The effects of regular aerobic exercise training on blood nitric oxide levels and oxidized LDL and the role of eNOS intron 4a/b polymorphism

Yol, Yeliz; Turgay, Faruk; Yigittürk, Oya; Aşikovali, Semih; Durmaz, Burak

doi:10.1016/j.bbadis.2020.165913

Cited by 6 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plasma TAC is modulated mainly by radical overload, and it can be considered as more representative of the in vivo balance between oxidizing species and antioxidants (Ghiselli et al, 2000). Several studies have shown that regular aerobic exercise with 75-80% heart rate reserve intensity for 4-6 weeks could improve total antioxidant capacity in young college students and male soccer athletes (Diaz et al, 2011;Yol et al, 2020). In our review, the pooled results showed that regular aerobic exercise significantly increased plasma antioxidant markers, including NO, TAC, and SOD levels.…”

Section: Summary Of Evidencementioning

confidence: 99%

The Effects of Aerobic Exercise on Oxidative Stress in Older Adults: A Systematic Review and Meta-Analysis

Lin

Wan

et al. 2021

Front. Physiol.

View full text Add to dashboard Cite

Background: Oxidative stress (OS) plays an important role in the progression of many aging-related diseases. Exercises can delay this kind of progress, but aerobic exercise is the most commonly used type of training among older adults; therefore, its influence needs to be further verified.Methods: A literature search was conducted in eight electronic databases, including Cochrane, EMBASE, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang Date, and SinoMed from their inception to April 2020. Methodological quality was assessed using Cochrane RoB tool v2.0 for individual studies, and RevMan 5.3 software was used to perform the meta-analysis.Results: The meta-analysis included 20 studies, involving 1,170 older adults. The results showed that regular aerobic exercise could reduce blood oxidant markers, including malondialdehyde (MDA; SMD=−1.80, 95% CI −2.46 to −1.14, p<0.001) and lipid peroxide (LPO; SMD=−1.12, 95% CI −2.03 to −0.22, p=0.02), and increase the levels of antioxidant factors, such as nitric oxide (NO; SMD=0.89, 95% CI 0.37–1.41, p<0.001), superoxide dismutase (SOD; SMD=0.63, 95% CI 0.25–1.01, p=0.001), and total antioxidant capacity (TAC; SMD=1.22, 95% CI 0.45–1.98, p=0.002), with clear statistical significance. It may also improve the levels of other OS markers, such as 8-OHdG, 8-isoPGF2, VE, and reduced glutathione/oxidized glutathione (GSH/GSSG).Conclusion: Regular aerobic exercise may have a positive effect on the OS levels of older adults by reducing some oxidant markers and increasing antioxidant marker levels.

show abstract

Section: Summary Of Evidencementioning

confidence: 99%

The Effects of Aerobic Exercise on Oxidative Stress in Older Adults: A Systematic Review and Meta-Analysis

Lin

Wan

et al. 2021

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…We have long known that exercise is beneficial for the prevention and treatment of atherosclerosis. In many clinical studies, exercise can improve lipid metabolism and prevent the oxidation of LDL, which drives the development of atherosclerosis [ 34 , 35 ]. Previous reports also found that exercise can increase eNOS protein expression and decrease superoxide generation to improve NO availability by increasing vascular shear stress, which is important for endothelial function in atherosclerosis [ 35 , 36 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…In many clinical studies, exercise can improve lipid metabolism and prevent the oxidation of LDL, which drives the development of atherosclerosis [ 34 , 35 ]. Previous reports also found that exercise can increase eNOS protein expression and decrease superoxide generation to improve NO availability by increasing vascular shear stress, which is important for endothelial function in atherosclerosis [ 35 , 36 , 37 , 38 ]. Nascimento et al reported that exercise training can stabilize atherosclerotic plaques by decreasing the activity of matrix metalloproteinases (MMPs), especially MMP9 [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels

