Introduction: Urinary stones are among major urological diseases. Open kidney surgery has always been of historical importance in the management of most urinary stones, especially in complicated cases. The aim of this study was to investigate the cases of open kidney stone surgery in Amir Al-Momenin hospital of Zabol in 2016-2017. Method: In the present descriptive cross-sectional study, the patients who underwent open kidney stone surgery in Amir Al-Momenin hospital were evaluated. The investigated variables included gender, age, changes in blood pressure, postoperative complications, and duration of surgery. The information was collected from hospital records and entered into SPSS software for analysis.Results: In this study, 25 patients were studied, of whom 14 (56%) were females. The mean age of the patients was 37.84 ±17.15 years. The youngest and oldest patients were 1 and 66 years old, respectively. Twelve patients (48%) had staghorn stones, and the rest (13 patients) had other types of stones. Blood pressure remained unchanged in 80% of the patients while 12% developed hypertension. Postoperative fever and infection were observed in only 4% of the patients. The prevalence of staghorn stones in men and women were 45.5% and 50%, respectively. The difference was not statistically significant (P = 0.821).Conclusion: The present study showed that the most common stones leading to open kidney surgery were of the staghorn type. Males were more likely to undergo open kidney surgery than females.