The effects of propolis on doxorubicin-induced hepatorenal damage: a comparison of ethanolic and oily extracts of propolis

Cirrik, Selma; Kabartan Cokelİ, Emel; Gulec Peker, Emine Gulceri; Hacioglu, Gulay

doi:10.1080/19476337.2023.2274370

CyTA - Journal of Food

2023

DOI: 10.1080/19476337.2023.2274370

|View full text |Cite

The effects of propolis on doxorubicin-induced hepatorenal damage: a comparison of ethanolic and oily extracts of propolis

Selma Cirrik,

Emel Kabartan Cokelİ,

Emine Gulceri Gulec Peker

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Mitigating Chemotherapy Side Effects: The Role of Prunus laurocerasus in Protecting Spermatogenesis

Kabartan Çökeli,

Cırrık,

Güleç Peker

et al. 2024

International Journal of Traditional and Complementary Medicine Research

View full text Add to dashboard Cite

Objective: Chemotherapy treatments for cancer often lead to reproductive toxicity. This study aims to investigate the potential antioxidant effects of Prunus laurocerasus in reducing oxidative stress caused by the anticancer drug Doxorubicin (DOX) during chemotherapy, with a specific focus on preserving sperm production. Material-Method: Rats received varying doses of PLFE daily for two weeks, with a single administration of DOX given on the 13th day. Control groups included rats with no treatment, while damage groups were given only DOX. We assessed the protective effects of high (HD) and low (LD) doses of PLFE against DOX-induced damage by analyzing sperm parameters and antioxidant levels in testicular tissue. Results: Results showed that the DOX-only group had significantly higher Malondialdehyde (MDA), and dead sperm ratio also lower sperm count, and motility. Glutathione (GSH) level, Superoxide dismutase (SOD) activity and Catalase (CAT) activity, showed a decrease compared to all other groups. PLFE adjusted these parameters closer to the control values, but not the same as the control group. MDA levels and CAT activities decreased inversely, while SOD activities and GSH levels increased with higher doses. Conclusion: P. laurocerasus and its active compounds could be targets for developing treatments to preserve fertility and improve reproductive success post-chemotherapy. Further investigations are crucial for determining the optimal application duration and dosage, and to thoroughly understand the mechanism of action.

show abstract

Mitigating Chemotherapy Side Effects: The Role of Prunus laurocerasus in Protecting Spermatogenesis

Kabartan Çökeli,

Cırrık,

Güleç Peker

et al. 2024

International Journal of Traditional and Complementary Medicine Research

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The effects of propolis on doxorubicin-induced hepatorenal damage: a comparison of ethanolic and oily extracts of propolis

Cited by 1 publication

References 33 publications

Mitigating Chemotherapy Side Effects: The Role of Prunus laurocerasus in Protecting Spermatogenesis

Mitigating Chemotherapy Side Effects: The Role of Prunus laurocerasus in Protecting Spermatogenesis

Contact Info

Product

Resources

About