The Effects of Radioiodine Therapy on the Recovery of Parathyroid Function in Patients with Protracted Hypoparathyroidism after Total Thyroidectomy for Papillary Thyroid Carcinoma

Abuduwaili, Munire; Baidula, Wusiman; Xia, Baoying; Wu, Zhujuan; Chen, Ziwei; Xing, Zhichao; Su, Anping

doi:10.1080/08941939.2022.2146239

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Although central lymph node dissection is effective in reducing the risk of postoperative tumor recurrence, it is closely associated with recurrent laryngeal nerve, PG, and thyroid gland. Therefore, when the central lymph node lesions are completely removed, the possibility of PG damage will also be increased, thus resulting in postoperative adrenal dysfunction (8,9). Adrenal dysfunction is a typical postoperative disease, that can lead to hypocalcemia, manifested as perioral paralysis, quadriplegia, severe cases can occur quadriplegia and respiratory muscle spasm symptoms.…”

Section: Introductionmentioning

confidence: 99%

Correlation between parathyroid function and serum levels of 1,25(OH)2D3, serum phosphorus, and parathyroid hormone after surgery for papillary thyroid carcinoma

Bo Wang,

Lei Gu,

Jun Liu

2023

Cell Mol Biol (Noisy-le-grand)

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Section: Introductionmentioning

confidence: 99%

Correlation between parathyroid function and serum levels of 1,25(OH)2D3, serum phosphorus, and parathyroid hormone after surgery for papillary thyroid carcinoma

Bo Wang,

Lei Gu,

Jun Liu

2023

Cell Mol Biol (Noisy-le-grand)

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Advances in the selection and timing of postoperative radioiodine treatment in patients with differentiated thyroid carcinoma

Dai,

Ren,

Zhang

et al. 2024

Ann Nucl Med

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Risk and Protective Factors of Postoperative and Persistent Hypoparathyroidism after Total Thyroidectomy in a Series of 1965 Patients

Dughiero,

Torresan,

Censi

et al. 2024

Cancers

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Background: Postoperative hypoparathyroidism (HypoPTH) is the most common complication following total thyroidectomy. Several risk factors have been identified, but data on postoperative follow-up are scarce. Methods: The study focused on 1965 patients undergoing surgery for benign and malignant thyroid diseases at a tertiary-level academic center. Anamnestic, biochemical, surgical, pathological, and follow-up data were evaluated. HypoPTH was defined by a serum concentration of PTH < 10 pg/mL on the first or the second post-operative day. Persistent HypoPTH was defined by the need for calcium/active vitamin D treatment > 12 months after surgery. Results: Postoperative HypoPTH occurred in 542 patients. Multivariate analysis identified the association of central lymph-nodal dissection, reduced preoperative PTH levels, a lower rate of parathyroid glands preserved in situ, and longer duration of surgery as independent risk factors. At a median follow-up of 47 months, HypoPTH regressed in 443 patients (more than 6 months after surgery in 7%) and persisted in 53 patients. Patients receiving a lower dose of calcium/active vitamin D treatment at discharge (HR 0.559; p < 0.001) or undergoing prolonged, tailored, and direct follow-up by the operating endocrine surgeon team had a significantly lower risk of persistent HypoPTH (2.4% compared to 32.8% for other specialists) (HR 2.563; p < 0.001). Conclusions: Various patient, disease, and surgeon-related risk factors may predict postoperative HypoPTH. Lower postoperative calcium/active vitamin D treatment and prolonged, tailored follow-up directly performed by operating endocrine surgeons may significantly reduce the rate of persistent HypoPTH.

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The Effects of Radioiodine Therapy on the Recovery of Parathyroid Function in Patients with Protracted Hypoparathyroidism after Total Thyroidectomy for Papillary Thyroid Carcinoma

Cited by 4 publications

References 28 publications

Correlation between parathyroid function and serum levels of 1,25(OH)2D3, serum phosphorus, and parathyroid hormone after surgery for papillary thyroid carcinoma

Correlation between parathyroid function and serum levels of 1,25(OH)2D3, serum phosphorus, and parathyroid hormone after surgery for papillary thyroid carcinoma

Advances in the selection and timing of postoperative radioiodine treatment in patients with differentiated thyroid carcinoma

Risk and Protective Factors of Postoperative and Persistent Hypoparathyroidism after Total Thyroidectomy in a Series of 1965 Patients

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