The Effects of Regular Resistance Training on the Liver’s Inflammatory Indexes, Chemerin, Resistin, and Insulin Resistance Index in Healthy and Type 2 Diabetic Male Rats

Abstract

Background and Aim The present study aimed to investigate the effect of a 10-week resistance training on the serum levels of insulin resistance index (HOMA-IR), the serum levels of liver enzymes, chemerin, and resistin in healthy and type 2 diabetic rats. Methods & Materials In this experimental study, 40 Wistar rats with the mean±SD weight of 200±48 gr were randomly divided into 4 groups (normal control, diabetic control, diabetic resistance training, and resistance training). The training groups performed regular resistance exercises for 10 weeks by ladders. Twenty-four hours after the last training session, the blood sample of rats was collected for resistin, chemerin, insulin, and liver enzymes. The obtained data were analyzed using one-way Analysis of Variance (ANOVA), Tukey posthoc test, Analysis of Covariance (ANCOVA), and Bonferroni posthoc test at a significance level of 0.05. Ethical Considerations This study was approved by the Research Ethics Committee of Arak University of Medical Sciences, Iran (Code: IR.ARAKMU.REC.1394.329). Results Diabetes induction significantly HOMA-IR, the serum levels of liver enzymes, resistin, and chemerin in the diabetic control group, compared to the healthy control group (P< 0.05). Resistance training also significantly decreased insulin HOMA-IR, the serum levels of liver enzymes, resistin, and chemerin in the diabetic resistance training group, compared to the diabetic control group (P<0.05). Conclusion The obtained data suggested that resistance training improved liver enzymes in type 2 diabetic rats by decreasing the insulin HOMA-IR, the serum levels of chamirin, and resistin.