The effects of progesterone treatment on nuchal translucency in women with threatened miscarriage

Karadağ, Cihan; Yoldemir, Tevfik; Demircan, Sinem; Çalışkan, Eray

doi:10.1080/01443615.2020.1787361

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…If the thickness of the NT is affected by the use of exogenous progesterone, then the false-positive detection rate for Down syndrome screening tests increases. The use of oral progesterone does not alter NT thickness due to the threat of miscarriage [21]. Matilainen et al also reported that PAPP-A was not signi cantly different between the groups receiving and non-receiving exogenous progesterone, which were consistent with the results of our study.…”

Section: Discussionsupporting

confidence: 92%

The relationship between exogenous progesterone administration in the first- trimester pregnancy and fetal nuchal translucency thickness

Mahmoodian

Zare

Seydoshohadaei

et al. 2022

Preprint

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Introduction: Increased fetal nuchal translucency (NT) thickness is defined as a transient subcutaneous accumulation of fluid behind the fetal neck that can be seen with the help of ultrasound. The thickness of fetal NT is a diagnostic criterion in genetic syndromes. The aim of this study was to investigate the relationship between exogenous progesterone administration in the first trimester of pregnancy and fetal NT thickness.Materials and Methods: This retrospective cohort study was conducted on 200 pregnant women aged 18 to 45 years including 100 pregnant women receiving exogenous progesterone due to vaginal bleeding in the first trimester and 100 pregnant women who did not receive exogenous progesterone from February 2021 to November 2021. The NT thickness of their fetal was measured at 11 to 12 weeks-6 days of gestation. Data were analyzed using Stata software version 14 using independent t-test, Chi-square, Fisher, and Pearson correlation coefficient. The statistical significance level was determined as less than 0.05 (P <0.05).Results: Mean of age, body mass index (BMI), gestational age (GA), crown-rump length (CRL), pregnancy-associated plasma protein-A (PAPP-A), free beta-human chorionic gonadotropin (FβHCG) and βHCG median and multiple of median (MOM) levels were not statistically significant in the two groups (p<0.05).The mean of NT thickness in the group receiving exogenous progesterone was higher than the group non-receiving exogenous progesterone and there was a significant difference between the two groups (p<0.05). Frequency distribution of Gravida, parity, previous live births, previous abortion, and history of abnormalities were not significant in the two groups (p<0.05). Conclusion: Although the findings of the present study showed that external progesterone consumption increased the thickness of the fetal nuchal translucency thickness, no anomaly was observed in delivered babies.

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Section: Discussionsupporting

confidence: 92%

The relationship between exogenous progesterone administration in the first- trimester pregnancy and fetal nuchal translucency thickness

Mahmoodian

Zare

Seydoshohadaei

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Threatened abortion is common in obstetrics and gynecology, the etiology of which is complex and related to various factors such as maternal genetics, corpus luteum function, endocrine disorders, and environmental inducements [ 11 ]. It mostly occurs in early pregnancy and is closely related to luteal insufficiency, accounting for about 30% of spontaneous abortions [ 12 ]. Western medicine mostly uses progesterone supplementation to treat pregnant women with threatened abortion.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dydrogesterone Tablets Combined with Zishen Yutai Pills on Threatened Abortion in Early Pregnancy and Pregnancy Outcomes

Chen¹,

Qiu

Jin³

2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the effect of dydrogesterone tablets combined with Zishen Yutai pills on threatened abortion in early pregnancy and pregnancy outcomes. Methods. This study retrospectively analyzed the clinical data of 100 patients with threatened abortion in early pregnancy who came to the Linhai Second People’s Hospital/Taizhou Municipal Hospital from January 13, 2021, to January 13, 2022. According to different treatment methods, 48 patients treated with progesterone injection were assigned to the control group (CG), while 52 cases with the combined therapy of dydrogesterone tablets and Zishen Yutai pills were assigned to the observation group (OG). The two groups were compared in terms of the following parameters: treatment efficacy, whole blood high shear viscosity, hematocrit (HCT), plasma fibrinogen (FIB) level, spiral artery pulsatility index (PI), uterine spiral artery blood flow resistance index (RI), lumbar and abdominal pain relief time, hemostasis time, estrogen levels, pregnancy outcomes, neonatal adverse outcomes, and incidence of adverse reactions. Results. Compared with CG, the therapeutic effect in OG was observed to be evidently better, and its pain relief time and hemostasis time in the waist and abdomen were markedly shorter. After treatment, the whole blood high shear viscosity, FIB, RI, PI, and estrogen levels of both groups improved statistically compared with those before treatment, with more significant improvements in OG compared with CG. OG was also superior to CG with markedly lower incidence of preterm birth, miscarriage, neonatal adverse outcomes, and adverse reactions and a drastically higher full-term pregnancy rate. Conclusion. Zishen Yutai pill combined with dydrogesterone tablets is of remarkable therapeutic effect in treatment of early threatened abortion, which can significantly improve clinical symptoms and pregnancy outcomes of patients, with a high safety profile, which is worthy of clinical application.

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“…The second study examined the effect of vaginal progesterone treatment on screening tests in the group of women who became pregnant using assisted reproductive technology (27). In the study by Karadağ et al there was no statistical difference in NT thickness, PAPP-A, and βhCG levels between the groups that received progesterone and those that did not (28).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of The Effects of Different Progesterone Treatment Methods on Fetal Aneuploidy Screening Tests

İbanoğlu

Kose

KACAN>

et al. 2023

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

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Objective In this study, the effect of progesterone use on biomarkers due to abortion complaints in aneuploidy screenings was investigated. Study Design Two hundred seventy-six singleton pregnant patients with threatened abortion were enrolled in this retrospective study. The treatment group consisted of patients who received oral, vaginal, or intramuscular progesterone (n=137) while the control group received no progesterone (n=139). The results of the double and triple screening tests of the study groups were compared. Results Nuchal translucency measurements and pregnancy-associated plasma protein-A (PAPP-A), (MoM) values were significantly lower in the group that received treatment with progesterone compared to the control group (p=0.009 and p

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The effects of progesterone treatment on nuchal translucency in women with threatened miscarriage

Cited by 6 publications

References 20 publications

The relationship between exogenous progesterone administration in the first- trimester pregnancy and fetal nuchal translucency thickness

The relationship between exogenous progesterone administration in the first- trimester pregnancy and fetal nuchal translucency thickness

Effects of Dydrogesterone Tablets Combined with Zishen Yutai Pills on Threatened Abortion in Early Pregnancy and Pregnancy Outcomes

Evaluation of The Effects of Different Progesterone Treatment Methods on Fetal Aneuploidy Screening Tests

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