The effects of repetitious topical use of mitomycin C on antrostomy patency in maxillary antrostomy created rabbit model

Abstract

The aim of our study was to investigate the effect of the topical use of mitomycin C (MMC) intraoperatively in single dose and intra-postoperatively in two doses on the narrowing of antrostomy in maxillary rabbit sinus antrostomies created experimentally. And also to determine the local and systemic side effects of topical MMC. With this objective, 0.6 mg/ml MMC was used to the first group at single dose and to the second group intraoperatively and on third day postoperatively in two doses topically for 5 min. After 8 weeks, although the mean area of antrostomy was larger than that in the control side in the first group, which received single dose MMC, the difference was not statistically significant (p = 0.287). The second group received two doses, and the antrostomy areas were found to be significantly larger than the controls (p = 0.05). Overall, the sides that received MMC were significantly larger (p = 0.029). From the point of histopathological examination of the tissue, it was seen that two-dose MMC increased the edema indicating inflammation and antrostomy resolved with normal respiratory tract epithelium. It was shown by measuring the blood values that nephrotoxic and myelosupressant effect of MMC occurring in systemic use did not occur with single or double dose topical use. Our results demonstrate that even if the number of cases was low, two doses of topical MMC usage prevent the narrowing of antrostomy while single dose MMC does not. And two-dose topical MMC usage does not have local and systemic side effects.

Aktueller Stand der endonasalen Nasennebenhöhlenchirurgie

“…Empfohlen ist die Anwendung einer Lösung von 0,4-0,5 mg/ml für 5 min und die anschließende Spülung des Applikationsortes mit Kochsalzlösung [500]. Eine wiederholte Applikation soll die Wirkung verstärken: nach 3 Tagen (Kaninchen, [504]) bzw. 4 Wochen [499].…”

A novel technique for mitomycin-c application in frontal sinus surgery

“…Different techniques and materials (balloon, mitomycin-c, stent) have been used for the prevention of frontal sinus ostium stenosis. Although the local application of MMC is supported by animal and experimental studies (11,12) , its clinical value is still debatable especially for the frontal ostium (7,8) . This is because clinical studies did not present convincing results (13) .…”

A novel technique for mitomycin-c application in frontal sinus surgery

“…for the prevention of frontal sinus ostium stenosis. Although the local application of MMC is supported by animal and experimental studies (11,12) , its clinical value is still debatable especially for the frontal ostium (7,8) . This is because clinical studies did not present convincing results (13) .…”