The effects of prenatal nicotine on radial-arm maze performance in rats

Sorenson, Charles A.; Raskin, Lisa A.; Suh, Yongsook

doi:10.1016/0091-3057(91)90117-k

Cited by 100 publications

(59 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The poor spatial navigation observed in the present study might be due to the direct effect of nicotine on developing pups in utero, as it can cross the placental barrier and affect the developing brain (27,28). Prenatal nicotine exposure has resulted in spatial memory deficits in the Morris water maze and radial-arm maze tasks in prepubertal, adolescent, and adult rats (13,29,30). It is sug-gested that these cognitive changes may be the result of long-lasting alterations to the nicotinic and adrenergic neuro-transmitter systems following in utero exposure to nicotine (30).…”

Section: Discussionmentioning

confidence: 83%

See 1 more Smart Citation

Ascorbic Acid Ameliorates Nicotine Exposure Induced Impaired Spatial Memory Performances in Rats

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 83%

“…Nicotine, the major component of tobacco, is proven to be a neuroteratogen (8)(9)(10). Evidence from animal studies has confirmed that nicotine can cause deficits in learning and memory (11)(12)(13)(14). After nicotine exposure in utero, attention and memory deficits were observed in adult offspring of rats and mice (13,15).…”

Section: Introductionmentioning

confidence: 99%

Ascorbic Acid Ameliorates Nicotine Exposure Induced Impaired Spatial Memory Performances in Rats

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Numerous studies have shown a wide range of behavioral impairments in rodents prenatally exposed to nicotine, including impaired performance in the radial arm maze and Morris water maze (Levin et al 1993;Sorenson et al 1991;Yanai et al 1992), lower response and reinforcement rates under operant schedules of food delivery (Martin and Becker 1971), poorer operant discrimination performance (Martin and Becker 1971), and reduced pre-pulse inhibition of acoustic startle response . Although several animal studies have found that offspring prenatally exposed to nicotine can also exhibit hyperactivity (Ajarem and Ahmad 1998;Fung and Lau 1989;Martin and Becker 1970;Peters et al 1979;Vaglenova et al 2004), other studies have reported conflicting results (see Table 1).…”

Section: Introductionmentioning

confidence: 99%

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

LeSage

Gustaf

Dufek

et al. 2006

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Maternal tobacco use is associated with adverse developmental outcomes in offspring, including hyperactivity. Animal studies attempting to model this phenomenon have primarily used continuous s.c. nicotine infusion as the method of nicotine administration, which does not model the intermittent bolus delivery of nicotine associated with smoking in humans. The purpose of the present experiment was to examine the locomotor activity of pre-weanling offspring of pregnant rats exposed to an i.v. nicotine dosing protocol that approximates the pattern of nicotine exposure in moderate to heavy smokers. Pregnant rats were administered an i.v. bolus of 0.03 mg/kg nicotine (N=13) or saline (N=10) every 14 min for 16 hr/day, resulting in a total daily dose of 2 mg/kg (base), from gestational day 4 to delivery. Pups from each litter were tested for spontaneous locomotor activity on postnatal days (PND) 19-21 and nicotine-induced locomotor activity on PND 22. Mean birth weight was significantly lower in nicotine-exposed pups compared to controls, but body weights were equivalent between groups by the time of behavioral testing. Mean total distance traveled, vertical counts, and stereotypy counts were lower on PND 19 in nicotine-exposed pups compared to controls, but only the difference in mean stereotypy counts was statistically significant. Within session analysis revealed that both distance traveled and stereotypy were significantly decreased in nicotine-exposed pups in the first five minutes of the session on PND 19. Total time spent in the center of the field was also lower in nicotine exposed pups. Nicotine-induced increases in activity on PND 22 did not differ according to gestational exposure. These findings demonstrate that prenatal nicotine exposure in a model that mimics the pattern of nicotine exposure from cigarette smoking in humans results in offspring that exhibit low birth weight and hypoactivity in a novel environment.

show abstract

“…These animal models show deficits in attention and memory in maze performance (Levin et al, 1993;Sorenson et al, 1991), in learning (Levin et al, 1993), and in operant behaviors (Martin and Becker, 1971). Prenatal NIC exposure is associated with problems with neuronal growth and path-finding (Zheng, 1994), and cell proliferation and differentiation (Lajtha, 1985;Slotkin et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Smoking during pregnancy: Postnatal effects on arousal and attentional brain systems

et al. 2007

View full text Add to dashboard Cite

Prenatal exposure to cigarette smoke is known to produce lasting arousal, attentional and cognitive deficits in humans. The pedunculopontine nucleus (PPN), as the cholinergic arm of the reticular activating system (RAS), is known to modulate arousal, waking and REM sleep. Rapid eye movement (REM) sleep decreases between 10 and 30 days postnatally in the rat, with the greatest decrease occurring at 12-21 days. Pregnant dams were exposed to 150 ml of cigarette smoke for 15 min, 3 times per day, from day E14 until parturition, and the pups allowed to mature. We analyzed a) intrinsic membrane properties of PPN neurons in slices from pups aged 12-21 days, and b) the sleep state-dependent P13 auditory evoked potential, which is generated by PPN outputs, in animals allowed to age to adolescence. We found significant changes in the intrinsic membrane properties of PPN cells in prenatally exposed animals compared to intact ones, rendering these cells more excitable. In addition, we found disturbances in the habituation to repetitive stimulation in adolescent, freely moving animals, suggestive of a deficit in the process of sensory gating. These findings could explain some of the differences seen in individuals whose parents smoked during pregnancy, especially in terms of their hypervigilance and increased propensity for attentional deficits and cognitive/behavioral disorders.

show abstract

The effects of prenatal nicotine on radial-arm maze performance in rats

Cited by 100 publications

References 13 publications

Ascorbic Acid Ameliorates Nicotine Exposure Induced Impaired Spatial Memory Performances in Rats

Ascorbic Acid Ameliorates Nicotine Exposure Induced Impaired Spatial Memory Performances in Rats

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

Smoking during pregnancy: Postnatal effects on arousal and attentional brain systems

Contact Info

Product

Resources

About