The effects of regular exercise on capsaicin-induced pulpal pain and pain-induced changes in passive avoidance learning and memory in rats

Raoof, Maryam; Shakoori, A; Kooshki, Razieh; Abbasnejad, Mehdi; Amanpour, Sara

doi:10.3344/kjp.2017.30.4.258

Cited by 8 publications

(7 citation statements)

References 47 publications

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“…These findings are consistent with previous studies showing that treadmill running exerts fewer preventive effects to reduce nocifensive responses in neuropathic pain models [14,69,78]. In contrast, daily exercise for several weeks before acute tooth pulp stimulation decreases orofacial nocifensive behaviors [41]. These discrepancies are likely due to the differences in pain models and treadmill running protocols, and our treadmill running protocol (10 m/min, 30 min, 10 days) was not sufficient to behaviorally decrease masseter muscle nociception in non-SDS mice.…”

Section: Discussionsupporting

confidence: 92%

“…The second aim of this study was to determine the role of physical exercise in masseter muscle nociception, as indicated by orofacial nocifensive behaviors in SDS-susceptible mice. A few studies have demonstrated that exercise decreases orofacial nociception in models of tooth pulp [41] and infraorbital nerve injury pain [42]; however, there is a lack of evidence on the effect of exercise on deep craniofacial nociception. This study employed a treadmill running paradigm because parameters such as duration and intensity could be accurately controlled.…”

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confidence: 99%

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Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice

Hasegawa

Piriyaprasath

Ôtake

et al. 2022

European J Oral Sciences

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We investigated the effects of social defeat stress (SDS) and treadmill running on masseter muscle nociception, which was quantified by the orofacial formalin test and c-Fos and FosB immunoreactivities in the upper cervical spinal cord (C1/C2) region in male mice. After daily SDS or non-SDS conditioning for 10 days, SDS-conditioned mice were categorized into SDS-susceptible versus resilient mice. Several mice, including non-SDS-conditioned, SDS-susceptible, and resilient mice, were selected to assess masseter muscle nociception on Day 11. SDS conditioning for 10 days increased masseter muscle-evoked nocifensive behaviors and c-Fos and FosB expression in SDS-susceptible compared to non-SDS and resilient mice. The remaining SDS-susceptible and non-SDS mice were subjected to an additional 10 days of SDS plus treadmill running or sedentary sessions before assessing masseter muscle nociception on Day 21. Daily treadmill running sessions reduced enhanced masseter muscle nociception in SDS-susceptible mice but not in non-SDS mice. The preventive effects of daily treadmill running immediately after each SDS conditioning for 10 days on orofacial nocifensive behaviors were assessed on Day 11. Treadmill running conducted immediately after daily SDS inhibited enhanced orofacial nocifensive behaviors. These findings indicate that repeated SDS increases masseter muscle nociception, which could be prevented by daily treadmill running exercise.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice

Hasegawa

Piriyaprasath

Ôtake

et al. 2022

European J Oral Sciences

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“…2 ). The sample size and number of animal per groups were designated according to the pilot experiments and previous studies in the field in our lab [ 13 , 14 ].…”

Section: Methodsmentioning

confidence: 99%

The role of basolateral amygdala orexin 1 receptors on the modulation of pain and psychosocial deficits in nitroglycerin-induced migraine model in adult male rats

et al. 2022

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Background: Migraine headaches have been associated with sensory hyperactivity and anomalies in social/emotional responses. The main objective of this study was to evaluate the potential involvement of orexin 1 receptors (Orx1R) within the basolateral amygdala (BLA) in the modulation of pain and psychosocial dysfunction in a nitroglycerin (NTG)-induced rat model of migraine. Methods: Adult male Wistar rats were injected with NTG (5 mg/kg, intraperitoneal) every second day over nine days to induce migraine. The experiments were done in the following six groups (6 rats per group): untreated control, NTG, NTG plus vehicle, and NTG groups that were post-treated with intra-BLA microinjection of Orx1R antagonist 20, and 40 nM). Thermal hyperalgesia was assessed using the hot plate and tail-flick tests. Moreover, the elevated plus maze (EPM) and open field (OF) tests were used to assess anxiety-like behaviors. The animals' sociability was evaluated using the three-chamber social task. The NTG-induced photophobia was assessed using a light-dark box. Results: We observed no change in NTG-induced thermal hyperalgesia following administration of 20, and 40 nM). However, SB-334867 (20 and 40 nM) aggravated the NTG-induced anxiogenic responses in both the EPM and OF tasks. The NTG-induced social impairment was overpowered by SB-334867 at all doses. Time spent in the dark chamber of light-dark box was significantly increased in rats treated with SB-334867 (20 and 40 nM/rat). Conclusions: The findings suggest a role for Orx1R within the BLA in control comorbid affective complaints with migraine in rats.

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“…The dose of drugs and the number of animal per group were determined from previous studies [ 15 17 ]. Besides, our previous study indicated that intra-Vc administration of orexin-A vehicle, distilled water, and DMSO as a vehicle of OX1Rs antagonist (SB-334867-A) had no effect on the strictness of capsaicin-induced orofacial pain.…”

Section: Methodsmentioning

confidence: 99%

Orexin-A inhibits capsaicin-induced changes in cyclooxygenase-2 and brain-derived neurotrophic factor expression in trigeminal nucleus caudalis of rats

et al. 2018

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BackgroundThe trigeminal nucleus caudalis (Vc) is a primary central site for trigeminal transmitting. Noxious stimulation of the trigeminal nociceptors alters the central synaptic releases and neural expression of some inflammatory and trophic agents. Orexin-A and the orexin 1 receptor (OX1R) are expressed in pain pathways including trigeminal pain transmission. However, the the mechanism(s) underling orexin-A effects on trigeminal pain modulation have not been fully clarified.MethodsTrigeminal pain was induced by subcutaneous injection of capsaicin in the upper lip in rats. The effect of trigeminal pain on cyclooxygenase-2 (COX-2) and brain-derived neurotrophic factor (BDNF) expression in the Vc of animals was determined by immunofluorescence. Subsequently, OX1R agonist (orexin-A) and antagonist (SB-334867-A) was administrated in the Vc to investigate the possible roles of the Vc OX1R on changes in COX-2 and BDNF levels following pain induction.ResultsThe data indicated an increase in COX-2 and decrease in BDNF immuno-reactivity in the Vc of capsaicin, and capsaicin- pretreated with SB-334867-A (80 nM), groups of rat. However, the effect of capsaicin on COX-2 and BDNF expressions was reversed by a Vc microinjection of orexin-A (100 pM).ConclusionsOverall, the present data reveals that orexin-A can attenuate capsaicin-induced trigeminal pain through the modulation of pain effects on COX-2 and BDNF expressions in the Vc of rats.

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The effects of regular exercise on capsaicin-induced pulpal pain and pain-induced changes in passive avoidance learning and memory in rats

Cited by 8 publications

References 47 publications

Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice

Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice

The role of basolateral amygdala orexin 1 receptors on the modulation of pain and psychosocial deficits in nitroglycerin-induced migraine model in adult male rats

Orexin-A inhibits capsaicin-induced changes in cyclooxygenase-2 and brain-derived neurotrophic factor expression in trigeminal nucleus caudalis of rats

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