The transfer of knowledge in science, technology, engineering, and mathematics (STEM) across countries is a common practice in academia, which is both timely and useful to achieve research collaborations. Through a qualitative research approach, using interviews and observations, five STEM Mexican professors shared their experiences and expectations in leading the research collaborations where professors and students participated. This qualitative inquiry utilized Sargent and Water’s (2004) academic research collaborations framework, which highlights the interactive phases for achieving successful collaborations. The findings revealed that: 1) institutional support through department chairs’ encouragement along with professors’ leadership to expand research collaborations in both countries are favorable and 2) more resources to fund students’ participation in international research collaborations and better climate that help students feel socially included and academically integrated to a new setting seem necessary. The article concludes with perspectives and implications for strengthening the research exchanges between the United States (U.S.) and Mexico. Among them, highlighting the positive impact that international research collaborations have for universities in both countries, the need to expand the funding for students’ mobility overseas, and the improvement of English language training to strengthen students’ connections, and, consequently, collaboration.