The effects of pro-, pre- and synbiotics supplementation on polycystic ovary syndrome: an umbrella review of meta-analyses of randomized controlled trials

Abstract

Background Numerous meta-analyses of randomized clinical trials have proven that pro, pre- and synbiotics supplementation have numerous health outcomes in women with polycystic ovary syndrome (PCOS). However, the strength and quality of this evidence in aggregate not yet been synthesized in great detail. Methods PubMed, Scopus, Web of Sciences, and Google Scholar were searched up to August 2022. We pooled the mean difference and its 95% confidence interval (CI) by applying a random-effects model. Results Overall, eight meta-analyses including a total of 12 trials were identified. The results of the present study indicated that probiotic supplementation significantly reduced the homeostatic model assessment for insulin resistance (HOMA-IR) (WMD: -0.29, 95% CI: -0.57 to -0.02, P = 0.03, n = 4; moderate certainty) and fasting glucose concentration (WMD: -7.5 mg/dl, 95% CI: -13.60 to -0.51, P = 0.03; n = 4; low certainty). Moreover, synbiotic supplementation had beneficial effects on glycemic control, lipid profile, and hormonal parameters, but the certainty of the evidence was rated as low to very low. However, supplementation with pro-/synbiotics did not affect inflammation and oxidative stress in women with PCOS. Furthermore, waist/hip circumference, fasting glucose concentration, lipid profile, dehydroepiandrosterone sulfate, high-sensitivity C-reactive protein, and hirsutism score were significantly reduced after prebiotics supplementation with low certainty of evidence. Conclusions Although pro-, pre- and synbiotics supplementation had beneficial effects on some PCOS-related outcomes, the certainty of the evidence was rated as low to very low. Therefore, further well-designed RCTs might help to confirm our findings in women with PCOS.

The modern pathogenetic challenges of polycystic ovary syndrome

“…The results of 9 meta-analysis researches demonstrated that additional probiotic use leads to significant decrease of HOMA-IR (p=0.03, moderate certainty) and fasting glucose concentration (p=0.03, low certainty). Also, positive results of certainly low or very low evidence for probiotic supplements was found for glycemic control, lipid profile, hormonal levels, waist/hip circumference, fasting glucose concentration, dehydroepiandrosterone sulfate concentration, high-sensitivity C-reactive protein, and hirsutism score [74]. On the other hand, PCOS influence negatively on gut microbiota functions and in a such way can impairment the disease course [75].…”

Comparative analysis of pectin and prebiotics on human microbiota modulation in early life stages and adults

“…29 In summary, the prebiotics showed a protective effect in these diseases, reducing inflammatory markers, increasing the production of SCFA, improving calcium absorption, improving immune and cognitive function, and increasing the abundance of Bifidobacterium, amongst other beneficial effects. 29 Other recent systematic reviews and meta-analyses evaluated the effect of prebiotic supplementation for diabetes, [109][110][111] intestinal infections, 112,113 respiratory infections, 114 thyroid function, 115,116 depression, 117,118 autism, 119,120 polycystic ovary syndrome, 121 and non-alcoholic fatty liver disease (NAFLD). 122,123 V. Comparative analysis Age-dependent variations in the composition of gut microbiota 1.…”