The effects of pyruvate supplementation on body composition in overweight individuals

Kalman, Douglas; Colker, Carlon M.; Wilets, Ilene; Roufs, J.; António, José

doi:10.1016/s0899-9007(99)00034-9

Cited by 66 publications

(43 citation statements)

References 11 publications

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“…32) Both glycine and alanine can readily be metabolized to pyruvate, which has been reported to have an anti-obesity effect. 33,34) Thus it is of interest to test whether high levels of glycine and alanine are responsible for the anti-obese effect of PLH. Further studies are necessary to clarify the relationship between dietary amino acid composition and fat accumulation.…”

Section: Discussionmentioning

confidence: 99%

Consumption of Pork-Liver Protein Hydrolysate Reduces Body Fat in Otsuka Long-Evans Tokushima Fatty Rats by Suppressing Hepatic Lipogenesis

Shimizu

Tanabe

Morimatsu

et al. 2006

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

Consumption of Pork-Liver Protein Hydrolysate Reduces Body Fat in Otsuka Long-Evans Tokushima Fatty Rats by Suppressing Hepatic Lipogenesis

Shimizu

Tanabe

Morimatsu

et al. 2006

Bioscience, Biotechnology, and Biochemistry

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“…Besides being a precursor, pyruvic acid is also directly utilized. For example, there have been reports on its use as a dietary supplement for weight loss enhancements (156), positive effects in acne treatment (27), and a variety of cardioprotective outcomes (215). The PDC-negative pdc1⌬ pdc5⌬ pdc6⌬ strain mentioned above represents an interesting platform for microbial production of pyruvate since it accumulates high levels of this compound.…”

mentioning

confidence: 99%

Progress in Metabolic Engineering of Saccharomyces cerevisiae

Nevoigt

2008

Microbiol Mol Biol Rev

528

333

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SUMMARY The traditional use of the yeast Saccharomyces cerevisiae in alcoholic fermentation has, over time, resulted in substantial accumulated knowledge concerning genetics, physiology, and biochemistry as well as genetic engineering and fermentation technologies. S. cerevisiae has become a platform organism for developing metabolic engineering strategies, methods, and tools. The current review discusses the relevance of several engineering strategies, such as rational and inverse metabolic engineering, evolutionary engineering, and global transcription machinery engineering, in yeast strain improvement. It also summarizes existing tools for fine-tuning and regulating enzyme activities and thus metabolic pathways. Recent examples of yeast metabolic engineering for food, beverage, and industrial biotechnology (bioethanol and bulk and fine chemicals) follow. S. cerevisiae currently enjoys increasing popularity as a production organism in industrial (“white”) biotechnology due to its inherent tolerance of low pH values and high ethanol and inhibitor concentrations and its ability to grow anaerobically. Attention is paid to utilizing lignocellulosic biomass as a potential substrate.

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“…49,50 Two double-blind RCTs, which included patients with a BMI of 25 kg/m 2 and above were identified. 51,52 None of the studies reported significantly greater effects for body weight reduction compared with placebo. One 51 reported a significant body weight reduction of 1.2 kg from baseline, while both report significant reductions of fat mass and percentage body fat from baseline.…”

Section: Pyruvatementioning

confidence: 94%

Complementary therapies for reducing body weight: a systematic review

2005

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The prevalence of obesity is increasing at an alarming rate and a plethora of complementary therapies are on offer claiming effectiveness for reducing body weight. The aim of this systematic review is to critically assess the evidence from randomized controlled trials (RCTs) and systematic reviews of complementary therapies for reducing body weight. Literature searches were conducted on Medline, Embase, Amed, and the Cochrane Library until January 2004. Hand-searches of relevant medical journals and bibliographies of identified articles were conducted. There were no restrictions regarding the language of publication. Trial selection, quality assessment and data abstraction were performed systematically and independently by two authors. Data from RCTs and systematic reviews, which based their findings on the results of RCTs, were included. Six systematic reviews and 25 additional RCTs met our inclusion criteria and were reviewed. The evidence related to acupuncture, acupressure, dietary supplements, homeopathy and hypnotherapy. Except for hypnotherapy, Ephedra sinica and other ephedrine-containing dietary supplements the weight of the evidence is not convincing enough to suggest effectiveness. For these interventions, small effects compared with placebo were identified. In conclusion, our findings suggest that for most complementary therapies, the weight of the evidence for reducing body is not convincing. Hypnotherapy, E. sinica and other ephedrine-containing dietary supplements may lead to small reductions in body weight. However, the intake of E. sinica and ephedrine is associated with an increased risk of adverse events. Interventions suggesting positive effects in single RCTs require independent replication.

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The effects of pyruvate supplementation on body composition in overweight individuals

Cited by 66 publications

References 11 publications

Consumption of Pork-Liver Protein Hydrolysate Reduces Body Fat in Otsuka Long-Evans Tokushima Fatty Rats by Suppressing Hepatic Lipogenesis

Consumption of Pork-Liver Protein Hydrolysate Reduces Body Fat in Otsuka Long-Evans Tokushima Fatty Rats by Suppressing Hepatic Lipogenesis

Progress in Metabolic Engineering of Saccharomyces cerevisiae

Complementary therapies for reducing body weight: a systematic review

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