human embryos, derived from oocytes contained in follicles with elevated pollutant concentrations had low cleavage rate as observed after IVF [49]. Kholkute et al [50,51] tested the effects of EDs mixtures, such as Aroclor 1254 and 1268, on the in vitro maturation and fertilization of mouse oocytes. Their results Aromatase 5-alpha-reductase type 1 5-alpha-reductase type 2 Fig.…”

Section: Female Reproductionmentioning

confidence: 97%

Effects of Endocrine Disruptors on Developmental and Reproductive Functions

Brevini¹,

Zanetto²,

Cillo³

2005

curr drug targets immune endocr metabol disord

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Endocrine disruptors (EDs) are exogenous environmental molecules that may affect the synthesis, secretion, transport, metabolism, binding, action, and catabolism of natural hormones in the body. EDs may thus interact with the endocrine system of animals and humans and can exert this effect even when present in minute amounts. EDs have adverse impacts on a number of developmental functions in wildlife and humans. Critical periods of urogenital tract and nervous system development in-utero and during early post-natal life are especially sensitive to hormonal disruption. Furthermore a wide range of hormone-dependent organs (pituitary gland, hypothalamus, reproductive tract) are targets of EDs disrupting effects in adult subjects, possibly resulting in cell transformation and cancer. At present about 60 chemicals have been identified and characterized as EDs and belong to three main groups: (a) synthetic compounds utilized in industry, agriculture and consumer products; (b) synthetic molecules used as pharmaceutical drugs and (c) natural chemicals found in human and animal food (phytoestrogens). In the present review we will give special attention to the family of Polychlorinated biphenyls (also indicated as PCBs) because of their persistence in the environment, ability to concentrate up the food chain, continued detection in environmental matrices, and ability to be stored in the adipose tissue of animals as well as humans. The detrimental effects of these compounds, and of EDs more in general, on health and reproduction will be discussed, presenting experimental data aimed at understanding the molecular mechanisms involved in their action.

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“…In an in vitro study, Kholkute and Dukelow (1997) found that a mixture of PCBs resulted in adverse effects on fertilization, oocytes, and 2-cell embryos in the mouse without additive or synergistic effects. Fargasová ( 1997) that toxicity of metals (V, Mo, Mn, Ni, and Cu metal ions) in combination was different from that of individual metals to Chironomus plumosus larvae.…”

Section: Polycyclic Aromatic Hydrocarbons (Pahs)mentioning

confidence: 97%

Organochlorine, PCB, PAH, and metal concentrations in eggs of loggerhead sea turtles (Caretta caretta)from northwest Florida, USA

Alam

Brim²

2000

Journal of Environmental Science and Health, Part B

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Composite samples of unhatched and physically unaltered loggerhead sea turtle, Caretta caretta, eggs collected from 20 nests along northwest Florida were analyzed for organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and metals. Chemical analyses revealed that turtle eggs contained detectable amounts of metals, PAHs, and PCBs. Only one OCP, p,p'-DDD, was detected, and its presence was restricted to eggs from two nesting sites. None of the PCB concentrations exceeded the Food and Drug Administration's (FDA) action limit. Concentrations of dioxin-like PCB congeners, 105, 118, and 126, and total PCBs were also detected and are contributors to the toxic burden of loggerhead sea turtle eggs. Concentrations of PAHs, 1,2,5,6-dibenzanthracene, 1-methyl naphthalene, C1-naphthalene and naphthalene were variable at nesting sites. Comparison of mean metal burdens in eggs from different beaches suggested that no uniform geographic gradients exist. Presence of OCPs, PCBs, PAHs and metals and their additive or synergistic toxicity is a concern to loggerhead sea turtle eggs; however, additive or synergistic impacts for loggerhead sea turtles are largely undocumented.

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The effects of polybrominated biphenyls and perchlorinated terphenyls on in vitro fertilization in the mouse

Cited by 13 publications

References 22 publications

Serum Concentrations of Polychlorinated Biphenyls in Relation to in Vitro Fertilization Outcomes

Serum Concentrations of Polychlorinated Biphenyls in Relation to in Vitro Fertilization Outcomes

Effects of Endocrine Disruptors on Developmental and Reproductive Functions

Organochlorine, PCB, PAH, and metal concentrations in eggs of loggerhead sea turtles (Caretta caretta)from northwest Florida, USA

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