The effects of pretreatment with lithium metaborate dihydrate on lipid peroxidation and Ca, Fe, Mg, and K levels in serum of Wistar albino male rats exposed to Cd

Taşdemir, Muhammed; Çelikezen, Fatih Çağlar; Oto, Gökhan; Özbey, Fahrettin

doi:10.1007/s11356-019-07516-6

Cited by 8 publications

(2 citation statements)

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“…In another study, it was determined that 50 and 500 mg/L doses of borax, boric acid, and ulexite significantly decreased GSH-Px levels of human blood cultures, decreases occurring in total GSH level were statistically significant at 500 mg/L of dose, and was not statistically significant at 50 mg/L of dose [43]. Recently, it was stated that GSH status indicated a statistically important decrease (p< 0.05) in lithium metaborate dihydrate induced group according to the control [42]. As the results obtained from the present study were examined; GSH levels of all groups showed a statistically significant decrease compared to control group (Figure 2).…”

Section: Resultsmentioning

confidence: 97%

“…Another study revealed that in rats administered with different levels of boric acid, MDA levels of the group fed with diet containing 40 mg boric acid decreased compared to control group [41]. Recently, it was reported that MDA status indicated a statistically important decrease (p< 0.05) in lithium metaborate dihydrate induced group according to the control [42]. An in vitro study, it was determined that MDA levels of human blood cultures which were administered with 15 µmol ulexite decreased according to the control, but decline was not statistically important [43].…”

Section: Resultsmentioning

confidence: 97%

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The Protective Effects of Borax on Doxorubicin Induced Cardiotoxicity In Rats

Çelikezen

Tanyıldızı

Oto

2021

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi

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Boron and boron compounds have benefical effects on health of human and animals.This study was designed to determine the protective effect of borax (BX) in doxorubicin (DXR) induced cardiotoxicity in rats. In this study, 20 Wistar-Albino male rats * were used. The rats were divided into four groups including 5 rats in each one; control group (standard pellet food + water + normal saline), doxorubicin (3.75 mg/kg/ip, single dose in a week), doxorubicin + borax (3,75 mg/kg/ip + 25 mg/kg/oral/ respectively), and borax (25 mg/kg/oral, single dose in a week). At the end of the experiment, to evaluate antioxidant activity MDA, GSH, CAT, SOD levels determined in blood samples of rats. Besides, CK levels were investigated to determine the effect of doxorubucine on heart tissue. According to the results, MDA levels increased significantly in doxorubucin induced group (p<0.05). After borax treatment MDA status decreased under the control values (p<0.05). GSH status decreased in all groups. While CAT level decreased in DXR induced group in a statistically important rate (p<0.05), it was observed near control values in BX and BX+DXR induced groups. SOD status indicated increase in BX and DXR groups. In addition, CK levels increased in all groups compared to the control. In the increases only in DXR induced group, significance was determined as p<0.05. As a result, these data indicated that borax may use to prevent cardiotoxic effect of doxorubicin.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 97%

The Protective Effects of Borax on Doxorubicin Induced Cardiotoxicity In Rats

Çelikezen

Tanyıldızı

Oto

2021

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi

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Cadmium influence on lipid metabolism in Sprague–Dawley rats through linoleic acid and glycerophospholipid metabolism pathways

Dong

Zhao

Yin

et al. 2023

J Biochem & Molecular Tox

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Cadmium (Cd) is widely distributed in the environment and easy adsorbed by living organisms with adverse effects. Exposure to Cd‐contaminated food may disrupt lipid metabolism and increase human health risk. To study the perturbation effect of Cd on lipid metabolism in vivo, 24 male Sprague–Dawley (SD) rats were randomly assigned four groups and treated by Cd chloride solution (0, 1.375 mg/kg, 5.5 mg/kg, 22 mg/kg) for 14 days. The characteristic indexes of serum lipid metabolism were analyzed. Afterwards, untargeted metabolomics analysis was applied to explore the adverse effects of Cd on rats by liquid chromatography coupled with mass spectrometry (LC‐MS). The results revealed that Cd exposure obviously decreased the average serum of triglycerides (TG) and low‐density lipoprotein cholesterol (LDL‐C) and caused an imbalance of endogenous compounds in the 22 mg/kg Cd‐exposed group. Compared with the control group, 30 metabolites with significant differences were identified in the serum. Our results indicated that Cd caused lipid metabolic disorders in rats by disrupting linoleic acid and glycerophospholipid metabolism pathways. Furthermore, there were three kinds of remarkable differential metabolites—9Z,12Z‐octadecadienoic acid, PC(20:4(8Z,11Z,14Z,17Z)/0:0), and PC(15:0/18:2(9Z,12Z)), which enriched the two significant metabolism pathways and could be the potential biomarkers.

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