The effects of preanesthetic, single-dose dexmedetomidine on induction, hemodynamic, and cardiovascular parameters

Başar, Hülya; Akpinar, Serpil; Doganci, N.; Büyükkoçak, Ünase; Kaymak, Çetin; Sert, Ozgur; Apan, Alpaslan

doi:10.1016/j.jclinane.2008.04.007

Cited by 91 publications

(98 citation statements)

References 15 publications

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“…The present study was in accordance with the studies done by Basar et al 17 Bhattachargee et al evaluated the efficacy of dexmedetomidine in patients undergoing laparoscopic cholecystectomy. They observed significantly lower mean arterial pressure and heart rate in patients of dexmedetomidine group after intubation and throughout the period of pneumoperitoneum.…”

Section: Discussionsupporting

confidence: 89%

Clinical efficacy of dexmedetomidine in two different doses to attenuate the hemodynamic changes during laparoscopic cholecystectomy

Masoori¹,

Gupta²,

Agarwal³

et al. 2018

Int J Res Med Sci

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Background: Laryngoscopy and laparoscopy lead to predictable hemodynamic changes. Dexmedetomidine is selective 2 agonist with dose dependent sedation, sympatholysis and analgesia, hence could provide stable hemodynamics during laparoscopic surgeries. The present study was aimed to compare the clinical efficacy of dexmedetomidine infusion in two different doses to attenuate the hemodynamic variations during laparoscopic cholecystectomy.Methods: Total 60 adult patients of ASA physical status I and II of both gender, scheduled for elective laparoscopic cholecystectomy, were randomly allocated into two groups of 30 patients. All patients were infused with loading dose of dexmedetomidine (1µg/kg) before induction. Patients of Group 1 received maintenance infusion of dexmedetomidine in doses of 0.3µg/kg/h and patients of Group 2 received maintenance infusion of dexmedetomidine in doses of 0.6µg/kg/h, continued till the end of surgery. Heart rate and blood pressure were recorded preoperatively, after dexmedetomidine administration, after induction, intubation, after creation of pneumoperitoneum and postoperatively. Intraoperative changes in heart rate and blood pressure were noted as primary variables and dexmedetomidine related side effects were noted as secondary outcomes, for statistical analysis.Results: The hemodynamic responses were attenuated in patients of both groups after laryngoscopy, intubation and creation of pneumoperitoneum but patients of Group 2 (0.6µg/kg/h) showed more stability in hemodynamics. The difference between the group was statistically significant (p value=0.001). No any evident complication or side effects occurred.Conclusions: Dexmedetomidine infusion was effective for attenuating the hemodynamic changes due to laryngoscopy and laparoscopy but were better with maintenance infusion of dexmedetomidine in dose of 0.6µg/kg/h.

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Section: Discussionsupporting

confidence: 89%

Clinical efficacy of dexmedetomidine in two different doses to attenuate the hemodynamic changes during laparoscopic cholecystectomy

Masoori¹,

Gupta²,

Agarwal³

et al. 2018

Int J Res Med Sci

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show abstract

“…In our patients, the addition of dexmedetomidine to bupivacaine causes a significant decrease in the MAP and HR intra-operatively. Similar result was recorded that the effect of single dose of 0.5 μg/kg dexmedetomidine administered 10 min before induction of anesthesia and reported significant reduction in MAP and HR [22,23]. Al-Ghanem et al [9] have reported the use of dexmedetomidine to be associated with a decrease in heart rate and mean blood pressure.…”

Section: Discussionsupporting

confidence: 71%

Bupivacaine-Dexmedetomidine for Lumber Discectomy: Randomized Controlled Placebo Study

Mohamed¹,

Salem²

2015

J Anesth Clin Res

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“…Intravenous dexmedetomidine premedication before general anesthesia provides preoperative sedation, analgesia, and hemodynamic stability and reduces requirements for intraoperative inhalational agents and postoperative analgesics. [1][2][3] Also, it has been used safely as premedication or as a sedative agent in patients undergoing surgical procedures under regional anesthesia. 4,5 Although a synergistic interaction between intrathecal dexmedetomidine and local anesthetics has been observed in previous studies, [6][7][8][9] there are no clinical data regarding the effect of intravenous dexmedetomidine premedication on the duration of sensory and motor block during spinal anesthesia.…”

Section: Introductionmentioning

confidence: 99%

Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia

Kaya

Yavaşçaoğlu

Türker

et al. 2009

Can J Anesth/J Can Anesth

126

129

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The effects of preanesthetic, single-dose dexmedetomidine on induction, hemodynamic, and cardiovascular parameters

Cited by 91 publications

References 15 publications

Clinical efficacy of dexmedetomidine in two different doses to attenuate the hemodynamic changes during laparoscopic cholecystectomy

Clinical efficacy of dexmedetomidine in two different doses to attenuate the hemodynamic changes during laparoscopic cholecystectomy

Bupivacaine-Dexmedetomidine for Lumber Discectomy: Randomized Controlled Placebo Study

Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia

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