The effects of QMix and EndoActivator on postoperative pain in mandibular molars with nonvital pulps: a randomized clinical trial

Yılmaz, Koray; Tüfenkçi, Pelin; Adıgüzel, Mehmet

doi:10.1007/s00784-019-02856-6

Cited by 18 publications

(16 citation statements)

References 26 publications

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“…QMix causes death in cells because of its contents. [17,18] CHX in contact with the tissue will bind to the plasma membrane of cells, causing membrane permeability to increase, and this results in an increase in the amount of intracellular Ca 2+ . This causes leakage of the lysosomal enzymes that have potential for cell death, such as phospholipase (membrane damage), proteases (membrane damage and cytoskeletal proteins), endonuclease (breakdown of DNA and chromatin), and ATPase, also defined as F1FO-ATP synthase or Complex V, is located in the inner mitochondrial membrane together with the ETC Complexes I-IV (accelerates the reduction of oxygen).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity assay of sodium hypochlorite and QMix on cultured human periodontal ligament fibroblast cells

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity assay of sodium hypochlorite and QMix on cultured human periodontal ligament fibroblast cells

et al. 2019

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“…Visual Analogue Scale/Score (VAS), ranging from 0 to 10 (0, no pain; 1 to 3, mild pain [sustainable, sleep is not affected], 4 to 6, moderate pain [sleep is affected and painkillers are usually needed], 7 to 10, severe pain [Sleep is severely disrupted and painkillers are necessary]), was applied to evaluate the pain degree of postoperative patients [15]. In this study, the pain was de ned as greater than 3 on the scale, considered to potentially affect emotional or physical functioning [16].…”

Section: Methods Patientsmentioning

confidence: 99%

Effect and Safety of Intraoperative Intraperitoneal Chemotherapy on Patients Suffering From Colorectal Cancer.

Shang

Wang

Yang

et al. 2021

Preprint

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BackgroundColorectal cancer (CRC), the third most commonly diagnosed malignant neoplasm and the third most common cause of carcinoma-related mortality, continues to be a major international health problem. And approximately 33% of patients suffer from recurrence after radical surgery. Free malignant cells implanting in the peritoneum is generally accepted for present purposes. We did the study with the aim of evaluating the effects and safety of Intraoperative intraperitoneal chemotherapy (IOC) on patients suffering from colorectal cancer.MethodsIn total, 357 patients who went through colorectal radical surgery were considered eligible between September 23rd, 2017 to December 31st, 2018. 179 patients were treated with surgery alone, and 178 patients received surgery plus IOC. Clinical characteristics, operative findings, postoperative short-term outcomes and Disease- Free survival (DFS) were compared between the 2 groups in the selected population.ResultThe present research involves 357 patients (224 men and 133 women) who underwent surgery alone (n = 179) or surgery plus IOC (n = 178), with a mean (SD) age of 61.9 (10.4) years in the surgery alone group and 61.9 (9.1) in the surgery plus IOC group (P = .52). No significant differences were witnessed between the two groups in surgery-related information and postoperative complications. In patients with stage II colorectal cancer, the Disease- Free 1, 2and 3 years survival rates of surgery alone group were 98%, 91% and 86% respectively; and 96%, 94% and 81% respectively for surgery combined with IOC group (P = .82, Kaplan-Meier log-rank). In stage Ⅲ CRC patients, the survival rate analysis (Kaplan-Meier) showed a 82%, 68% and 61% Disease- Free survival of surgery alone group and a 94%, 85% and 82% of surgery plus IOC group after 1, 2 and 3 years, respectively (P = .002, Kaplan-Meier log rank).ConclusionsIn the present study, we have found that surgery plus IOC generated a favorable prognosis for stage Ⅲ CRC patients but not stage Ⅱ without any side-effects when the dosage of lobaplatin was 0.1 g/L. As a new, safe, and simple procedure, IOC therapy is easily performed anywhere and does not require any special devices or techniques. Thus, IOC is a promising and exciting therapeutic strategy for patients with CRC.

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“…Other studies [ 76 77 ] made an effort to standardize the irrigant volume and duration, with results showing no significant difference between manual and sonic irrigation, although the latter resulted in significantly less pain than MDA and negative pressure irrigation. Sonics with QMix (an irrigant mixture of CHX and EDTA) resulted in significantly less pain than sonic or needle-and-syringe irrigation with 2.5% NaOCl [ 78 ].…”

Section: Post-operative Painmentioning

confidence: 99%

“…⋄ VAS score (1-4) at 4, 24 & 48 hours ⋄ Apical negative pressure (30 sec 1 mL 2.5% NaOCl; needle irrigation of 1 mL 2.5% NaOCl) Yilmaz et al [78] 2019 ⋄ Syringe needle irrigation (1 min 4 mL 2.5% NaOCl) ⋄ Sonic irrigation (1 min 4 mL 2.5% NaOCl of activation) ⋄ Syringe needle irrigation (1 min 4 mL 2.5% NaOCl; 3 mL sterile water; 1 min 3 mL QMix) ⋄ Sonic irrigation (1 min 4 mL 2.5% NaOCl of activation; 3 mL sterile water; 1 min 3 mL QMix of activation) significantly more analgesics at 0 to 24 hours [75]. However, in that study, sonic irrigation was used for a longer time than syringe irrigation.…”

Section: Sonic Irrigationmentioning

confidence: 99%

Clinical efficacy of activated irrigation in endodontics: a focused review

2021

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Root canal debridement, which includes the removal of infected tissues and microbial biofilms, is considered the corner stone of root canal treatment. Chemical adjuncts play a multitude of functions in this regard, as tissue solvents, antimicrobial agents and for removing the smear layer. These adjuncts (irrigants) are usually delivered using a syringe and needle. With increasing knowledge of the complexity of root canal anatomy and tenacity of microbial biofilms, the need for strategies that potentiate the action of these irrigants within the root canal system cannot be overemphasized. Several such activated irrigation strategies exist. The aim of this review is to comprehensively discuss the different irrigant activation methods from the context of clinical studies.

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The effects of QMix and EndoActivator on postoperative pain in mandibular molars with nonvital pulps: a randomized clinical trial

Cited by 18 publications

References 26 publications

Cytotoxicity assay of sodium hypochlorite and QMix on cultured human periodontal ligament fibroblast cells

Cytotoxicity assay of sodium hypochlorite and QMix on cultured human periodontal ligament fibroblast cells

Effect and Safety of Intraoperative Intraperitoneal Chemotherapy on Patients Suffering From Colorectal Cancer.

Clinical efficacy of activated irrigation in endodontics: a focused review

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