The effects of race/ethnicity and sex on the risk of venous thromboembolism

Keenan, Craig R; White, Richard

doi:10.1097/mcp.0b013e3281eb8ef0

Cited by 75 publications

(61 citation statements)

References 34 publications

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“…This is in concordance with previously published studies and population-based data [10,29]. The lower incidence of PE among Asians and Pacific Islanders (which are categorised under "other" in our study), has been attributed to a lower prevalence of factor V Leiden and other genetic predisposing factors [22].…”

Section: Discussionsupporting

confidence: 82%

Risk factors for pulmonary embolism after hip and knee arthroplasty: a population-based study

Memtsoudis

Besculides

Gaber³

et al. 2008

International Orthopaedics (SICOT)

111

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Section: Discussionsupporting

confidence: 82%

Risk factors for pulmonary embolism after hip and knee arthroplasty: a population-based study

Memtsoudis

Besculides

Gaber³

et al. 2008

International Orthopaedics (SICOT)

111

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“…This situation necessitates the generation of several appropriate age-dependent reference ranges to interpret laboratory data in pediatric patients and prevent misclassification of children having defects of factors and inhibitors of the coagulation system (7). Since there are differences in the hemostatic system among different racial/ethnic groups (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27), and also between different analyzer and reagent systems (4), coagulation laboratories should develop age-related reference ranges specific to their own testing systems for the local population (4,7,32). In this study, we analyzed retrospectively the results of preoperative APTT testing in childhood and adult controls undergoing minor elective surgery.…”

Section: Discussionmentioning

confidence: 99%

“…For example, the incidence and risk of venous thromboembolism (VTE) is markedly lower in Asian/Pacific Islanders than in Caucasians and African Americans (10)(11)(12)(13)(14). VTE is not as common in Chinese as in Caucasians (15).…”

Section: Introductionmentioning

confidence: 99%

Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children

Lai

Yan

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…However, when compared with Whites, Black-Americans appear to have a higher risk for [5,6] and incidence of VTE [7][8][9][10]. Two single-nucleotide polymorphisms, factor V Leiden (G1691A) and prothrombin G20210A, have been identified as risk factors for deep vein thrombosis (DVT) and pulmonary embolism (PE) in Europeans and White-Americans, [11][12][13][14][15][16] but not Black-Americans [6,17,18].…”

Section: Introductionmentioning

confidence: 99%

Comparison of characteristics from White‐ and Black‐Americans with venous thromboembolism: A cross‐sectional study

et al. 2010

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When compared with Whites, Black-Americans may have a 40% higher incidence venous thromboembolism (VTE) incidence. However, whether other VTE characteristics and risk factors vary by race is uncertain. To compare demographic and baseline characteristics among White-and Black-Americans with VTE, we used data prospectively collected from consecutive consenting adults enrolled in seven Centers for Disease Control (CDC) Thrombosis and Hemostasis Centers from August 2003 to March 2009. These characteristics were compared among Whites (n 5 2002) and Blacks (n 5 395) with objectively diagnosed VTE, both overall, and by age and gender. When compared with Whites, Blacks had a significantly higher proportion with pulmonary embolism (PE), including idiopathic PE among Black women, and a significantly higher proportion of Blacks were women. Blacks had a significantly higher mean BMI and a significantly lower proportion with recent surgery, trauma or infection, family history of VTE, and documented thrombophilia (solely from reduced factor V Leiden and prothrombin G20210A prevalence). Conversely, Blacks had a significantly higher proportion with hypertension, diabetes mellitus, chronic renal disease and dialysis, HIV, and sickle cell disease. When compared with White women, Black women had a significantly lower proportion with recent oral contraceptive use or hormone therapy. We conclude that Whites and Blacks differ significantly regarding demographic and baseline characteristics that may be risk factors for VTE. The prevalence of transient VTE risk factors and idiopathic VTE among Blacks appears to be lower and higher, respectively, suggesting that heritability may be important in the etiology of VTE among Black-Americans. Am. J. Hematol. 85:467-471, 2010. V V C 2010 Wiley-Liss, Inc. IntroductionMost epidemiologic studies of venous thromboembolism (VTE) risk factors have been conducted within White-American and -European populations [1][2][3][4]. However, when compared with Whites, Black-Americans appear to have a higher risk for [5,6] and incidence of VTE [7][8][9][10]. Two single-nucleotide polymorphisms, factor V Leiden (G1691A) and prothrombin G20210A, have been identified as risk factors for deep vein thrombosis (DVT) and pulmonary embolism (PE) in Europeans and White-Americans, [11][12][13][14][15][16] but not Black-Americans [6,17,18]. We hypothesized that the apparent higher VTE incidence among Blacks might be due to an increased prevalence of known VTE risk factors. To test this hypothesis, we compared demographic and baseline clinical characteristics from White-and Black-Americans with objectively diagnosed VTE who were seen in one of the seven CDC Thrombosis and Hemostasis Research and Prevention Network centers.

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The effects of race/ethnicity and sex on the risk of venous thromboembolism

Abstract: Sex and race/ethnicity are important factors in the risk of first-time and recurrent venous thromboembolism and need to be included as risk assessment and diagnostic prediction tools are developed or updated.

Cited by 75 publications

References 34 publications

Risk factors for pulmonary embolism after hip and knee arthroplasty: a population-based study

Risk factors for pulmonary embolism after hip and knee arthroplasty: a population-based study

Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children

Comparison of characteristics from White‐ and Black‐Americans with venous thromboembolism: A cross‐sectional study

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