The effects of reduced dietary protein level on amino acid transporters and mTOR signaling pathway in pigs

Wang, Dan; Wan, Xuebin; Peng, Jian; Xiong, Qi; Niu, Hongdan; Li, Huanan; Chai, Jin Choul; Jiang, Siwen

doi:10.1016/j.bbrc.2017.02.084

Cited by 21 publications

(18 citation statements)

References 28 publications

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“…In contrast, we observed that 13.5 and 17.5% CP had the highest and lowest SIDAA, respectively. Similar effects have been recently observed in pigs ( Wang et al., 2017 ). This observation raises the interesting possibility that LP diets may have elevated amino acid digestibility and/or reduced endogenous amino acid flow to compensate intestinal AA deficiency.…”

Section: Discussionsupporting

confidence: 90%

Effects of dietary protein levels and protease supplementation on growth performance, carcass traits, meat quality, and standardized ileal digestibility of amino acid in Pekin ducks fed a complex diet

Wang

Zhang

Zhang³

et al. 2020

Poultry Science

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This study aimed to investigate to the effects of dietary CP levels and protease supplementation on growth performance, carcass traits, meat quality, nutrients utilization, and standardized ileal digestibility of amino acid in Pekin ducks fed a complex diet. A total of 960 14-day-old male ducks were weighed and randomly allotted to a 2 × 5 factorial arrangement of 10 treatments with 6 replicate pens per treatment and 16 ducks per pen fed to 49 D of age. Experimental factors included five dietary CP levels ranging from 13.5 to 17.5% and with or without protease (200 mg/kg) supplementation. Between day 28 to 34, the digestible and metabolizable trials were performed. Significant CP × protease interactions ( P < 0.05) on breast meat yield, DM, energy and nitrogen utilization, as well as standardized ileal digestibility values of 7 amino acids were observed. Regardless of protease supplementation, ducks fed 13.5, 14.5, and 15.5% CP had a poorer ( P < 0.05) growth performance and breast meat yield than ducks fed with 16.5 and 17.5% CP. Ducks fed 13.5% CP had a positive effect ( P < 0.05) on meat quality, dietary DM, energy and nitrogen utilization as well as standardized ileal digestibility of amino acids. Protease supplementation increased ( P < 0.05) DM and phosphorus retention and decreased ( P < 0.05) shear force of breast meat, regardless of CP level; when CP = 14.5%, protease significantly increased ( P < 0.05) breast muscle yield. The optimal CP requirement without or with protease supplementation for BWG and FI were 17.02 or 16.53% and 16.64 or 16.75%, respectively, based on linear broken-line regression.

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Section: Discussionsupporting

confidence: 90%

Effects of dietary protein levels and protease supplementation on growth performance, carcass traits, meat quality, and standardized ileal digestibility of amino acid in Pekin ducks fed a complex diet

Wang

Zhang

Zhang³

et al. 2020

Poultry Science

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“…Although glucose and AA transporters have been investigated for more than 40 years, only a limited number of viable hypotheses have been presented to explain the underlying molecular mechanisms and metabolic interactions. For example, AA transporters are widely used as an index when studying cancers or designing medical technologies (151,152). Therefore, researchers need more information related to intrinsic quality if these AAs are to serve as potential regulated sites/targets in cancer therapies or when developing new drugs.…”

Section: Prospectsmentioning

confidence: 99%

Glucose and amino acid in enterocyte absorption metabolism and maturation

Chen

Yin

et al. 2018

Front Biosci

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“…Reducing N excretion in swine manure can be effectively accomplished by reducing dietary CP intake. However, reducing the protein concentration of diets, with no supplemental crystalline AA, decreases growth performance and meat and carcass quality [9] and inhibits the activity of the mammalian target of rapamycin (mTOR) and s6 kinase 1 (S6K1), leading to the restriction of protein synthesis [10]. In low-protein diets, the absorption of protein-bound amino acids may be reduced, resulting in impaired animal growth performance if the dietary protein content cannot be further reduced, although the environmental benefits of low-protein diets are significant, the economic benefits are not obvious.…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Crude Protein Levels on Fecal Crude Protein, Amino Acids Flow Amount, Fecal and Ileal Microbial Amino Acids Composition and Amino Acid Digestibility in Growing Pigs

Yang

Bumbie

et al. 2020

Animals

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The purpose of this experiment was to evaluate the effects of low protein corn-soybean meal-based diets on fecal CP, amino acid (AA) flow amount, AA digestibility and fecal and ileal microbial AA composition in growing pigs. Eighteen pigs (initial body weight = 30 ± 1.35) were randomly divided into three groups and fed with basal diets with CP levels of 12%, 15% and 18%, respectively. The Lys, Met + Cys, Thr and Trp level in the 12% CP and 15% CP groups is the same as 18% CP group by the addition of four crystalline Lys, Met + Cys, Thr and Trp to the diet. The results showed that with the decrease of dietary CP level from 18% to 12%, the fecal total nitrogen (N), CP and total AA (TAA) flow amount decreased linearly (p < 0.05). Dry matter (DM) digestibility, CP digestibility, TAA digestibility, essential amino acid (EAA) digestibility and non-essential amino acid (NEAA) digestibility increased linearly with the decrease of dietary CP concentration from 18% to 12%. Compared with 18% CP group, the flow amount of Asp, Ser, Glu, Gly, Tyr, Val, Leu and Phe in feces of pigs in the 15% CP group and 12% CP group decreased significantly, while the flow amount of Arg in the 15% CP group was lower than that in the 18% CP group and 12% CP group. The fecal microbial N and AA of the 15% CP group were higher than those of the 18% CP and 12% CP groups. Fecal TAA flow amount decreased linearly with the decrease of the dietary CP levels from 18% to 12%. Fecal TAA and NEAA flow amount also decreased linearly with the decrease of dietary CP level from 18% to 12%. Except for Glu, Gly, Met, Tyr, Thr and Phe, there were significant differences among the three groups in the composition of 17 kinds of AAs in fecal microorganisms. Among the 17 AA compositions of ileal microorganisms, except Tyr and Lys, the other AAs were significantly different among the three groups (p < 0.05)

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The effects of reduced dietary protein level on amino acid transporters and mTOR signaling pathway in pigs

Cited by 21 publications

References 28 publications

Effects of dietary protein levels and protease supplementation on growth performance, carcass traits, meat quality, and standardized ileal digestibility of amino acid in Pekin ducks fed a complex diet

Effects of dietary protein levels and protease supplementation on growth performance, carcass traits, meat quality, and standardized ileal digestibility of amino acid in Pekin ducks fed a complex diet

Glucose and amino acid in enterocyte absorption metabolism and maturation

Effects of Dietary Crude Protein Levels on Fecal Crude Protein, Amino Acids Flow Amount, Fecal and Ileal Microbial Amino Acids Composition and Amino Acid Digestibility in Growing Pigs

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