The Effects of Reserpine and Chlorpromazine on Gastric Secretion

Effects of Chlorpromazine and Bromolysergic Acid Diethylamide on Gastric Secretion of Acid Induced by Histamine in Rats

“…1). This effect may be analogous to the inhibition of gastric acid secretion by chlorpromazine which has been demonstrated in healthy human subjects (Haverbach, Stevenson, Sjoerdsma & Terry, 1955), in patients with duodenal ulcer (Sun & Shay, 1959a), in dogs (Sun & Shay, 1959b) and in rats (Tiede, Pfeiffer & Gass, 1963;Konturek & Radecki, 1963). The effect is probably of central origin and mediated by the vagus (Sun & Shay, 1959b).…”

Gastric Mucosal Erosion in the Rat Following Administration of the Serotonin Precursor, 5-Hydroxytryptophan

“…In the interval 2 0 to 60 minutes after admin- istration of 20 mg per kg of 5HTP these values declined to 2 ml and 0 meq per liter, respectively. Although reserpine produces gastric erosions, it is not necessary to attribute these to the demonstrated stimulation of gastric secretion in dog and man (8,9). Selye and others have demonstrated that similar erosions may be produced in the rat by a variety of drugs, traumatic injuries, burns, excessive muscular exercise, cold and other alarming stimuli ( 10).…”

Digestive System

“…Orally administered reserpine also provokes acid secretion promptly, but chlorpromazine has no such effect (69). One observer reported no change in the morning basal secre tion of gastric acid in 20 patients after taking 1 mgm.…”