“…Importantly, American ginseng appears not to inhibit the cytochrome p450 system 28 and has not been found to impact the effects of tamoxifen, doxorubicin, cyclophosphamide, paclitaxel, 5-fluorouracil, and methotrexate, but was instead synergistic with these agents inhibiting growth in MCF-7 breast cancer cell lines. 29,30 Effectiveness Not Established or Effectiveness Unlikely-Numerous treatments, detailed in Figure 3, have insufficient evidence to recommend them for clinical practice in cancer patients during active treatments (Effectiveness Not Established) including Asian ginseng (Panex ginseng), 31 guarana, 32 and Inner power 33 (an amino acid, coenzyme Q10, Lcarnitine blend); and music therapy, 34 progressive muscle relaxation, [35][36][37] qigong, 38 reflexology, 39 tai chi 40,41 and yoga, 42,43 and laser moxibustion. 44 Also, detailed in Figure 2 are 2 supplements, coenzyme Q10 45 and L-carnitine 46 that have research that indicates they are likely ineffective for treating CRF during active cancer treatment (Effectiveness Unlikely).…”