The effects of ranitidine on pituitary‐thyroid function.

Kr, Hine; Harrop, J. S.; Hopton,; Gk, Holmes; Matthews, HL

doi:10.1111/j.1365-2125.1984.tb02512.x

Brit J Clinical Pharma

1984

DOI: 10.1111/j.1365-2125.1984.tb02512.x

|View full text |Cite

The effects of ranitidine on pituitary‐thyroid function.

Hine Kr¹,

J. S. Harrop²,

Hopton Hopton³

et al.

Abstract: Although several studies have examined the effects of cimetidine on pituitary-thyroid function, few have investigated ranitidine in this respect. We found no changes in thyroid-stimulating-hormone (TSH) or prolactin responses to TSH-releasing-hormone (TRH) in 10 patients with peptic ulcer disease given oral ranitidine. Serum total and free thyroxine (Ti4 and FT4) concentrations declined slightly, whereas total and free triiodothyronine (Ti3 and FIT3) increased slightly following ranitidine. None of these chang… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1986

2002

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 9 publications

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Adverse Reactions and Interactions with H2-Receptor Antagonists

Penston

Wormsley

1986

Medical Toxicology

View full text Add to dashboard Cite

Histamine H2-receptor antagonists have been used in the treatment of gastrointestinal diseases for more than a decade and during this period have become one of the most commonly prescribed groups of drugs in the world. The deserved popularity of the H2-receptor antagonists reflects, in part, their therapeutic efficacy, which has revolutionised the treatment of peptic ulcer disease. An equally, or more, important reason for the widespread use of H2-receptor antagonists is their remarkably low toxicity. We have attempted, in this review, to present a detailed account of the minor and more serious adverse reactions, while emphasising the low incidence of the former and the rarity of the latter. The toxicology of the H2-receptor antagonists is discussed under two main headings: adverse effects; and drug interactions. The latter category is potentially the more significant, since the frequent use of therapy with multiple drugs may give rise to drug interactions, some of which are serious and may even be lethal. These drug interactions occur especially in the gastrointestinal tract, the liver and the kidneys. Thus, the absorption of other drugs may be altered because the H2-receptor antagonists inhibit gastric secretion--an effect illustrated by ketoconazole, the absorption of which is reduced when given in combination with cimetidine. Very important drug interactions are caused by inhibition of the hepatic microsomal enzyme cytochrome P450 by some of the H2-receptor antagonists. This effect appears to be related to the chemical structure of the individual H2-receptor antagonists and is not attributable to histamine H2-receptor blockade. For example, cimetidine is a powerful inhibitor of cytochrome P450, while the interaction of ranitidine with this system is weaker. Consequently, cimetidine reduces the metabolism of many drugs which are normally degraded by phase I reactions, leading to potentially toxic plasma concentrations of therapeutic agents such as some oral anticoagulants, beta-blockers, anticonvulsants, benzodiazepines and xanthines. Some of the H2-receptor antagonists are actively secreted by the renal tubules and may thus compete with other drugs for cationic tubular transport mechanisms, resulting in reduced urinary excretion and hence potentially toxic plasma concentrations. This type of drug interaction has been reported after administration of both cimetidine and ranitidine with procainamide or quinidine.(ABSTRACT TRUNCATED AT 400 WORDS)

show abstract

Adverse Reactions and Interactions with H2-Receptor Antagonists

Penston

Wormsley

1986

Medical Toxicology

View full text Add to dashboard Cite

show abstract

Farmaci che interferiscono con la funzione tiroidea

Trimarchi

Benvenga

2002

L'Endocrinologo

View full text Add to dashboard Cite

Comparative toxicology of temelastine A novel H1 antagonist in dog, rat, and monkey

Poole¹

1990

Fundamental and Applied Toxicology

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The effects of ranitidine on pituitary‐thyroid function.

Cited by 9 publications

References 20 publications

Adverse Reactions and Interactions with H2-Receptor Antagonists

Adverse Reactions and Interactions with H2-Receptor Antagonists

Farmaci che interferiscono con la funzione tiroidea

Comparative toxicology of temelastine A novel H1 antagonist in dog, rat, and monkey

Contact Info

Product

Resources

About