Zong-ze

Zhang

et al. 2022

IJMS

View full text Add to dashboard Cite

Atherosclerosis, accompanied by inflammation and metabolic disorders, is the primary cause of clinical cardiovascular death. In recent years, unhealthy lifestyles (e.g., sedentary lifestyles) have contributed to a worldwide epidemic of atherosclerosis. Exercise is a known treatment of atherosclerosis, but the precise mechanisms are still unknown. Here, we show that 12 weeks of regular exercise training on a treadmill significantly decreased lipid accumulation and foam cell formation in ApoE−/− mice fed with a Western diet, which plays a critical role in the process of atherosclerosis. This was associated with an increase in β-hydroxybutyric acid (BHB) levels in the serum. We provide evidence that BHB treatment in vivo or in vitro increases the protein levels of cholesterol transporters, including ABCA1, ABCG1, and SR-BI, and is capable of reducing lipid accumulation. It also ameliorated autophagy in macrophages and atherosclerosis plaques, which play an important role in the step of cholesterol efflux. Altogether, an increase in serum BHB levels after regular exercise is an important mechanism of exercise inhibiting the development of atherosclerosis. This provides a novel treatment for atherosclerotic patients who are unable to undertake regular exercise for whatever reason. They will gain a benefit from receiving additional BHB.

show abstract

“…On the one hand, aerobic exercise can reduce the content of free radicals and lipid peroxidation products in the blood, muscle, liver, and other tissues and organs after exercise, and reduce the degree of damage caused by free radicals by blocking the chain reaction of lipid peroxidation, reducing lipid peroxidation damage, and inhibiting lipid peroxidation production. On the other hand, aerobic exercise decreases the basal production of free radicals when the body is at rest, and reduces the peak value of free radicals during exercise [ 84 ]. After aerobic exercise intervention, the level of 3-NT in the EI group was significantly lower than that in the CFS group ( Figure 1 ).…”

Section: Discussionmentioning

confidence: 99%

Differential Metabolites and Metabolic Pathways Involved in Aerobic Exercise Improvement of Chronic Fatigue Symptoms in Adolescents Based on Gas Chromatography–Mass Spectrometry

Zhao

Chi

Wan

et al. 2022

IJERPH

View full text Add to dashboard Cite

Studies have found that the prevalence of chronic fatigue syndrome (CFS) in adolescents has continued to increase over the years, affecting learning and physical health. High school is a critical stage for adolescents to grow and mature. There are inadequate detection and rehabilitation methods for CFS due to an insufficient understanding of the physiological mechanisms of CFS. The purpose of this study was to evaluate the effect and metabolic mechanisms of an aerobic running intervention program for high school students with CFS. Forty-six male high school students with CFS were randomly assigned to the exercise intervention group (EI) and control group (CFS). Twenty-four age- and sex-matched healthy male students were recruited as healthy controls (HCs). The EI group received the aerobic intervention for 12 weeks, three times a week, in 45-min sessions; the CFS group maintained their daily routines as normal. The outcome measures included fatigue symptoms and oxidation levels. Keratin was extracted from the nails of all participants, and the oxidation level was assessed by measuring the content of 3-Nitrotyrosine (3-NT) in the keratin by ultraviolet spectrophotometry. All participants’ morning urine was collected to analyze urinary differential metabolites by the GC-MS technique before and after the intervention, and MetaboAnalyst 5.0 was used for pathway analysis. Compared with before the intervention, the fatigue score and 3-NT level in the EI group were significantly decreased after the intervention. The CFS group was screened for 20 differential metabolites involving the disruption of six metabolic pathways, including arginine biosynthesis, glycerolipid metabolism, pentose phosphate pathway, purine metabolism, β-alanine metabolism, and arginine and proline metabolism. After the intervention, 21 differential metabolites were screened, involved in alterations in three metabolic pathways: beta-alanine metabolism, pentose phosphate metabolism, and arginine and proline metabolism. Aerobic exercise was found to lessen fatigue symptoms and oxidative levels in students with CFS, which may be related to the regulation of putrescine (arginine and proline metabolism), 6-Phospho-D-Gluconate (starch and sucrose metabolism pathway), and Pentose (phosphate metabolism pathway).

show abstract

The effects of regular aerobic exercise training on blood nitric oxide levels and oxidized LDL and the role of eNOS intron 4a/b polymorphism

Cited by 6 publications

References 33 publications

The Effects of Aerobic Exercise on Oxidative Stress in Older Adults: A Systematic Review and Meta-Analysis

The Effects of Aerobic Exercise on Oxidative Stress in Older Adults: A Systematic Review and Meta-Analysis

Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels

Differential Metabolites and Metabolic Pathways Involved in Aerobic Exercise Improvement of Chronic Fatigue Symptoms in Adolescents Based on Gas Chromatography–Mass Spectrometry

Contact Info

Product

Resources

About